Review
Biochemistry & Molecular Biology
Cristina Herrera-Pariente, Sheyla Montori, Joan Llach, Alex Bofill, Eduardo Albeniz, Leticia Moreira
Summary: Gastric cancer is a common cancer worldwide, with early detection being crucial for improving clinical outcomes. Current screening programs are effective in high-incidence populations but not cost-effective in low-incidence populations, highlighting the need for new noninvasive biomarkers.
Review
Oncology
Shiyu Li, Ming Yi, Bing Dong, Ximin Tan, Suxia Luo, Kongming Wu
Summary: Exosomes, as a new type of liquid biopsy, have the potential to be diagnostic or prognostic biomarkers by delivering cargos including nucleic acids and protein, involving in tumorigenesis, tumor growth, metastasis, and drug resistance.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemical Research Methods
Hua-Ping Liu, Hung-Ming Lai, Zheng Guo
Summary: This study investigated the potential of circulating miRNA pairs for improving early diagnosis of prostate cancer, revealing that a model based on class separability miRNA pairs (cs-miRPs) achieved approximately 99% diagnostic performance in key indicators. The findings suggest that utilizing circulating miRNA pairs could offer significant benefits for the early diagnosis of prostate cancer in clinical practice.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Immunology
Camila Espejo, Richard Wilson, Ruth J. Pye, Julian C. Ratcliffe, Manuel Ruiz-Aravena, Eduard Willms, Barrett W. Wolfe, Rodrigo Hamede, Andrew F. Hill, Menna E. Jones, Gregory M. Woods, A. Bruce Lyons
Summary: The identification of practical early diagnostic biomarkers is crucial for improving cancer prevention and treatment. Researchers have analyzed the extracellular vesicle (EV) proteome in Tasmanian devil serum samples and found that the antimicrobial peptide cathelicidin-3 (CATH3) is enriched in both devils with clinical devil facial tumor disease (DFTD) and devils with latent infection. This finding suggests that antimicrobial peptides can serve as accurate cancer biomarkers and has implications for conservation strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Irene Tatischeff
Summary: Each human cancer is unique, but early diagnosis is critical for optimal patient outcomes. Liquid biopsy in blood, as a non-invasive alternative to tissue biopsies, has brought significant advancements to cancer diagnosis. Research has focused on circulating tumor cells, cell-free tumor DNA, and more recently, extracellular vesicles (EVs) as potential cancer biomarkers. This review discusses the exploration of EV-DNA as a promising biomarker, the challenges involved, and the need for further research before its clinical application.
Article
Chemistry, Multidisciplinary
Chang-Chieh Hsu, Yunchen Yang, Eric Kannisto, Xie Zeng, Guan Yu, Santosh K. Patnaik, Grace K. Dy, Mary E. Reid, Qiaoqiang Gan, Yun Wu
Summary: Tumor-derived exosomes (TEXs) are considered as promising biomarkers for cancer liquid biopsy. We developed an ExoPROS biosensor that selectively captures TEXs and enables simultaneous detection of TEX protein-microRNA pairs using a surface plasmon resonance mechanism. The assay demonstrated high accuracy for lung cancer and breast cancer diagnosis compared to conventional methods. The ExoPROS assay is a potent liquid biopsy assay for cancer diagnosis.
Review
Biochemistry & Molecular Biology
Alexey S. S. Rzhevskiy, Alina Y. Y. Kapitannikova, Denis V. V. Butnaru, Evgeniy V. V. Shpot, Simon A. A. Joosse, Andrei V. V. Zvyagin, Majid Ebrahimi Warkiani
Summary: Currently, there is a lack of sensitive and specific methods for the detection and prognosis of early stage prostate cancer. Liquid biopsy, a novel technique that extracts biomarkers such as circulating tumor cells, exosomal miRNAs, and circulating DNAs, has been investigated as a supplement or alternative to the traditional screening methods for prostate cancer.
Review
Oncology
Claudia Freitas, Catarina Sousa, Francisco Machado, Mariana Serino, Vanessa Santos, Natalia Cruz-Martins, Armando Teixeira, Antonio Cunha, Tania Pereira, Helder P. Oliveira, Jose Luis Costa, Venceslau Hespanhol
Summary: Liquid biopsy is an emerging technology that shows potential in the screening and early detection of lung cancer. Various liquid biopsy-derived biomarkers have been identified, but their diagnostic performance and clinical applicability are still limited. Combining different biomarkers and using them in conjunction with other diagnostic tools hold promise, but further research is needed to define and validate the role of liquid biopsies in clinical practice.
FRONTIERS IN ONCOLOGY
(2021)
Review
Pathology
Alireza Azani, Sima Parvizi Omran, Haniyeh Ghasrsaz, Asra Idani, Mahdis kadkhodaei Eliaderani, Niloufar Peirovi, Negar Dokhani, Mohamad hassan Lotfalizadeh, Mohammadhadi mohammadzadeh Rezaei, Mehrnoosh shahgholian Ghahfarokhi, Sepideh Karkonshayan, Parisa najari Hanjani, Zahra Kardaan, Jamshid Gholizadeh Navashenagh, Meysam Yousefi, Mitra Abdolahi, Arash Salmaninejad
Summary: Prostate cancer is a leading cause of cancer-related deaths in men worldwide, due to late detection. Current diagnostic methods have low accuracy, so there is a need for new biomarkers. Recent studies suggest that microRNAs play a role in the initiation and progression of prostate cancer and can be used as biomarkers for diagnosis, prognosis, and disease relapse.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Xiao Zhou, Zhen Cheng, Mingyu Dong, Qi Liu, Weiyang Yang, Min Liu, Junzhang Tian, Weibin Cheng
Summary: A diagnostic model using tumor fractions deciphered from circulating cfDNA methylation signatures has been developed for early-stage cancer detection, exhibiting an 86% sensitivity. The approach demonstrates the potential of tumor fractions in cancer early diagnosis, which can be further utilized for cancer screening and tumor progression monitoring.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Henry Ademola Adeola, Ibrahim O. Bello, Raphael Taiwo Aruleba, Ngiambudulu M. Francisco, Tayo Alex Adekiya, Anthonio Oladele Adefuye, Paul Chukwudi Ikwegbue, Fungai Musaigwa
Summary: Liquid biopsy is an attractive option for mouth cancer detection that is non-invasive and can use easily accessible body fluids. This article discusses the practicality of using liquid biopsy in Africa and other low-income countries, as well as the different types of liquid biopsy and factors related to sample collection, analysis, and statistical quality.
Review
Gastroenterology & Hepatology
Tasuku Matsuoka, Masakazu Yashiro
Summary: Gastric cancer is a major cause of cancer-related death worldwide, with a lack of early symptoms leading to late-stage diagnosis in less than half of the cases. The disease is heterogeneous and associated with genetic and somatic mutations. Noninvasive tests detecting gastric cancer alterations, such as blood-based biomarkers, show promise in improving early detection and monitoring of tumor progression. This review provides an overview of the current research on novel diagnostic markers for gastric cancer.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Cell Biology
Jing Ning, Tao Ge, Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He
Summary: The research focuses on various early diagnosis methods for lung cancer, aiming to improve early diagnosis rates and explore feasible and effective strategies. This includes imaging screening, bronchoscopy, and emerging potential liquid biopsies, as well as volatile organic compounds and autoantibodies.
Article
Chemistry, Multidisciplinary
Yangcenzi Xie, Xiaoming Su, Yu Wen, Chao Zheng, Ming Li
Summary: This study reports an artificial intelligent surface-enhanced Raman spectroscopy (SERS) strategy for accurate diagnosis and assessment of breast cancer. The deep learning algorithm trained with SERS spectra achieved a 100% prediction accuracy for different breast cancer subtypes, and when combined with similarity analysis, it can evaluate the surgical outcomes.
Review
Biochemistry & Molecular Biology
Roberta Belli, Elisabetta Ferraro, Alessio Molfino, Raffaella Carletti, Federica Tambaro, Paola Costelli, Maurizio Muscaritoli
Summary: Cancer cachexia, characterized by unintentional weight loss due to systemic inflammation, impaired energy metabolism, and loss of muscle and adipose tissues, poses challenges in early diagnosis due to the lack of biomarkers. Liquid biopsy and circulating miRNAs have emerged as potential sources of easily accessible biomarkers for early detection, especially in the context of muscle atrophy related to cancer cachexia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Xiaoyi Huang, Tiezheng Yuan, Meihua Liang, Meijun Du, Shu Xia, Rachel Dittmar, Dian Wang, William See, Brian A. Costello, Fernando Quevedo, Winston Tan, Debashis Nandy, Graham H. Bevan, Sherri Longenbach, Zhifu Sun, Yan Lu, Tao Wang, Stephen N. Thibodeau, Lisa Boardman, Manish Kohli, Liang Wang
Review
Oncology
Ci Zhao, Guanyu Wang, Yuanyuan Zhu, Xiaobo Li, Feihu Yan, Chunhui Zhang, Xiaoyi Huang, Yanqiao Zhang
Article
Oncology
Meihua Liang, Fei Zhan, Juan Zhao, Qi Li, Jiazi Wuyang, Guannan Mu, Dianjun Li, Yanqiao Zhang, Xiaoyi Huang
Article
Peripheral Vascular Disease
Kai-jing Yu, Ji-rong Zhang, Ying Li, Xiaoyi Huang, Tiemin Liu, Chuanfu Li, Rui-tao Wang
HYPERTENSION RESEARCH
(2017)
Article
Immunology
Yuanlong Gu, Huimin Lv, Juan Zhao, Qi Li, Guannan Mu, Jiade Li, Jiazi Wuyang, Ge Lou, Ruitao Wang, Yanqiao Zhang, Xiaoyi Huang
INTERNATIONAL IMMUNOPHARMACOLOGY
(2017)
Article
Multidisciplinary Sciences
Na Li, Zhiyong Diao, Xiaoyi Huang, Ye Niu, Tiemin Liu, Zhi-ping Liu, Rui-tao Wang, Kai-jiang Yu
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Meijun Du, Tiezheng Yuan, Kala F. Schilter, Rachel L. Dittmar, Alexander Mackinnon, Xiaoyi Huang, Michael Tschannen, Elizabeth Worthey, Howard Jacob, Shu Xia, Jianzhong Gao, Lori Tilmans, Yan Lu, Pengyuan Liu, Stephen N. Thibodeau, Liang Wang
HUMAN MOLECULAR GENETICS
(2015)
Article
Multidisciplinary Sciences
Tiezheng Yuan, Xiaoyi Huang, Mark Woodcock, Meijun Du, Rachel Dittmar, Yuan Wang, Susan Tsai, Manish Kohli, Lisa Boardman, Tushar Patel, Liang Wang
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Ci Zhao, Qi Zhao, Chunhui Zhang, Guangyu Wang, Yuanfei Yao, Xiaoyi Huang, Fei Zhan, Yuanyuan Zhu, Jiaqi Shi, Jianan Chen, Feihu Yan, Yanqiao Zhang
SCIENTIFIC REPORTS
(2017)
Article
Multidisciplinary Sciences
Jing Wang, Feihu Yan, Qi Zhao, Fei Zhan, Ruitao Wang, Liang Wang, Yanqiao Zhang, Xiaoyi Huang
SCIENTIFIC REPORTS
(2017)
Review
Oncology
Fei Zhan, Jingling Shen, Ruitao Wang, Liang Wang, Yao Dai, Yanqiao Zhang, Xiaoyi Huang
CANCER MANAGEMENT AND RESEARCH
(2018)
Article
Gastroenterology & Hepatology
Li Li, Xiao-Yi Huang, Na Li, Ming-ming Cui, Rui-tao Wang
GASTROENTEROLOGY RESEARCH AND PRACTICE
(2019)
Article
Genetics & Heredity
Meihua Liang, Siming Yu, Shuli Tang, Lu Bai, Jianan Cheng, Yuanlong Gu, Shuang Li, Xin Zheng, Lian Duan, Liang Wang, Yanqiao Zhang, Xiaoyi Huang
FRONTIERS IN GENETICS
(2020)
Review
Biotechnology & Applied Microbiology
Shuli Tang, Siming Yu, Jianan Cheng, Yanqiao Zhang, Xiaoyi Huang
INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
(2020)