Article
Plant Sciences
Lei Wang, Jinqing Xu, Handong Wang, Tongrui Chen, En You, Haiyan Bian, Wenjie Chen, Bo Zhang, Yuhu Shen
Summary: A collection of 288 oat lines from around the world were evaluated to study the genetic diversity, population structure, and linkage disequilibrium of oat. The results showed high genetic diversity and strong population structure in the oat lines. Significant associations were found between markers and traits related to hullessness and lemma color. These findings have important implications for further research and breeding of oat in high-altitude regions.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Genetics & Heredity
Douglas P. Wightman, Iris E. Jansen, Jeanne E. Savage, Alexey A. Shadrin, Shahram Bahrami, Dominic Holland, Arvid Rongve, Sigrid Borte, Bendik S. Winsvold, Ole Kristian Drange, Amy E. Martinsen, Anne Heidi Skogholt, Cristen Willer, Geir Brathen, Ingunn Bosnes, Jonas Bille Nielsen, Lars G. Fritsche, Laurent F. Thomas, Linda M. Pedersen, Maiken E. Gabrielsen, Marianne Bakke Johnsen, Tore Wergeland Meisingset, Wei Zhou, Petroula Proitsi, Angela Hodges, Richard Dobson, Latha Velayudhan, Julia M. Sealock, Lea K. Davis, Nancy L. Pedersen, Chandra A. Reynolds, Ida K. Karlsson, Sigurdur Magnusson, Hreinn Stefansson, Steinunn Thordardottir, Palmi Jonsson, Jon Snaedal, Anna Zettergren, Ingmar Skoog, Silke Kern, Margda Waern, Henrik Zetterberg, Kaj Blennow, Eystein Stordal, Kristian Hveem, John-Anker Zwart, Lavinia Athanasiu, Per Selnes, Ingvild Saltvedt, Sigrid B. Sando, Ingun Ulstein, Srdjan Djurovic, Tormod Fladby, Dag Aarsland, Geir Selbaek, Stephan Ripke, Kari Stefansson, Ole A. Andreassen, Danielle Posthuma
Summary: This study identified seven new genetic loci associated with Alzheimer's disease through a genome-wide association study, implicating microglia and immune cells in late-onset disease. The research highlights the relevance of microglia, immune cells, and protein catabolism to late-onset Alzheimer's disease, while prioritizing previously unidentified genes for further investigation. The results are expected to contribute to larger meta-analyses to uncover additional genetic variants affecting Alzheimer's pathology.
Article
Multidisciplinary Sciences
Waheed-Ul-Rahman Ahmed, Sam Kleeman, Michael Ng, Wei Wang, Adam Auton, Regent Lee, Ashok Handa, Krina T. Zondervan, Akira Wiberg, Dominic Furniss
Summary: This study describes the largest genome-wide association study of varicose veins, identifying 46 susceptibility loci and 49 signals. The study also maps 237 genes to these loci, providing potential targets for therapeutic interventions. Pathway analysis reveals several biological processes related to varicose veins.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Samar M. Esmail, Diego Jarquin, Andreas Boerner, Ahmed Sallam
Summary: This study evaluated the NB and PM resistance of 122 diverse barley genotypes from 34 countries and found high genetic variation among the genotypes. No significant correlation was found between PM and NB resistance, but 21 genotypes immune to both diseases were identified. Furthermore, GWAS identified SNP markers associated with increased resistance to PM and NB.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Cell Biology
Yingjie Guo, Chenxi Wu, Zhian Yuan, Yansu Wang, Zhen Liang, Yang Wang, Yi Zhang, Lei Xu
Summary: This article introduces a gene-based method to detect gene-gene interactions by adding additive constraints to the model, and experimental results show that this method outperforms previous experiments in detecting gene-gene interactions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Nathan A. Kimbrel, Allison E. Ashley-Koch, Xue J. Qin, Jennifer H. Lindquist, Melanie E. Garrett, Michelle F. Dennis, Lauren P. Hair, Jennifer E. Huffman, Daniel A. Jacobson, Ravi K. Madduri, Jodie A. Trafton, Hilary Coon, Anna R. Docherty, Jooeun Kang, Niamh Mullins, Douglas M. Ruderfer, Philip D. Harvey, Benjamin H. McMahon, David W. Oslin, Elizabeth R. Hauser, Michael A. Hauser, Jean C. Beckham
Summary: This study identified pan-ancestry and ancestry-specific loci associated with suicide attempts among veterans, highlighting the complex genetic architecture underlying suicide risk. Pathway analyses suggested several biological pathways with clinical significance that could be targeted for the development of improved therapeutics for suicide prevention.
MOLECULAR PSYCHIATRY
(2022)
Article
Biotechnology & Applied Microbiology
Long-Bin Zhang, Wu-Wei-Jie Yang, Ting-Ting Qiu
Summary: This study conducted a comprehensive genome-wide analysis of the laccase gene family in C. unicolor 87613, identifying 18 CuLacs genes and characterizing their properties. The study also investigated the transcription patterns and 3D structures of CuLac proteins, revealing the influence of specific structures on substrate affinity.
Article
Genetics & Heredity
Michal Marczyk, Agnieszka Macioszek, Joanna Tobiasz, Joanna Polanska, Joanna Zyla
Summary: The study evaluated the impact of different integration methods and linkage disequilibrium correction on multiple GSA algorithms, with CERNO and MAGENTA combined with Stouffer method showing the most efficiency. LD correction increased prioritization and specificity of enrichment outcomes for all tested algorithms. The best performance was observed when using Fisher or Stouffer integration with LD correction.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Yin Huang, Dan Li, Lu Qiao, Yu Liu, Qianqian Peng, Sijie Wu, Manfei Zhang, Yajun Yang, Jingze Tan, Shuhua Xu, Li Jin, Sijia Wang, Kun Tang, Stefan Grunewald
Summary: This study conducted a genome-wide association study on the genetic basis of facial morphology in the Han Chinese population, identifying significant associations between multiple facial features and different genomic regions. These findings contribute to a more comprehensive understanding of the genetic factors underlying variation in human facial morphology.
JOURNAL OF GENETICS AND GENOMICS
(2021)
Article
Endocrinology & Metabolism
Yang Liu, Yun Wang, Shan Qin, Xinye Jin, Lingzi Jin, Weijun Gu, Yiming Mu
Summary: This article evaluated the hotspots and future trends in GWAS research in diabetes through bibliometric analysis. The findings showed an increasing trend in the annual number of publications and citations in GWAS in diabetes over the past two decades. Harvard University and Harvard Medical School have played significant roles in genome research. The study predicted that DNA methylation and genetic variation, especially in type 2 diabetes, are likely to remain the research hotspots.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Genetics & Heredity
Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich, Marilyn C. Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S. Ahluwalia, Traci M. Bartz, Amy R. Bentley, Lawrence F. Bielak, Mike Chong, Audrey Y. Chu, Diane Berry, Rajkumar Dorajoo, Nicole D. Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F. Feitosa, Christian Gieger, Mariaelisa Graff, Leanne M. Hall, Toomas Haller, Fernando P. Hartwig, David A. Hillis, Ville Huikari, Nancy Heard-Costa, Christina Holzapfel, Anne U. Jackson, Asa Johansson, Anja Moltke Jorgensen, Marika A. Kaakinen, Robert Karlsson, Kathleen F. Kerr, Boram Kim, Chantal M. Koolhaas, Zoltan Kutalik, Vasiliki Lagou, Penelope A. Lind, Mattias Lorentzon, Leo-Pekka Lyytikainen, Massimo Mangino, Christoph Metzendorf, Kristine R. Monroe, Alexander Pacolet, Louis Perusse, Rene Pool, Rebecca C. Richmond, Natalia Rivera, Sebastien Robiou-Du-Pont, Katharina E. Schraut, Christina-Alexandra Schulz, Heather M. Stringham, Toshiko Tanaka, Alexander Teumer, Constance Turman, Peter J. Van der Most, Mathias Vanmunster, Frank J. A. Van Rooij, Jana V. Van Vliet-Ostaptchouk, Xiaoshuai Zhang, Jing-Hua Zhao, Wei Zhao, Zhanna Balkhiyarova, Marie N. Balslev-Harder, Sebastian E. Baumeister, John Beilby, John Blangero, Dorret Boomsma, Soren Brage, Peter S. Braund, Jennifer A. Brody, Marcel Bruinenberg, Ulf Ekelund, Ching-Ti Liu, John W. Cole, Francis S. Collins, L. Adrienne Cupples, Tonu Esko, Stefan Enroth, Jessica D. Faul, Lindsay Fernandez-Rhodes, Alison E. Fohner, Oscar H. Franco, Tessel E. Galesloot, Scott D. Gordon, Niels Grarup, Catharina A. Hartman, Gerardo Heiss, Jennie Hui, Thomas Illig, Russell Jago, Alan James, Peter K. Joshi, Taeyeong Jung, Mika Kahonen, Tuomas O. Kilpelainen, Woon-Puay Koh, Ivana Kolcic, Peter P. Kraft, Johanna Kuusisto, Lenore J. Launer, Aihua Li, Allan Linneberg, Jian'An Luan, Pedro Marques Vidal, Sarah E. Medland, Yuri Milaneschi, Arden Moscati, Bill Musk, Christopher P. Nelson, Ilja M. Nolte, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Christine Power, Olli T. Raitakari, Magi Reedik, Alex P. Reiner, Paul M. Ridker, Igor Rudan, Kathy Ryan, Mark A. Sarzynski, Laura J. Scott, Robert A. Scott, Stephen Sidney, Kristin Siggeirsdottir, Albert Smith, Jennifer A. Smith, Emily Sonestedt, Marin Strom, E. Shyong Tai, Koon K. Teo, Barbara Thorand, Anke Toenjes, Angelo Tremblay, Andre G. Uitterlinden, Jagadish Vangipurapu, Natasja Van Schoor, Uwe Volker, Gonneke Willemsen, Kayleen Williams, Quenna Wong, Huichun Xu, Kristin L. Young, Jian Min Yuan, M. Carola Zillikens, Alan B. Zonderman, Adam Ameur, Stefania Bandinelli, Joshua C. Bis, Michael Boehnke, Claude Bouchard, Daniel Chasman, George Davey Smith, Eco J. C. De Geus, Louise Deldicque, Marcus Dorr, Michele K. Evans, Luigi Ferrucci, Myriam Fornage, Caroline Fox, Theodore Garland, Vilmundur Gudnason, Ulf Gyllensten, Torben Hansen, Caroline Hayward, Bernardo L. Horta, Elina Hypponen, Marjo-Riitta Jarvelin, W. Craig Johnson, Sharon L. R. Kardia, Lambertus A. Kiemeney, Markku Laakso, Claudia Langenberg, Terho Lehtimaki, Loic Le Marchand, Patrik K. E. Magnusson, Nicholas G. Martin, Mads Melbye, Andres Metspalu, David Meyre, Kari E. North, Claes Ohlsson, Albertine J. Oldehinkel, Marju Orho-Melander, Guillaume Pare, Taesung Park, Oluf Pedersen, Brenda W. J. H. Penninx, Tune H. Pers, Ozren Polasek, Inga Prokopenko, Charles N. Rotimi, Nilesh J. Samani, Xueling Sim, Harold Snieder, Thorkild I. A. Sorensen, Tim D. Spector, Nicholas J. Timpson, Rob M. Van Dam, Nathalie Van der Velde, Cornelia M. Van Duijn, Peter Vollenweider, Henry Volzke, Trudy Voortman, Gerard Waeber, Nicholas J. Wareham, David R. Weir, Heinz-Erich Wichmann, James F. Wilson, Andrea L. Hevener, Anna Krook, Juleen R. Zierath, Martine A. Thomis, Ruth J. F. Loos, Marcel Den Hoed
Summary: Physical activity and sedentary behavior have genetic components, and this study identified 99 genetic loci associated with self-reported physical activity, leisure screen time, and sedentary behavior. Some genetic variants were found to affect muscle function and possibly protect against exercise-induced muscle damage. Mendelian randomization analyses also revealed that the beneficial effects of reducing sedentary behavior and increasing physical activity on health outcomes may be mediated or confounded by body mass index.
Article
Psychiatry
Nora Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, Rene Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Ruck, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret Boomsma, David Mataix-Cols, Danielle Cath
Summary: This study reveals the heritability of hoarding symptoms and identifies genetic associations with schizophrenia, autism spectrum disorder, and educational attainment. However, no significant loci were detected in the genome-wide analysis.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Venkata Rami Reddy Yannam, Marlon Caicedo, Rosa Ana Malvar, Bernardo Ordas
Summary: The study used GWAS and genome-wide association analysis to elucidate the genetic characteristics of senescence and its impact on agronomic traits. Core senescence genes could serve as crucial candidates for future gene editing and breeding purposes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Mark Simcoe, Ana Valdes, Fan Liu, Nicholas A. Furlotte, David M. Evans, Gibran Hemani, Susan M. Ring, George Davey Smith, David L. Duffy, Gu Zhu, Scott D. Gordon, Sarah E. Medland, Dragana Vuckovic, Giorgia Girotto, Cinzia Sala, Eulalia Catamo, Maria Pina Concas, Marco Brumat, Paolo Gasparini, Daniela Toniolo, Massimiliano Cocca, Antonietta Robino, Seyhan Yazar, Alex Hewitt, Wenting Wu, Peter Kraft, Christopher J. Hammond, Yuan Shi, Yan Chen, Changqing Zeng, Caroline C. W. Klaver, Andre G. Uitterlinden, M. Arfan Ikram, Merel A. Hamer, Cornelia M. van Duijn, Tamar Nijsten, Jiali Han, David A. Mackey, Nicholas G. Martin, Ching-Yu Cheng, David A. Hinds, Timothy D. Spector, Manfred Kayser, Pirro G. Hysi
Summary: This study, the largest genome-wide association study for eye color to date, identified 124 independent associations from 61 genomic regions. In addition to genes related to melanin pigmentation, genes related to iris morphology and structure were also found. The genetic complexity of human eye color was shown to exceed previous knowledge and expectations.
Article
Agronomy
Palvi Malik, Mao Huang, Kumari Neelam, Dharminder Bhatia, Ramanjeet Kaur, Bharat Yadav, Jasdeep Singh, Clay Sneller, Kuldeep Singh
Summary: Through genome-wide association study, genetic variations associated with agronomic traits were identified in Asian cultivated rice, along with potential candidate varieties. Analysis of the newly identified SNPs also revealed the absence of superior alleles, indicating the potential for introducing these genes to broaden the genetic base of cultivated rice.