Journal
ADVANCED SCIENCE
Volume 7, Issue 12, Pages -Publisher
WILEY
DOI: 10.1002/advs.202000370
Keywords
bioimaging; cytocompatibility; flame spray pyrolysis; intravital microscopy; Mn5+-doped Ba-3(PO4)(2)
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Funding
- Particle Technology Laboratory
- ETH Zurich Research Grant [ETH-43 17-1]
- Swiss National Science Foundation [206021_177037]
- Swiss National Science Foundation (Eccellenza) [PCEFP2_181290]
- Swiss National Science Foundation (SNF) [206021_177037, PCEFP2_181290] Funding Source: Swiss National Science Foundation (SNF)
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Bright, stable, and biocompatible fluorescent contrast agents operating in the second biological window (1000-1350 nm) are attractive for imaging of deep-lying structures (e.g., tumors) within tissues. Ideally, these contrast agents also provide functional insights, such as information on local temperature. Here, water-dispersible barium phosphate nanoparticles doped with Mn5+ are made by scalable, continuous, and sterile flame aerosol technology and explored as fluorescent contrast agents with temperature-sensitive peak emission in the NIR-II (1190 nm). Detailed assessment of their stability, toxicity with three representative cell lines (HeLa, THP-1, NHDF), and deep-tissue imaging down to about 3 cm are presented. In addition, their high quantum yield (up to 34%) combined with excellent temperature sensitivity paves the way for concurrent deep-tissue imaging and nanothermometry, with biologically well-tolerated nanoparticles.
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