Article
Oncology
Zhonghui Hu, Wenbo Wu, Xiaopeng Zhang, Ping Li, Hua Zhang, Huien Wang, Wenfei Xue, Zhiguo Chen, Qingtao Zhao, Guochen Duan
Summary: This study aimed to explore the relationship between the Advanced Lung Cancer Inflammation Index (ALI) and the prognosis of operable Small-Cell Lung Cancer (SCLC). The results showed that low ALI was correlated with poor prognosis in patients with operable SCLC who underwent surgery, indicating that preoperative ALI might serve as a potential prognostic marker for these patients.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Oncology
Junjie Hu, Yan Chen, Xinsheng Zhu, Qiang Ma, Jing Zhang, Gening Jiang, Peng Zhang
Summary: For patients with non-small cell lung cancer and unexpected pleural dissemination, resection of the main tumor and visible pleural nodules can improve prognosis, especially for those who cannot receive targeted therapy. Sublobar resection without systematic lymphadenectomy may be the optimal procedure.
Article
Cardiac & Cardiovascular Systems
Isamu Watanabe, Aritoshi Hattori, Mariko Fukui, Takeshi Matsunaga, Kazuya Takamochi, Kenji Suzuki
Summary: PA reconstruction without systemic heparinization during resections of NSCLC has a low risk of thrombosis and perioperative bleeding.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biochemical Research Methods
Xingze Wang, Guoxian Yu, Jun Wang, Azlan Mohd Zain, Wei Guo
Summary: Diagnosing lung cancer subtypes accurately is crucial for precise treatment. This study introduces an interpretable and flexible solution called LungDWM, which utilizes weakly paired multiomics data to diagnose lung cancer subtypes. By extracting important diagnostic features, imputing missing data, and fusing information from different omics, LungDWM outperforms other competitive methods in terms of performance, authenticity, and interpretability.
Article
Oncology
Shinkichi Takamori, Mototsugu Shimokawa, Taichi Matsubara, Naoki Haratake, Ryo Toyozawa, Naoko Miura, Masafumi Yamaguchi, Takashi Seto, Tetsuzo Tagawa, Tatsuro Okamoto, Mitsuhiro Takenoyama, Yoshihiko Maehara, Masaki Mori
Summary: The study analyzed 1134 NSCLC patients with smoking history who underwent curative lung resection at a single center in Japan between 2000 and 2016, finding that smoking period was an independent predictor of DFS and OS, with superior AUC values compared to number of packs smoked per day. Patients with a smoking period >= 40 years had significantly shorter DFS and OS than those with a smoking period of < 40 years.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Atsushi Kamigaichi, Keiju Aokage, Shinya Katsumata, Genichiro Ishii, Masashi Wakabayashi, Tomohiro Miyoshi, Kenta Tane, Joji Samejima, Masahiro Tsuboi
Summary: This study evaluated the prognostic impact of examining the number of individual mediastinal lymph nodes (mLNs) in patients with resectable non-small cell lung cancer (NSCLC). The results showed that examining >= 3 mLNs was associated with better prognosis and lower risk of lymph node recurrence.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Surgery
Nozomu Motono, Takaki Mizoguchi, Masahito Ishikawa, Shun Iwai, Yoshihito Iijima, Hidetaka Uramoto
Summary: This study retrospectively evaluated the perioperative characteristics and outcomes of video-assisted thoracic surgery (VATS) for non-small cell lung cancer (NSCLC) over the past decade. The results showed a decrease in postoperative morbidity over time, but no change in prognosis.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Oncology
Luca Bertolaccini, Monica Casiraghi, Giulia Sedda, Filippo de Marinis, Lorenzo Spaggiari
Summary: This systematic review investigated clinical prognostic factors in OM-NSCLC patients treated with radical intent. Positive prognostic factors for survival included smoking cessation, age <60, histologic grade G1/G2, and pN0, while the presence of extra-brain OM and multiple metastases negatively affected survival. Aggressive treatment should be considered for stable OM-NSCLC patients with single organ site extrathoracic M1 disease and no intrathoracic lymph node involvement, even in the absence of randomized evidence.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Hiroki Ozawa, Yosuke Matsuura, Kohei Hashimoto, Junji Ichinose, Masayuki Nakao, Sakae Okumura, Mingyon Mun
Summary: Various calculation models have been developed worldwide to estimate prognosis and predict surgical risk. In this study, we assessed the prognostication of 1054 lung cancer patients using a Japanese model. The results showed that the model's predictions were associated with significantly poorer prognosis and could be a useful tool for multidisciplinary thoracic oncology teams to discuss treatment strategies for high-risk patients.
CLINICAL LUNG CANCER
(2023)
Review
Oncology
Weibo Cao, Quanying Tang, Jingtong Zeng, Xin Jin, Lingling Zu, Song Xu
Summary: This article reviewed the literature to determine the prognostic effect of related indicators on early-stage NSCLC, including mutant genes, immunological checkpoints, and blood-based biomarkers. Artificial intelligence can be applied to construct prognostic models that accurately predict patient survival and guide individualized treatment.
Article
Geriatrics & Gerontology
Mengmeng Song, Qi Zhang, Chunhua Song, Tong Liu, Xi Zhang, Guotian Ruan, Meng Tang, Hailun Xie, Heyang Zhang, Yizhong Ge, Xiangrui Li, Kangping Zhang, Ming Yang, Qinqin Li, Xiaoyue Liu, Shiqi Lin, Yu Xu, Hongxia Xu, Kunhua Wang, Wei Li, Hanping Shi
Summary: This study found that the ALI is the best indicator for predicting OS in lung cancer patients, regardless of gender, smoking status, or age less than 65 years. However, in non-small cell lung cancer and patients aged 65 years or older, the modified Glasgow prognostic score is superior to other indicators; in small cell lung cancer patients, the glucose-to-lymphocyte ratio has better prognostic ability.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Surgery
Joanna Sesti, Jonathan Decker, Jaimie Bell, Andrew Nguyen, Adam Lackey, Amber L. Turner, Patrick Hilden, Subroto Paul
Summary: This study compared the long-term survival and cancer-specific mortality between current and former smokers after lung cancer surgery, finding that current smokers had higher cancer-specific mortality after resection.
WORLD JOURNAL OF SURGERY
(2022)
Review
Oncology
Kai-li Huang, Han-Yu Deng, Mingyu Fan, Qiangqiang Zheng, Shanyu Lin, Daxing Zhu, Qinghua Zhou
Summary: The study suggests that vein-first ligation during lobectomy for non-small cell lung cancer patients can significantly improve overall survival and disease-free survival rates.
Article
Immunology
Zhonghua Zou, Jinping Li, Xiang Ji, Tingxing Wang, Qingqing Chen, Zhengcao Liu, Shengjun Ji
Summary: The Naples Prognostic Score (NPS) is a reliable independent prognostic indicator for resected locally advanced non-small cell lung cancer (LA-NSCLC) patients receiving neoadjuvant treatment. It reflects the nutritional and inflammatory status of the patients and has better predictive ability than other indicators.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Oncology
Lian Yu, Jianlin Xu, Rong Qiao, Hua Zhong, Baohui Han, Runbo Zhong
Summary: The retrospective study analyzed the survival and recurrence patterns of patients with pathological N2 LD-SCLC after radical resection, revealing a better survival rate in patients with single p-N2 compared to multiple p-N2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Tomasz Marjanski, Michal Badocha, Damian Wnuk, Robert Dziedzic, Marcin Ostrowski, Wioletta Sawicka, Witold Rzyman
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2019)
Article
Pathology
Erik Thunnissen, Keith M. Kerr, Urania Dafni, Lukas Bubendorf, Stephen P. Finn, Alex Soltermann, Wojciech Biernat, Richard Cheney, Erik Verbeken, Arne Warth, Antonio Marchetti, Ernst-Jan M. Speel, Saraswati Pokharel, Anne Marie Quinn, Kim Monkhorst, Atilio Navarro, Line Bille Madsen, Zoi Tsourti, Thomas Geiger, Roswitha Kammler, Solange Peters, Rolf A. Stahel, Rafael Rosell, Fiona Blackhall, Miguel Angel Molina, Walter Weder, Stephen Finn, Anita Hiltbrunner, Nesa Marti, Varvara Polydoropoulou, Panagiota Zygoura, Marianne Nicolson, David A. J. Stevenson, William Mathieson, Egbert Smit, Teodora Radonic, Undine Rulle, Alessandra Curioni, Steven G. Gray, Kathy Gately, Martin Barr, Peter Meldgaard, Line B. Madsen, Spasenija Savic, Didier Lardinois, Kristiaan Nackaerts, Christophe Dooms, Els Wauters, Sara van der Borght, Ania Wrona, Witold Rzyman, Jacek Jassem, Hendrik Dienemann, Thomas Muley, Arne Warth, Antonio Marchetti, Graziano De Luca, Alessia di Lorito, Anne-Marie Dingemans, Ernst-Jan M. Speel, Andrea Ruland, Saraswati Pokharel, Richard Cheney, Philip Ferenczy, Anne Marie Quinn, Lynsey Franklin, Paul Baas, Kim Monkhorst, Bart van de Wiel, Carlos Camps, Miguel Martorell, Atilio Navarro
Review
Oncology
Elzbieta Chrusciel, Zuzanna Urban-Wojciuk, Lukasz Arcimowicz, Malgorzata Kurkowiak, Jacek Kowalski, Mateusz Gliwinski, Tomasz Marjanski, Witold Rzyman, Wojciech Biernat, Rafal Dziadziuszko, Carla Montesano, Roberta Bernardini, Natalia Marek-Trzonkowska
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Robert Dziedzic, Witold Rzyman
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2020)
Editorial Material
Oncology
Mariusz Adamek, Wojciech Biernat, Joanna Chorostowska-Wynimko, Joanna A. Didkowska, Katarzyna Dziadziuszko, Tomasz Grodzki, Jacek Jassem, Lucyna Kepka, Dariusz Kowalski, Pawel Krawczyk, Maciej Krzakowski, Jacek Niklinski, Renata Langfort, Wlodzimierz Olszewski, Tadeusz Orlowski, Rodryg Ramlau, Witold Rzyman, Anna Wrona, Marcin Zielinski, Rafal Dziadziuszko
JOURNAL OF THORACIC ONCOLOGY
(2020)
Article
Oncology
Tomasz Marjanski, Damian Wnuk, Robert Dziedzic, Marcin Ostrowski, Wioletta Sawicka, Ewa Marjanska, Witold Rzyman
Summary: Preoperative results of the 6-min walking test help identify high risk of postoperative complications and increased mortality in patients undergoing lobectomy for lung cancer. The value of 500 m in 6MWT can differentiate risk of complications in patients undergoing pneumonectomy. Patients unable to reach 500 m in 6MWT are at high risk of postoperative death, potentially due to increased frequency of postoperative cardiac complications, indicating poor overall survival.
Article
Medicine, General & Internal
Tomasz Marjanski, Damian Wnuk, Robert Dziedzic, Marcin Ostrowski, Wioletta Sawicka, Witold Rzyman
Summary: The 6-minute walk test before a lobectomy can help identify patients at high risk of postoperative complications, and the results show that patients who do not reach the distance of 500 meters have a higher risk of complications and longer hospital stays.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Piotr Widlak, Karol Jelonek, Agata Kurczyk, Joanna Zyla, Magdalena Sitkiewicz, Edoardo Bottoni, Giulia Veronesi, Joanna Polanska, Witold Rzyman
Summary: Analysis of serum metabolome profiles in two lung cancer screening studies revealed reduced lipid levels in cancer patients, with only a few common cancer-related features identified between the two cohorts. Large heterogeneity in metabolite levels within and between cohorts impaired the accuracy of classification models, suggesting the need for adjustment for lifestyle-related confounding factors in developing metabolite-based biomarkers for early lung cancer detection.
Review
Biochemistry & Molecular Biology
Tomasz Marjanski, Robert Dziedzic, Anna Kowalczyk, Witold Rzyman
Summary: New drugs, such as immune checkpoint inhibitors and targeted therapies, have shown promise in changing the prognosis of some advanced lung cancer patients in neoadjuvant and adjuvant settings. While targeted therapies have proven to be safe in neoadjuvant approach, potential severe respiratory adverse events post-treatment may limit their use in early lung cancer, especially for curative surgery. Further research is needed to assess the feasibility of these therapies in improving outcomes for patients with different stages of lung cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Ines Papak, Elzbieta Chrusciel, Katarzyna Dziubek, Malgorzata Kurkowiak, Zuzanna Urban-Wojciuk, Tomasz Marjanski, Witold Rzyman, Natalia Marek-Trzonkowska
Summary: This article discusses the mechanisms by which NK cells lyse tumor cells and the role of inhibitory signals.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)