Anxiolytic and Anxiogenic? How the Transcription Factor MEF2 Might Explain the Manifold Behavioral Effects of Oxytocin

Myocyte Enhancer Factor 2A (MEF2A) Defines Oxytocin-Induced Morphological Effects and Regulates Mitochondrial Function in Neurons

(2020) Magdalena Meyer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

De novo protein synthesis mediated by the eukaryotic elongation factor 2 (eEF2) is required for the anxiolytic effect of oxytocin

(2019) Stefanie Martinetz et al.   BIOLOGICAL PSYCHIATRY

SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons

(2019) Kirill Zaslavsky et al.   NATURE NEUROSCIENCE

Activation of the Oxytocin Receptor Modulates the Expression of Synaptic Adhesion Molecules in a Cell-Specific Manner

(2019) M. Zatkova et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

A Fear Memory Engram and Its Plasticity in the Hypothalamic Oxytocin System

(2019) Mazahir T. Hasan et al.   NEURON

Cortisol and oxytocin show independent activity during chimpanzee intergroup conflict

(2019) L. Samuni et al.   PSYCHONEUROENDOCRINOLOGY

Effects of chronic intranasal oxytocin on behavior and cerebral glucose uptake in juvenile titi monkeys

(2019) Rocío Arias del Razo et al.   PSYCHONEUROENDOCRINOLOGY

Oxytocin Receptors in the Anteromedial Bed Nucleus of the Stria Terminalis Promote Stress-Induced Social Avoidance in Female California Mice

(2018) Natalia Duque-Wilckens et al.   BIOLOGICAL PSYCHIATRY

Oxytocin Signaling in the Lateral Septum Prevents Social Fear during Lactation

(2018) Rohit Menon et al.   CURRENT BIOLOGY

Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A)

(2018) Magdalena Meyer et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The Oxytocin Receptor: From Intracellular Signaling to Behavior

(2018) Benjamin Jurek et al.   PHYSIOLOGICAL REVIEWS

Molecular Mechanisms of Oxytocin Signaling at the Synaptic Connection

(2018) Jan Bakos et al.   NEURAL PLASTICITY

Novel MEF2C point mutations in Chinese patients with Rett (−like) syndrome or non-syndromic intellectual disability: insights into genotype-phenotype correlation

(2018) Jiaping Wang et al.   BMC Medical Genetics

The Basolateral Amygdala Is Essential for Rapid Escape: A Human and Rodent Study

(2018) David Terburg et al.   CELL

A neuronal enhancer network upstream of MEF2C is compromised in patients with Rett-like characteristics

(2018) Eva D’haene et al.   HUMAN MOLECULAR GENETICS

The Role of CREB, SRF, and MEF2 in Activity-Dependent Neuronal Plasticity in the Visual Cortex

(2017) Nisha S. Pulimood et al.   JOURNAL OF NEUROSCIENCE

Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment

(2017) Luz Torner et al.   PSYCHONEUROENDOCRINOLOGY

NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism

(2017) Shichun Tu et al.   Nature Communications

Oxytocin enhances observational fear in mice

(2017) Marc T. Pisansky et al.   Nature Communications

Dose-dependent social-cognitive effects of intranasal oxytocin delivered with novel Breath Powered device in adults with autism spectrum disorder: a randomized placebo-controlled double-blind crossover trial

(2017) D S Quintana et al.   Translational Psychiatry

Assembling the Puzzle: Pathways of Oxytocin Signaling in the Brain

(2016) Valery Grinevich et al.   BIOLOGICAL PSYCHIATRY

The Social Salience Hypothesis of Oxytocin

(2016) Simone G. Shamay-Tsoory et al.   BIOLOGICAL PSYCHIATRY

A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors

(2016) Kun Li et al.   CELL

The Central Nervous System and the Gut Microbiome

(2016) Gil Sharon et al.   CELL

Intranasal administration of oxytocin increases human aggressive behavior

(2016) R. Ne'eman et al.   HORMONES AND BEHAVIOR

FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination

(2016) Nien-Pei Tsai et al.   HUMAN MOLECULAR GENETICS

Downregulation of Oxytocin Receptor Decreases the Length of Projections Stimulated by Retinoic Acid in the U-87MG Cells

(2016) Z. Lestanova et al.   NEUROCHEMICAL RESEARCH

Plasma Oxytocin in Children with Autism and Its Correlations with Behavioral Parameters in Children and Parents

(2016) Veronika Marcincakova Husarova et al.   Psychiatry Investigation

Local oxytocin tempers anxiety by activating GABAA receptors in the hypothalamic paraventricular nucleus

(2016) Adam S. Smith et al.   PSYCHONEUROENDOCRINOLOGY

Oxytocin selectively facilitates learning with social feedback and increases activity and functional connectivity in emotional memory and reward processing regions

(2015) Jiehui Hu et al.   HUMAN BRAIN MAPPING

Oxytocin Regulates Stress-Induced Crf Gene Transcription through CREB-Regulated Transcription Coactivator 3

(2015) B. Jurek et al.   JOURNAL OF NEUROSCIENCE

Interactions between mitochondria and the transcription factor myocyte enhancer factor 2 (MEF2) regulate neuronal structural and functional plasticity and metaplasticity

(2015) Janaina Brusco et al.   JOURNAL OF PHYSIOLOGY-LONDON

Oxytocin Stimulates Extracellular Ca2+ Influx Through TRPV2 Channels in Hypothalamic Neurons to Exert Its Anxiolytic Effects

(2015) Erwin H van den Burg et al.   NEUROPSYCHOPHARMACOLOGY

Gastrointestinal microbiota in children with autism in Slovakia

(2015) Aleksandra Tomova et al.   PHYSIOLOGY & BEHAVIOR

Identification of a Common Neurobiological Substrate for Mental Illness

(2015) Madeleine Goodkind et al.   JAMA Psychiatry

Oxytocin Modulates Female Sociosexual Behavior through a Specific Class of Prefrontal Cortical Interneurons

(2014) Miho Nakajima et al.   CELL

Brain Oxytocin in Social Fear Conditioning and Its Extinction: Involvement of the Lateral Septum

(2014) Iulia Zoicas et al.   NEUROPSYCHOPHARMACOLOGY

Plasma oxytocin concentrations and OXTR polymorphisms predict social impairments in children with and without autism spectrum disorder

(2014) K. J. Parker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice

(2014) Sebastian Peters et al.   PSYCHONEUROENDOCRINOLOGY

Myelination and Oligodendrocyte Functions in Psychiatric Diseases

(2014) Klaus-Armin Nave et al.   JAMA Psychiatry

MEF2 Is an In Vivo Immune-Metabolic Switch

(2013) Rebecca I. Clark et al.   CELL

Oxytocin administration alters HPA reactivity in the context of parent–infant interaction

(2013) Omri Weisman et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Fear-enhancing effects of septal oxytocin receptors

(2013) Yomayra F Guzmán et al.   NATURE NEUROSCIENCE

Enrichment of Conserved Synaptic Activity-Responsive Element in Neuronal Genes Predicts a Coordinated Response of MEF2, CREB and SRF

(2013) Fernanda M. Rodríguez-Tornos et al.   PLoS One

Central CRF neurons are not created equal: phenotypic differences in CRF-containing neurons of the rat paraventricular hypothalamus and the bed nucleus of the stria terminalis

(2013) Joanna Dabrowska et al.   Frontiers in Neuroscience

RGS2 mediates the anxiolytic effect of oxytocin

(2012) Naoki Okimoto et al.   BRAIN RESEARCH

The Transcription Factor MEF2 Directs Developmental Visually Driven Functional and Structural Metaplasticity

(2012) Simon Xuan Chen et al.   CELL

Oxytocin increases anxiety to unpredictable threat

(2012) C Grillon et al.   MOLECULAR PSYCHIATRY

MEF2 negatively regulates learning-induced structural plasticity and memory formation

(2012) Christina J Cole et al.   NATURE NEUROSCIENCE

Evoked Axonal Oxytocin Release in the Central Amygdala Attenuates Fear Response

(2012) H. Sophie Knobloch et al.   NEURON

In Vivo Analysis of MEF2 Transcription Factors in Synapse Regulation and Neuronal Survival

(2012) M. Waseem Akhtar et al.   PLoS One

Differential Contribution of Hypothalamic MAPK Activity to Anxiety-Like Behaviour in Virgin and Lactating Rats

(2012) Benjamin Jurek et al.   PLoS One

Central administration of oxytocin receptor ligands affects cued fear extinction in rats and mice in a timepoint-dependent manner

(2012) Iulia Toth et al.   PSYCHOPHARMACOLOGY

Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors

(2012) Inga D. Neumann et al.   TRENDS IN NEUROSCIENCES

Differences in white matter reflect atypical developmental trajectory in autism: A Tract-based Spatial Statistics study

(2012) Reyhaneh Bakhtiari et al.   NeuroImage-Clinical

Direct regulation of complex I by mitochondrial MEF2D is disrupted in a mouse model of Parkinson disease and in human patients

(2011) Hua She et al.   JOURNAL OF CLINICAL INVESTIGATION

Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine

(2011) Andreas Meyer-Lindenberg et al.   NATURE REVIEWS NEUROSCIENCE

Yes, I Am Ready Now: Differential Effects of Paced versus Unpaced Mating on Anxiety and Central Oxytocin Release in Female Rats

(2011) Kewir D. Nyuyki et al.   PLoS One

Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala

(2011) D. Viviani et al.   SCIENCE

Neuroendocrine and cardiovascular parameters during simulation of stress-induced rise in circulating oxytocin in the rat

(2010) M. Ondrejcakova et al.   STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS

Intranasal Administration of Oxytocin Increases Envy and Schadenfreude (Gloating)

(2009) Simone G. Shamay-Tsoory et al.   BIOLOGICAL PSYCHIATRY

Autistic Phenotype from MEF2C Knockout Cells

(2009) S. A. Lipton et al.   SCIENCE

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

(2008) Steven W. Flavell et al.   Annual Review of Neuroscience

Oxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus

(2008) Annegret Blume et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

TRPC6 channels promote dendritic growth via the CaMKIV-CREB pathway

(2008) Y. Tai et al.   JOURNAL OF CELL SCIENCE

Brain Oxytocin: A Key Regulator of Emotional and Social Behaviours in Both Females and Males

(2008) I. D. Neumann   JOURNAL OF NEUROENDOCRINOLOGY

Oxytocin enhances processing of positive versus negative emotional information in healthy male volunteers

(2008) M Di Simplicio et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Critical role of TRPC6 channels in the formation of excitatory synapses

(2008) Jian Zhou et al.   NATURE NEUROSCIENCE

Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection

(2008) Steven W. Flavell et al.   NEURON

Identifying Autism Loci and Genes by Tracing Recent Shared Ancestry

(2008) E. M. Morrow et al.   SCIENCE