Infections With Extracellular Trypanosomes Require Control by Efficient Innate Immune Mechanisms and Can Result in the Destruction of the Mammalian Humoral Immune System

Mechanistic Similarities between Antigenic Variation and Antibody Diversification during Trypanosoma brucei Infection

(2019) Francisco Aresta-Branco et al.   TRENDS IN PARASITOLOGY

Application of long read sequencing to determine expressed antigen diversity in Trypanosoma brucei infections

(2019) Siddharth Jayaraman et al.   PLoS Neglected Tropical Diseases

NK Cells Are Critical for Optimal Immunity to Experimental Trypanosoma congolense Infection

(2019) Chukwunonso Onyilagha et al.   JOURNAL OF IMMUNOLOGY

Trypanosoma brucei brucei causes a rapid and persistent influx of neutrophils in the spleen of infected mice

(2019) Violette Deleeuw et al.   PARASITE IMMUNOLOGY

The covalent binding story of the complement proteins C3 and C4 (I) 1972-1981

(2019) S.K. Alex Law et al.   IMMUNOBIOLOGY

Host Immune Responses and Immune Evasion Strategies in African Trypanosomiasis

(2019) Chukwunonso Onyilagha et al.   Frontiers in Immunology

Quorum sensing in African trypanosomes

(2019) Federico Rojas et al.   CURRENT OPINION IN MICROBIOLOGY

African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System

(2018) Benoit Stijlemans et al.   Frontiers in Immunology

Immunolocalization and Challenge Studies Using a Recombinant Vibrio cholerae Ghost Expressing Trypanosoma brucei Ca2+ ATPase (TBCA2) Antigen

(2018) Kiantra Ramey et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Neutrophils enhance early Trypanosoma brucei infection onset

(2018) Guy Caljon et al.   Scientific Reports

Oligopeptide Signaling through TbGPR89 Drives Trypanosome Quorum Sensing

(2018) Federico Rojas et al.   CELL

A gene expression comparison of Trypanosoma brucei and Trypanosoma congolense in the bloodstream of the mammalian host reveals species-specific adaptations to density-dependent development

(2018) Eleanor Silvester et al.   PLoS Neglected Tropical Diseases

Salivarian Trypanosomosis: A Review of Parasites Involved, Their Global Distribution and Their Interaction With the Innate and Adaptive Mammalian Host Immune System

(2018) Magdalena Radwanska et al.   Frontiers in Immunology

The role of CR3 (CD11b/CD18) and CR4 (CD11c/CD18) in complement-mediated phagocytosis and podosome formation by human phagocytes

(2017) Szilvia Lukácsi et al.   IMMUNOLOGY LETTERS

Serological tests for gambiense human African trypanosomiasis detect antibodies in cattle

(2017) Enock Matovu et al.   Parasites & Vectors

A quorum sensing-independent path to stumpy development in Trypanosoma brucei

(2017) Henriette Zimmermann et al.   PLoS Pathogens

African Trypanosomes Undermine Humoral Responses and Vaccine Development: Link with Inflammatory Responses?

(2017) Benoit Stijlemans et al.   Frontiers in Immunology

Interspecies quorum sensing in co-infections can manipulate trypanosome transmission potential

(2017) Eleanor Silvester et al.   Nature Microbiology

Maintenance of B cells during chronic murineTrypanosoma brucei gambienseinfection

(2016) J. Cnops et al.   PARASITE IMMUNOLOGY

Prospects for vaccination against pathogenic African trypanosomes

(2016) S. J. Black et al.   PARASITE IMMUNOLOGY

Tolerance to Trypanosomatids: A Threat, or a Key for Disease Elimination?

(2016) David Berthier et al.   TRENDS IN PARASITOLOGY

A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense

(2016) Anneli Cooper et al.   PLoS Neglected Tropical Diseases

Trypanosoma brucei Co-opts NK Cells to Kill Splenic B2 B Cells

(2016) Deborah Frenkel et al.   PLoS Pathogens

Blocking Synthesis of the Variant Surface Glycoprotein Coat in Trypanosoma brucei Leads to an Increase in Macrophage Phagocytosis Due to Reduced Clearance of Surface Coat Antibodies

(2016) Jackie L. Y. Cheung et al.   PLoS Pathogens

An Overview of Trypanosoma brucei Infections: An Intense Host–Parasite Interaction

(2016) Alicia Ponte-Sucre   Frontiers in Microbiology

Assembling the components of the quorum sensing pathway in African trypanosomes

(2015) Binny M. Mony et al.   MOLECULAR MICROBIOLOGY

IFN-γ mediates early B-cell loss in experimental African trypanosomosis

(2015) J. Cnops et al.   PARASITE IMMUNOLOGY

Curative drug treatment of trypanosomosis leads to the restoration of B-cell lymphopoiesis and splenic B-cell compartments

(2015) J. Cnops et al.   PARASITE IMMUNOLOGY

Protective antibody and cytokine responses in mice following immunization with recombinant beta-tubulin and subsequent Trypanosoma evansi challenge

(2015) Anup Kumar Tewari et al.   Parasites & Vectors

The within-host dynamics of African trypanosome infections

(2015) Keith R. Matthews et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The in vivo dynamics of antigenic variation in Trypanosoma brucei

(2015) M. R. Mugnier et al.   SCIENCE

The B Cell Adaptor Molecule Bam32 Is Critically Important for Optimal Antibody Response and Resistance to Trypanosoma congolense Infection in Mice

(2015) Chukwunonso Onyilagha et al.   PLoS Neglected Tropical Diseases

How Does the VSG Coat of Bloodstream Form African Trypanosomes Interact with External Proteins?

(2015) Angela Schwede et al.   PLoS Pathogens

NK-, NKT- and CD8-Derived IFNγ Drives Myeloid Cell Activation and Erythrophagocytosis, Resulting in Trypanosomosis-Associated Acute Anemia

(2015) Jennifer Cnops et al.   PLoS Pathogens

Antigenic variation in African trypanosomes

(2014) David Horn   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

The molecular arms race between African trypanosomes and humans

(2014) Etienne Pays et al.   NATURE REVIEWS MICROBIOLOGY

Antibody-mediated control ofTrypanosoma vivaxinfection fails in the absence of tumour necrosis factor

(2014) F. La Greca et al.   PARASITE IMMUNOLOGY

ChronicTrypanosoma congolenseinfections in mice cause a sustained disruption of the B-cell homeostasis in the bone marrow and spleen

(2014) E. Obishakin et al.   PARASITE IMMUNOLOGY

A co-evolutionary arms race: trypanosomes shaping the human genome, humans shaping the trypanosome genome

(2014) PAUL CAPEWELL et al.   PARASITOLOGY

Unravelling Human Trypanotolerance: IL8 is Associated with Infection Control whereas IL10 and TNFα Are Associated with Subsequent Disease Development

(2014) Hamidou Ilboudo et al.   PLoS Pathogens

Gambiense Human African Trypanosomiasis and Immunological Memory: Effect on Phenotypic Lymphocyte Profiles and Humoral Immunity

(2014) Veerle Lejon et al.   PLoS Pathogens

Genome-wide dissection of the quorum sensing signalling pathway in Trypanosoma brucei

(2013) Binny M. Mony et al.   NATURE

Mosaic VSGs and the Scale of Trypanosoma brucei Antigenic Variation

(2013) James P. J. Hall et al.   PLoS Pathogens

The TgsGP Gene Is Essential for Resistance to Human Serum in Trypanosoma brucei gambiense

(2013) Paul Capewell et al.   PLoS Pathogens

Effect of adjuvants on the humoral immune response to congopain in mice and cattle

(2012) John Kateregga et al.   BMC Veterinary Research

Trypanosome resistance to human innate immunity: targeting Achilles’ heel

(2012) Natalie A. Stephens et al.   TRENDS IN PARASITOLOGY

Induction of protective immune response in mice by a DNA vaccine encoding Trypanosoma evansi beta tubulin gene

(2012) Samarchith P. Kurup et al.   VETERINARY PARASITOLOGY

Haptoglobin-hemoglobin receptor independent killing of African trypanosomes by human serum and trypanosome lytic factors

(2012) Whitney Bullard et al.   Virulence

Sialidases play a key role in infection and anaemia in Trypanosoma congolense animal trypanosomiasis

(2011) Virginie Coustou et al.   CELLULAR MICROBIOLOGY

Vaccination against trypanosomiasis

(2011) Florencia La Greca et al.   Human vaccines & immunotherapeutics

T. brucei Infection Reduces B Lymphopoiesis in Bone Marrow and Truncates Compensatory Splenic Lymphopoiesis through Transitional B-Cell Apoptosis

(2011) Viki Bockstal et al.   PLoS Pathogens

Trypanosoma brucei: Immunisation with plasmid DNA encoding invariant surface glycoprotein gene is able to induce partial protection in experimental African trypanosomiasis

(2010) Andreia Sofia Cruz Lança et al.   EXPERIMENTAL PARASITOLOGY

Interleukin-17-Mediated Control of Parasitemia in Experimental Trypanosoma congolense Infection in Mice

(2010) Z. Mou et al.   INFECTION AND IMMUNITY

Low Specificities of HIV Diagnostic Tests Caused by Trypanosoma brucei gambiense Sleeping Sickness

(2010) V. Lejon et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Intradermal Infections of Mice by Low Numbers of African Trypanosomes Are Controlled by Innate Resistance but Enhance Susceptibility to Reinfection

(2010) Guojian Wei et al.   JOURNAL OF INFECTIOUS DISEASES

Trypanosoma vivax Infections: Pushing Ahead with Mouse Models for the Study of Nagana. II. Immunobiological Dysfunctions

(2010) Marie Christine Blom-Potar et al.   PLoS Neglected Tropical Diseases

Activity of trypanosome lytic factor: a novel component of innate immunity

(2009) Russell Thomson et al.   Future Microbiology

Processing and Presentation of Variant Surface Glycoprotein Molecules to T Cells in African Trypanosomiasis

(2009) T. R. Dagenais et al.   JOURNAL OF IMMUNOLOGY

The trypanosome flagellar pocket

(2009) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Induction and regulation of Trypanosoma brucei VSG-specific antibody responses

(2009) S. J. BLACK et al.   PARASITOLOGY

Trans-sialidase from Trypanosoma brucei as a potential target for DNA vaccine development against African trypanosomiasis

(2009) Marcelo Sousa Silva et al.   PARASITOLOGY RESEARCH

Immune responses to haemorrhagic septicaemia (HS) vaccination in Trypanosoma evansi infected buffalo-calves

(2009) Lachhman D. Singla et al.   TROPICAL ANIMAL HEALTH AND PRODUCTION

Modulation of the immunogenicity of theTrypanosoma congolensecysteine protease, congopain, through complexation with α2-macroglobulin

(2009) Laura Elizabeth Joan Huson et al.   VETERINARY RESEARCH

T-Cell Responses to the Trypanosome Variant Surface Glycoprotein Are Not Limited to Hypervariable Subregions

(2008) T. R. Dagenais et al.   INFECTION AND IMMUNITY

Immunization with recombinant actin from Trypanosoma evansi induces protective immunity against T. evansi, T. equiperdum and T. b. brucei infection

(2008) San-Qiang Li et al.   PARASITOLOGY RESEARCH

Trypanosomiasis-Induced B Cell Apoptosis Results in Loss of Protective Anti-Parasite Antibody Responses and Abolishment of Vaccine-Induced Memory Responses

(2008) Magdalena Radwanska et al.   PLoS Pathogens

The Role of B-cells and IgM Antibodies in Parasitemia, Anemia, and VSG Switching in Trypanosoma brucei–Infected Mice

(2008) Stefan Magez et al.   PLoS Pathogens