Article
Health Care Sciences & Services
Niels Bergsland, Laura Pelizzari, Maria Marcella Lagana, Sonia Di Tella, Federica Rossetto, Raffaello Nemni, Mario Clerici, Francesca Baglio
Summary: This study demonstrates robust and clinically meaningful associations between substantia nigra microstructure and Parkinson's disease, particularly showing a significant correlation between axial diffusivity in SNpc and UPDRS III scores in PD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zexuan Hu, Peng Sun, Ajit George, Xiangling Zeng, Mengyan Li, Tsen-Hsuan Lin, Zezhong Ye, Xinhua Wei, Xinqing Jiang, Sheng-Kwei Song, Ruimeng Yang
Summary: Using diffusion basis spectrum imaging (DBSI) to examine the microstructural changes in the substantia nigra (SN) and global white matter (WM) tracts of patients with early-stage PD. The results showed that DBSI could potentially detect and quantify inflammatory cell infiltration, fiber/dendrite loss, and edema in both SN and WM tracts in patients with early-stage PD.
EUROPEAN RADIOLOGY
(2023)
Article
Clinical Neurology
Sonoko Oshima, Yasutaka Fushimi, Tomohisa Okada, Satoshi Nakajima, Yusuke Yokota, Atsushi Shima, John Grinstead, Sinyeob Ahn, Nobukatsu Sawamoto, Ryosuke Takahashi, Yuji Nakamoto
Summary: The study assessed a new MRI imaging technique that can visualize neuromelanin in the substantia nigra with high resolution in a short scan time, showing potential for evaluating Parkinson's disease.
MOVEMENT DISORDERS
(2021)
Article
Biochemistry & Molecular Biology
Bok-Seok Kim, Taeik Jang, Sung-Eun Yoo, Jae Moon Lee, Eunhee Kim
Summary: The impairment of protein clearance mechanisms in dopaminergic neurons leads to the accumulation of alpha-synuclein, contributing to the pathogenesis of Parkinson's disease. Fas-associated factor 1 (FAF1) was found to disrupt alpha-synuclein clearance through the autophagy-lysosome pathway, indicating a novel role as a negative regulator of autophagic alpha-synuclein clearance. This disturbance ultimately leads to alpha-synuclein accumulation and autophagy dysregulation in PD model mice.
Article
Neuroimaging
Samantha Tan, Septian Hartono, Thomas Welton, Chu Ning Ann, Soo Lee Lim, Tong San Koh, Huihua Li, Fiona Setiawan, Samuel Ng, Nicole Chia, Saifeng Liu, E. Mark Haacke, Eng King Tan, Louis Chew Seng Tan, Ling Ling Chan
Summary: QSM and DKI are complementary tools that provide valuable insights into the complex pathological changes in early Parkinson's disease, particularly in relation to iron deposition and microstructural alterations. These technologies have the potential to be clinically useful for early diagnosis and assessment of PD.
NEUROIMAGE-CLINICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Hee Sung, Joong-Seok Kim, Sang-Won Yoo, Na-Young Shin, Yoonho Nam, Tae-Beom Ahn, Dallah Yoo, Kyung Mi Lee, Hyug-Gi Kim, Seong-Beom Koh, Jinhee Kim, Ilsoo Kim, Do-Young Kwon, Younghen Lee, Chulhan Kim, Sun Ju Chung, Sungyang Jo, Seung Hyun Lee, Sang Joon Kim, Minjae Kim, Chul Hyoung Lyoo, Min Seok Baek, Suk Yun Kang, Suk Ki Chang, Sang-Won Jo, Seun Ah Lee, Hyeo-il Ma, Young Eun Kim, Eun Soo Kim, Yun Joong Kim, Hyun Sook Kim, Min-Hee Woo, Hye Jeong Choi, Eung Yeop Kim
Summary: This study compared the diagnostic performance of susceptibility map-weighted imaging (SMwI) using different MRI machines with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophenyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism. The results showed that SMwI had a high diagnostic sensitivity, specificity, and accuracy, and there was no significant difference between the results of SMwI and F-18-FP-CIT PET. The study demonstrated the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism in a multi-centre setting.
EUROPEAN RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pyeong Hwa Kim, Da Hyun Lee, Chong Hyun Suh, Minjae Kim, Woo Hyun Shim, Sang Joon Kim
Summary: Loss of nigral hyperintensity on SWI can accurately differentiate idiopathic Parkinson's disease or primary parkinsonism from a healthy/disease control group. However, the proportion of non-diagnostic scans is not negligible and must be considered.
EUROPEAN RADIOLOGY
(2021)
Article
Biophysics
Lei Wang, Xin Liu, Shuohua Wu, Fang Chen, Ye Zheng, Gang Guo, Yinghua Xuan, Gen Yan
Summary: This study utilized DKI to detect changes in brain microstructure in PD patients and found that DKI could be a novel tool for qualitative diagnosis of PD, with MK showing high diagnostic efficacy in substantia nigra PD diagnosis.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2021)
Article
Neurosciences
Yanchao Dong, Defeng Liu, Yuemei Zhao, Yi Yuan, Wenxi Wang, Shuo Wu, Xin Liang, Zhanqiu Wang, Lanxiang Liu
Summary: The study demonstrated that LITUS had neuroprotective effects on hemi-PD rats and could reduce neurotoxic damage induced by 6-OHDA. The combination of FA and T2* assessments may serve as a new and effective method to evaluate the therapeutic effects of LITUS.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Xingxing Jian, Guihu Zhao, He Chen, Yanhui Wang, Jinchen Li, Lu Xie, Bin Li
Summary: This study utilized transcriptomics analysis to identify several hub DEGs between PD patients and normal controls, showing high correlations among these genes. A Cox model with an eight-gene signature was constructed to predict PD progression and survival successfully in an independent dataset, highlighting the clinical significance of these findings.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Clinical Neurology
Nandakumar Nagaraja
Summary: DWI is a widely used imaging technique for evaluating patients with stroke, but it has potential pitfalls to be recognized, such as false negative results and ischemic stroke mimics that may occur during interpretation. Advanced diffusion imaging techniques like Diffusion Kurtosis Imaging and Diffusion Tensor Imaging are being studied to evaluate ischemic core.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Alexandra Sobczak, Stefan Repplinger, Eva M. Bauch, Norbert Brueggemann, Christina Lohse, Hermann Hinrichs, Lars Buentjen, Juergen Voges, Tino Zaehle, Nico Bunzeck
Summary: The results from intracranial electroencephalography recordings show that anticipating both positive and negative social feedback accelerates response times in healthy young and older adults, while the effect in operated Parkinson's Disease (PD) patients may be influenced by small sample size. The behavioral effect in non-operated PD patients is not modulated by medication status, indicating that processes other than dopaminergic neuromodulation play a role in driving invigoration by social incentives.
Article
Neurosciences
Mojtaba Jokar, Zhijia Jin, Pei Huang, Ying Wang, Youmin Zhang, Yan Li, Zenghui Cheng, Yu Liu, Rongbiao Tang, Xiaofeng Shi, Jihua Min, Fangtao Liu, Shengdi Chen, Naying He, E. Mark Haacke, Fuhua Yan
Summary: This study developed a comprehensive imaging biomarker for diagnosing Parkinson's disease by using a template-based, automatic segmentation method to detect the features of neuromelanin and iron in the substantia nigra. The combination of the N1 sign with other quantitative measures significantly improved the accuracy of Parkinson's disease diagnosis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jiyoon Yoo, Leevi Kerkela, Patrick W. Hales, Kiran K. Seunarine, Christopher A. Clark
Summary: This study successfully implemented a multidimensional diffusion-encoding protocol to image the microstructure of the healthy hippocampus at high resolution, revealing orientation dispersion in hippocampal tissue. The reproducibility of q-space trajectory imaging metrics was comparable to DTI, providing reference values for microstructural metrics in the healthy hippocampus.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Melanie A. Matyi, Jeffrey M. Spielberg
Summary: Deficits in negative emotion differentiation are associated with mental health outcomes, but the processes underlying individual differences in negative emotion differentiation are poorly understood. This study examines the relationship between white matter microstructure and negative emotion differentiation, providing insights into its component processes and its link to brain structure.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Multidisciplinary Sciences
Leland S. Hu, Lujia Wang, Andrea Hawkins-Daarud, Jennifer M. Eschbacher, Kyle W. Singleton, Pamela R. Jackson, Kamala Clark-Swanson, Christopher P. Sereduk, Sen Peng, Panwen Wang, Junwen Wang, Leslie C. Baxter, Kris A. Smith, Gina L. Mazza, Ashley M. Stokes, Bernard R. Bendok, Richard S. Zimmerman, Chandan Krishna, Alyx B. Porter, Maciej M. Mrugala, Joseph M. Hoxworth, Teresa Wu, Nhan L. Tran, Kristin R. Swanson, Jing Li
Summary: The study developed a radiogenomics machine learning model to quantify uncertainty and predict EGFR amplification status, aiming to address intratumoral genetic heterogeneity and improve personalized therapeutic paradigms. The model used probability distributions to quantify uncertainty for each sample prediction and implemented transductive learning to reduce overall uncertainty.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Maurizio Bergamino, Ryan R. Walsh, Ashley M. Stokes
Summary: Standard DTI and FW-DTI both showed decreased FA in AD, but higher AxD and RD were observed with standard DTI. The FW index was significantly elevated in AD, emphasizing the impact of free water on standard DTI in neurodegenerative pathologies. FW-DTI provided improved consistency in DTI metrics related to WM integrity in Alzheimer's disease.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Ashley M. Stokes, Maurizio Bergamino, Lea Alhilali, Leland S. Hu, John P. Karis, Leslie C. Baxter, Laura C. Bell, C. Chad Quarles
Summary: By comparing dual-echo acquisitions with standard double-dose single-echo acquisitions, the study shows similar rCBV results, suggesting a potential reduction in contrast agent dose with significant pulse sequence flexibility and complementary tumor perfusion and permeability metrics.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ashley M. Stokes, Sudarshan Ragunathan, Ryan K. Robison, Alberto Fuentes, Laura C. Bell, John P. Karis, James G. Pipe, C. Chad Quarles
Summary: The spiral-SAGE method demonstrates substantial improvements in image quality and quantification of perfusion and permeability, especially compared to conventional EPI-SAGE. Bioreactor phantom data show comparable dynamics between spiral-SAGE and EPI-SAGE, with improvements in quantifying T-1 changes. In a cohort of brain tumor patients, spiral-SAGE-based perfusion and permeability maps provide valuable insights for clinical assessment.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Neurosciences
Dietmar Cordes, Muhammad F. Kaleem, Zhengshi Yang, Xiaowei Zhuang, Tim Curran, Karthik R. Sreenivasan, Virendra R. Mishra, Rajesh Nandy, Ryan R. Walsh
Summary: This study used Empirical Mode Decomposition (EMD) to investigate the frequency bands of functional networks in resting-state data, finding that EMD provides a more frequency-adaptive representation compared to traditional methods. Energy-period profiles showed that EMD had significant advantages in classifying NC and PD subjects and characterizing brain networks.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychology, Clinical
Brooks B. Brodrick, Adrienne L. Adler-Neal, Jayme M. Palka, Virendra Mishra, Sina Aslan, Carrie J. McAdams
Summary: Recovering from anorexia nervosa in adult women involves sustained weight restoration, which is crucial for repairing brain structures associated with impulsivity, attention, and other neuropsychological processes. By studying the changes in brain structure at different physiological stages, we gain a better understanding of the recovery process from anorexia nervosa.
JOURNAL OF EATING DISORDERS
(2021)
Article
Neurosciences
Maurizio Bergamino, Elizabeth G. Keeling, Leslie C. Baxter, Nicholas J. Sisco, Ryan R. Walsh, Ashley M. Stokes
Summary: The study investigates the differences in grey matter (GM) volume and white matter (WM) microstructural disorganization between males and females with Alzheimer's disease (AD) using voxel-based morphometry (VBM) and free-water-corrected diffusion tensor imaging (FW-DTI). The results show significant group and sex differences, and post-hoc comparisons reveal that AD is associated with reduced GM volume, reduced FW-FA, and higher FW-RD/FW-index, consistent with neurodegeneration. Females in both groups exhibit higher GM volume than males, while FW-DTI metrics show sex differences only in the AD group.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura C. Bell, Alberto E. Fuentes, Deborah R. Healey, Renee Chao, Nadine Bakkar, Rachael W. Sirianni, David X. Medina, Robert P. Bowser, Shafeeq S. Ladha, Natenael B. Semmineh, Ashley M. Stokes, C. Chad Quarles
Summary: The T-2* relaxivity contrast imaging can potentially be used as an imaging biomarker for ALS by quantifying tissue microstructure. In a longitudinal study comparing ALS model rats with a control group, changes in muscle tissue microstructure were observed, supporting the potential of T-2* relaxivity contrast imaging as a biomarker for disease progression in ALS patients.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Clinical Neurology
Jason K. Longhurst, J. L. Cummings, S. E. John, B. Poston, J. Rider, A. M. Salazar, V. R. Mishra, A. Ritter, J. Z. Caldwell, J. B. Miller, J. W. Kinney, M. R. Landers
Summary: Dual task performance is correlated with amyloidosis, and can be used to predict preclinical Alzheimer's disease and improve diagnostic accuracy.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Correction
Clinical Neurology
J. Sebastian Marquez, S. M. Shafiul Hasan, Masudur R. Siddiquee, Corneliu C. Luca, Virendra R. Mishra, Zoltan Mari, Ou Bai
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Karthik Sreenivasan, Ece Bayram, Xiaowei Zhuang, Jason Longhurst, Zhengshi Yang, Dietmar Cordes, Aaron Ritter, Jessica Caldwell, Jeffrey L. Cummings, Zoltan Mari, Irene Litvan, Brent Bluett, Virendra R. Mishra
Summary: This study investigates the reorganization of resting-state network topology in Parkinson's disease patients with freezing of gait. The results reveal noticeable reorganization of hub regions and significantly altered feeder and local connectivity in patients with freezing of gait.
JOURNAL OF NEUROIMAGING
(2023)
Meeting Abstract
Clinical Neurology
Virendra Mishra, Aaron Ritter, Charles Bernick
Article
Clinical Neurology
Nicholas J. Sisco, Aimee Borazanci, Richard Dortch, Ashley M. Stokes
Summary: This study found that lesion perfusion is reduced at both the global and capillary level, and capillary-associated hypoperfusion is associated with reduced white matter microstructural integrity in patients with relapsing-remitting multiple sclerosis.
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sudarshan Ragunathan, Laura C. Bell, Natenael Semmineh, Ashley M. Stokes, Jeremy M. Shefner, Robert Bowser, Shafeeq Ladha, C. Chad Quarles
Summary: The study demonstrated that RCI-based TRATE can effectively distinguish ALS-affected muscle from healthy muscle and provide a quantitative measure for longitudinal muscle degeneration.
Article
Radiology, Nuclear Medicine & Medical Imaging
Maurizio Bergamino, Elizabeth G. Keeling, Ryan R. Walsh, Ashley M. Stokes
Summary: This study compared FA maps obtained from different acquisitions and fitting algorithms in AD, MCI, and HCs, and observed varying levels of consistency across different conditions. Higher consistency was seen as the number of diffusion directions increased. Significant differences were found between HC and AD groups in all acquisitions, with differences between HC and MCI groups observed only in certain conditions. AFNI-LLS and CAMINO-RESTORE were identified as the least consistent algorithms. Combining data from multiple acquisitions and fits revealed FA differences in the fornix and corpus callosum may serve as robust DTI-based biomarkers for assessing microstructural changes in AD.