An injectable microparticle formulation for the sustained release of the specific MEK inhibitor PD98059: in vitro evaluation and pharmacokinetics
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An injectable microparticle formulation for the sustained release of the specific MEK inhibitor PD98059: in vitro evaluation and pharmacokinetics
Authors
Keywords
-
Journal
Drug Delivery and Translational Research
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-05-07
DOI
10.1007/s13346-020-00758-9
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Targeting the ERK Signaling Pathway in Melanoma
- (2019) Paola Savoia et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Update on BRAF and MEK inhibition for treatment of melanoma in metastatic, unresectable, and adjuvant settings
- (2019) Kristy Kummerow Broman et al. Expert Opinion On Drug Safety
- Development of ERK1/2 inhibitors as a therapeutic strategy for tumour with MAPK upstream target mutations
- (2019) Miao Longfei et al. JOURNAL OF DRUG TARGETING
- The extended spectrum of RAS‐MAPK pathway mutations in colorectal cancer
- (2019) Danielle C. Costigan et al. GENES CHROMOSOMES & CANCER
- Assessing Therapeutic Efficacy of MEK Inhibition in a KRAS G12C-Driven Mouse Model of Lung Cancer
- (2018) Shuai Li et al. CLINICAL CANCER RESEARCH
- Sustained exenatide delivery via intracapsular microspheres for improved survival and function of microencapsulated porcine islets
- (2018) Benjamin Lew et al. Drug Delivery and Translational Research
- Development of in vitro-in vivo correlation of parenteral naltrexone loaded polymeric microspheres
- (2017) Janki V. Andhariya et al. JOURNAL OF CONTROLLED RELEASE
- Current Development Status of MEK Inhibitors
- (2017) et al. MOLECULES
- Inhibition of the MEK/ERK pathway augments nab-paclitaxel-based chemotherapy effects in preclinical models of pancreatic cancer
- (2017) Niranjan Awasthi et al. Oncotarget
- Endoplasmic reticulum stress increases brain MAPK signaling, inflammation and renin-angiotensin system activity and sympathetic nerve activity in heart failure
- (2016) Shun-Guang Wei et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- ERK1/2 MAPK signaling in hypothalamic paraventricular nucleus contributes to sympathetic excitation in rats with heart failure after myocardial infarction
- (2016) Yang Yu et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC
- (2016) Lei Li et al. Oncology Letters
- Preparation, characterization, and in vitro release studies of insulin-loaded double-walled poly(lactide-co-glycolide) microspheres
- (2016) Rezaul H. Ansary et al. Drug Delivery and Translational Research
- Synthesis, Characterization, and In Vitro and In Vivo Evaluations of 4-(N)-Docosahexaenoyl 2′, 2′-Difluorodeoxycytidine with Potent and Broad-Spectrum Antitumor Activity
- (2016) Youssef W. Naguib et al. NEOPLASIA
- Inhibition of Brain Mitogen-Activated Protein Kinase Signaling Reduces Central Endoplasmic Reticulum Stress and Inflammation and Sympathetic Nerve Activity in Heart Failure RatsNovelty and Significance
- (2015) Shun-Guang Wei et al. HYPERTENSION
- Diaminosulfide based polymer microparticles as cancer vaccine delivery systems
- (2015) Sean M. Geary et al. JOURNAL OF CONTROLLED RELEASE
- MEK1/2 Inhibitors: Molecular Activity and Resistance Mechanisms
- (2015) Pui-Kei Wu et al. SEMINARS IN ONCOLOGY
- Clinical Pharmacokinetics of Drugs in Patients with Heart Failure: An Update (Part 2, Drugs Administered Orally)
- (2014) Ryuichi Ogawa et al. CLINICAL PHARMACOKINETICS
- “RAF” neighborhood: Protein-protein interaction in the Raf/Mek/Erk pathway
- (2014) Botond Cseh et al. FEBS LETTERS
- Combination treatment of PD98059 and DAPT in gastric cancer through induction of apoptosis and downregulation of WNT/β-catenin
- (2013) Jun Yao et al. CANCER BIOLOGY & THERAPY
- Early Interference With p44/42 Mitogen-Activated Protein Kinase Signaling in Hypothalamic Paraventricular Nucleus Attenuates Angiotensin II–Induced Hypertension
- (2013) Yang Yu et al. HYPERTENSION
- Targeting RAS/RAF/MEK/ERK signaling in metastatic melanoma
- (2013) Ao-Xue Wang et al. IUBMB LIFE
- MEK in cancer and cancer therapy
- (2013) Cindy Neuzillet et al. PHARMACOLOGY & THERAPEUTICS
- Central Actions of the Chemokine Stromal Cell-Derived Factor 1 Contribute to Neurohumoral Excitation in Heart Failure Rats
- (2012) Shun-Guang Wei et al. HYPERTENSION
- Aldosterone-induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent
- (2011) Zhi-Hua Zhang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- GSK1120212 (JTP-74057) Is an Inhibitor of MEK Activity and Activation with Favorable Pharmacokinetic Properties for Sustained In Vivo Pathway Inhibition
- (2011) A. G. Gilmartin et al. CLINICAL CANCER RESEARCH
- Prednisolone-Loaded PLGA Microspheres. In Vitro Characterization and In Vivo Application in Adjuvant-Induced Arthritis in Mice
- (2010) Khaled A. Khaled et al. AAPS PHARMSCITECH
- PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel
- (2010) Yong Zhang et al. COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
- Angiotensin II upregulates hypothalamic AT1 receptor expression in rats via the mitogen-activated protein kinase pathway
- (2009) Shun-Guang Wei et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Pharmacological Treatment for Heart Failure: A View From the Brain
- (2009) R B Felder et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Fabrication, characterization and in vitro evaluation of poly(D,L-lactide-co-glycolide) microparticles loaded with polyamidoamine–plasmid DNA dendriplexes for applications in nonviral gene delivery
- (2009) Janjira Intra et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Nanoparticle-mediated targeting of MAPK signaling predisposes tumor to chemotherapy
- (2009) S. Basu et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Design of Methylprednisolone Biodegradable Microspheres Intended for Intra-articular Administration
- (2008) Francesco Cilurzo et al. AAPS PHARMSCITECH
- Inhibition of brain proinflammatory cytokine synthesis reduces hypothalamic excitation in rats with ischemia-induced heart failure
- (2008) Yu-Ming Kang et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Mitogen-Activated Protein Kinases Mediate Upregulation of Hypothalamic Angiotensin II Type 1 Receptors in Heart Failure Rats
- (2008) Shun-Guang Wei et al. HYPERTENSION
- Angiotensin II–Triggered p44/42 Mitogen-Activated Protein Kinase Mediates Sympathetic Excitation in Heart Failure Rats
- (2008) Shun-Guang Wei et al. HYPERTENSION
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now