Article
Cardiac & Cardiovascular Systems
Daniel J. Friedman, Dominique Pierre, Yongfei Wang, Louise Gambone, Christina Koutras, Claire Segawa, Andrew Farb, Sreekanth Vemulapalli, Paul D. Varosy, Frederick A. Masoudi, Alexandra Lansky, Jeptha P. Curtis, James V. Freeman
Summary: In this study, researchers developed a novel automated adjudication algorithm for end point adjudication in clinical trials. The algorithm showed good agreement with clinical events committee evaluation, reducing the need for formal adjudication while maintaining accuracy.
AMERICAN HEART JOURNAL
(2022)
Article
Engineering, Manufacturing
Yingjie Zhang, Liling Ge
Summary: This paper proposed a new device for geometry errors measurement and coaxiality evaluation, along with a corresponding methodology. The method allows for characterizing multiple holes at the same time, achieving measurement accuracy through the rotation of a laser sensor and other techniques.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART B-JOURNAL OF ENGINEERING MANUFACTURE
(2021)
Article
Optics
Hengyu Wang, Bin Lin, Peng Zhou, Jialong Lai
Summary: This study proposes a novel end-to-end pattern optimization technology that generates standard sinusoidal patterns on a camera image instead of a projection image, effectively avoiding nonlinear errors in phase-measuring profilometry systems and achieving high-quality three-dimensional measurement.
Article
Medicine, General & Internal
Alexandru Tudor Steriade, Mihai Gologanu, Roxana Silvia Bumbacea, Stefan Nicolae Bogdan, Dragos Bumbacea
Summary: Esophageal pressure (Pes) measurements can optimize ventilator parameters in patients with acute respiratory failure. This study evaluated the safety and accuracy of a Pes measuring protocol in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) receiving noninvasive ventilation (NIV). It was found that under NIV, the reduction of increment Pes is most significant within the first 24 hours of admission.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Quantum Science & Technology
Ilaria Gianani, Alessio Belenchia, Stefano Gherardini, Vincenzo Berardi, Marco Barbieri, Mauro Paternostro
Summary: Quantum coherence, a fundamental concept in quantum physics, has significant theoretical and technological implications. This study investigates how the coherence generated by a quantum gate is affected by unitary errors in the form of rotation-angle and rotation-axis errors. Numerical evidence supports that the statistics of local energy measurements on the output states of the gate effectively capture this information. Experimental data from a quantum optics setting further corroborate these findings.
QUANTUM SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Electrical & Electronic
Jiadong Lu, Yihua Hu, Jinglin Liu, Jie Wang, Peng Li
Summary: A fixed-point sampling method is proposed to estimate current sampling errors, which relies on the relations between measured currents rather than complex algorithms, effectively eliminating torque and speed fluctuations while reducing computational burden on the drive. Experiment results on a 1.5-kW IPMSM prototype verify the accuracy and effectiveness of this method in actual digital controllers.
IEEE TRANSACTIONS ON POWER ELECTRONICS
(2021)
Article
Chemistry, Analytical
Albert Alvarez-Carulla, Yaiza Montes-Cebrian, Jordi Colomer-Farrarons, Pere Lluis Miribel-Catala
Summary: A novel self-powered, point-of-care, low-power electronic method for sample concentration measurement using galvanic cell, provides digital user-readable result without external devices, validated with NaCl solution as electrolyte, and exhibits a maximum coefficient of variation of 6.1%.
Article
Public, Environmental & Occupational Health
Nishma P. Vias, Caitlin A. Cassidy, Jessie K. Edwards, Khou Xiong, Cherese Beatty Parker, Allison E. Aiello, Ross M. Boyce, Bonnie E. Shook-Sa
Summary: This study presents a method for adjusting seroprevalence estimates for the sensitivity and specificity of diagnostic tests in complex sample designs. The method is applied to a longitudinal seroprevalence study conducted in Chatham County, North Carolina, and provides estimates of SARS-CoV-2 seroprevalence over time.
Article
Engineering, Environmental
Zhaoyang Su, Ting Liu, Yujie Men, Shuo Li, Nigel Graham, Wenzheng Yu
Summary: This study aimed to evaluate the influence of pipe age on point-of-use water quality. The results showed that bacterial diversity is affected by pipe age, while bacterial community structure is influenced by the source water. Aging pipes in buildings were also found to contribute to the deterioration of water quality. The study identified the relationships between physico-chemical parameters and bacteria abundance, and developed an image analysis method for predicting pipe age, organic matter concentration, and hardness.
Article
Automation & Control Systems
Fei Liu, Lin Liang, Guanghua Xu, Chenggang Hou, Dan Liu
Summary: The article proposes a method for measuring rotation error, including extracting and quantifying rotation error from center orbit, and designing a systematic measurement strategy. The method is able to separate rotation error and roundness error, reduce sensor noise level, improve measurement accuracy, and consider the impact of high temperatures on form errors.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2021)
Article
Engineering, Chemical
Sha Gao, Shu Gan, Xiping Yuan, Rui Bi, Raobo Li, Lin Hu, Weidong Luo
Summary: This study validated the use of low-altitude unmanned aerial vehicle photogrammetry combined with structure-from-motion algorithms for 3D positioning accuracy. Through experimentation and analysis, it was concluded that the technology can achieve centimeter-level planimetric and vertical accuracy, providing a valuable quantitative reference for geomorphological data acquisition and 3D reconstruction.
Article
Cardiac & Cardiovascular Systems
Sara Souto-Miranda, Anouk W. Vaes, Rainer Gloeckl, Anita Grongstad, Martijn A. Spruit, Alda Marques
Summary: This study provides important insights into outcome measurement in pulmonary rehabilitation from the perspectives of key international stakeholders and identifies a set of crucial outcomes that will inform future consensus studies.
RESPIRATORY MEDICINE
(2022)
Article
Computer Science, Interdisciplinary Applications
Linda Nab, Maarten van Smeden, Ruth H. Keogh, Rolf H. H. Groenwold
Summary: Measurement error in regression models is common and can lead to bias in estimated associations. Methods for measurement error correction are available but underutilized, with the need for improved application and development of these methods to enhance estimation accuracy.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Engineering, Civil
Numa Bertola, Ze Zhou Wang, Wen-jun Cao, Ian F. C. Smith
Summary: Information collected through sensor measurements has the potential to improve knowledge of complex-system behavior, leading to better decisions related to system management. This study presents a methodology for selecting informative measurements within large data sets for a given model-updating task, which significantly refines data sets and improves data-interpretation efficiency.
JOURNAL OF CIVIL STRUCTURAL HEALTH MONITORING
(2023)
Article
Psychiatry
Grace Nduku Wambua, Manasi Kumar, Fredrik Falkenstrom, Pim Cuijpers
Summary: This study evaluated the psychometric properties of the HoNOSCA for routine use in child and adolescent mental health services in Kenya. The self-rated version of the HoNOSCA showed good reliability and correlation with the PSC, indicating sensitivity to change. Further investigation with a larger sample is recommended based on the positive findings.
Article
Cardiac & Cardiovascular Systems
Ladina Erhart, Beat A. Kaufmann, Baris Gencer, Philipp K. Haager, Hajo Mulller, Richard Kobza, Leonhard Held, Simon F. Staempfli
Summary: This study provides evidence that impairment in renal function is associated with an increased risk of death and heart transplantation in LVNC patients, suggesting that kidney function assessment should be standard in risk assessment of LVNC patients.
CARDIOLOGY JOURNAL
(2023)
Review
Oncology
Felix Schmidt, Dario Kohlbrenner, Stefan Malesevic, Alice Huang, Sabine D. Klein, Milo A. Puhan, Malcolm Kohler
Summary: Lung cancer is the leading cause of global cancer death, mainly due to late-stage detection. Low-dose CT screening provides an initial clinical solution, but further innovations are needed to overcome limitations. Breath analysis (BA) has great potential as a non-invasive and fast technology to supplement low-dose CT, but its adoption in clinical practice is limited. This scoping review provides a comprehensive summary of BA methods and biomarkers in lung cancer, and offers a framework for future research and translation into clinical workflows.
Article
Infectious Diseases
Aline Wolfensberger, Lauren Clack, Stefanie von Felten, Mirjam Faes Hesse, Dirk Saleschus, Marie-Theres Meier, Katharina Kusejko, Roger Kouyos, Leonhard Held, Hugo Sax
Summary: This study aimed to test a prevention intervention for non-ventilator-associated hospital-acquired pneumonia and a multifaceted implementation strategy. The results showed that implementing the prevention intervention significantly reduced the incidence rate of nvHAP.
LANCET INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Manja Deforth, Charlotte Micheloud, Kit C. Roes, Leonhard Held
Summary: Conditional or accelerated approval of drugs allows earlier access to promising new treatments that address unmet medical needs. Traditional methods like Fisher's criterion and Stouffer's method can be used to support the design and analysis of post-market trials, but the harmonic mean chi(2)-test always requires a post-market clinical trial and may require a smaller sample size if the p-value from the pre-market clinical trial is << 0.025.
PHARMACEUTICAL STATISTICS
(2023)
Article
Medicine, General & Internal
Tala Ballouz, Dominik Menges, Alexia Anagnostopoulos, Anja Domenghino, Helene E. Aschmann, Anja Frei, Jan S. Fehr, Milo A. Puhan
Summary: This study evaluated longer term symptoms and health outcomes associated with a SARS-CoV-2 infection. The results showed that 22.9% of individuals infected with SARS-CoV-2 did not fully recover by six months, but the proportion decreased to 17.2% at 24 months. Most participants had continued recovery or overall improvement over time, while a small percentage had worsening or alternating periods. The prevalence and severity of COVID-19 related symptoms also decreased over time, with 18.1% reporting symptoms at 24 months. Infected individuals had higher symptom risk compared with controls at six months.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Clinical Neurology
Mina Stanikic, Eric Twomey, Milo A. Puhan, Christian P. Kamm, Anke Salmen, Vladeta Ajdacic-Gross, Chiara Zecca, Claudio Gobbi, Viktor von Wyl
Summary: The Swiss MS Registry conducted a survey on Covid-19 vaccine hesitancy, self-reported side effects, and changes in MS symptoms among people with MS. The results showed that vaccine hesitancy was low, and younger individuals, those with a history of Covid-19 infection, and those without regular contact with healthcare professionals were more likely to be hesitant.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
Sabatini Serena, Pacifico Deborah, Frei Anja, Graf Gwendolyn, Milo A. Puhan, Emiliano Albanese
Summary: This study aimed to investigate the impact of COVID-19 infection on cognitive functioning. It found that serologically confirmed COVID-19 infection was associated with cognitive decline. Participants who received COVID-19 vaccination had better cognitive functioning, while those with a history of infection had poorer cognitive functioning. This study strengthens the evidence of COVID-19-related cognitive decline and highlights the importance of addressing it in clinical and public health areas.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Oliver Burzle, Dominik Menges, Julian D. Maier, Daniel Schams, Milo A. Puhan, Jan Fehr, Tala Ballouz, Anja Frei
Summary: Effective vaccination strategies are crucial for long-term control of SARS-CoV-2, but vaccine hesitancy and misinformation pose challenges. This study examined the experiences of 575 adults following vaccination and found that most participants reported mild or moderate adverse effects within 12 weeks, which resolved within three days and rarely led to severe reactions or hospitalizations.
Article
Pharmacology & Pharmacy
Annette Kopp-Schneider, Manuel Wiesenfarth, Leonhard Held, Silvia Calderazzo
Summary: Borrowing information from historical or external data for inference in current trials is a growing field in precision medicine. This study proposes a procedure to investigate and report the operating characteristics of borrowing methods. The findings suggest that borrowing external data may not improve the power of certain trials.
PHARMACEUTICAL STATISTICS
(2023)
Article
Geriatrics & Gerontology
Deborah Pacifico, Serena Sabatini, Maddalena Fiordelli, Anna Maria Annoni, Anja Frei, Milo Puhan, Gwendolyn Graf, Emiliano Albanese
Summary: The study found that speaking multiple languages and having higher language proficiency were positively associated with better cognitive functioning in community-dwelling older adults, but not in institutionalized older adults. Multilingualism may contribute to cognitive reserve and delay cognitive decline in late life.
Review
Public, Environmental & Occupational Health
Javier Munoz Laguna, Milo A. Puhan, Fernando Rodriguez Artalejo, Robby De Pauw, Grant M. A. Wyper, Brecht Devleesschauwer, Joao V. Santos, Cesar A. Hincapie
Summary: This study describes and assesses the risk of bias of the primary input studies for low back pain, neck pain, and knee osteoarthritis in the Global Burden of Disease Study 2019. It also evaluates the certainty of the modelled prevalence evidence in the GBD study.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Respiratory System
Claudia Steurer-Stey, Kaba Dalla Lana, Alexandra Strassmann, Stefanie Gonin-Spahni, Michelle Borgmann, Ursina Brun del Re, Sebastian Haas, Eliane Sarasin, Andrea Burri, Anja Frei, Milo A. Puhan
Summary: This study aims to develop a tool that facilitates communication and counseling on sexuality in persons with chronic obstructive pulmonary disease (COPD). The survey showed that both patients and healthcare professionals (HCPs) wanted to talk about sexuality, but there were communication barriers in doing so. The developed instrument, COmmunication about SexualitY in COPD (COSY), consists of four tools to help address these barriers and promote a more holistic consideration of quality of life.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2023)
Article
Public, Environmental & Occupational Health
Anja Domenghino, Roxane Diane Staiger, Fariba Abbassi, Miquel Serra-Burriel, Kim Leutwyler, Guillaume Aeby, Matthias Turina, Christian Alexander Gutschow, Pierre-Alain Clavien, Milo Alan Puhan
Summary: This study compared patient selection and postoperative outcomes for gastrointestinal surgeries before and during the SARS-CoV-2 pandemic. The results showed a reduction in caseload during certain periods, but no significant decrease in overall procedures. The population characteristics differed, with lower Body Mass Indices and more patients smoking and having diabetes in 2020. Delivering surgical care to COVID-19 patients in the same hospital was found to be safe, and healthcare officials should consider continuing surgical care during future health crises.
INTERNATIONAL JOURNAL OF PUBLIC HEALTH
(2023)
Article
Cardiac & Cardiovascular Systems
Frances M. Wang, Henock G. Yebyo, Shoshana H. Ballew, Miguel Cainzos-Achirica, Cynthia Boyd, Milo A. Puhan, Kunihiro Matsushita, Michael J. Blaha, Nancy L. Schoenborn
Summary: Personalizing preventive therapies for atherosclerotic cardiovascular disease (ASCVD) is crucial for older adults who have multiple chronic conditions and may have different preferences when considering health outcomes. However, little is known about outcome preferences related to ASCVD preventive therapies in older adults.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Public, Environmental & Occupational Health
Marta Fadda, Matilde Melotto, Maria Caiata-Zufferey, Milo Alan Puhan, Anja Frei, Emiliano Albanese, Anne-Linda Camerini
Summary: This scoping review maps the evidence of COVID-19 lockdown impact on parents of children and adolescents, identifying affected parenting domains, describing challenges and opportunities, and defining factors modulating the effect of lockdown measures.
PUBLIC HEALTH REVIEWS
(2023)