Article
Medicine, Research & Experimental
Alexandra J. Berges, Ioan A. Lina, Lena Chen, Rafael Ospino, Ruth Davis, Alexander T. Hillel
Summary: Objective Idiopathic subglottic stenosis (iSGS) diagnosis is often delayed, resulting in additional surgeries, emergency department visits, and hospitalizations for patients. Earlier presentation to otolaryngologist, pulmonary function testing, and CT imaging may expedite iSGS diagnosis.
Article
Medicine, Research & Experimental
Diego E. Razura, Yael Bensoussan, Christopher G. Lui, Michael M. Johns III, Lindsay Reder, Alexander Gelbard, Karla O'Dell
Summary: This study surveyed laryngologists to understand the factors influencing clinical decision-making and the incorporation of new treatment modalities for idiopathic subglottic stenosis (iSGS). The results showed significant variation in patient management, but understanding these decision-making factors may help standardize treatment approaches and improve clinical outcomes.
Review
Biochemistry & Molecular Biology
Alessandro Marchioni, Roberto Tonelli, Alessandro Andreani, Gaia Francesca Cappiello, Matteo Fermi, Fabiana Trentacosti, Ivana Castaniere, Riccardo Fantini, Luca Tabbi, Dario Andrisani, Filippo Gozzi, Giulia Bruzzi, Linda Manicardi, Antonio Moretti, Serena Baroncini, Anna Valeria Samarelli, Massimo Pinelli, Giorgio De Santis, Alessandro Stefani, Daniele Marchioni, Francesco Mattioli, Enrico Clini
Summary: Laryngotracheal stenosis (LTS) is a complex and heterogeneous disease with unclear pathogenesis. Recent research suggests that LTS is a fibroinflammatory event caused by immunological alterations. Factors such as growth factors, cytokines, altered fibroblast function, and genetic susceptibility can interact to result in aberrant and fibrotic wound healing. Additionally, physiological derangement caused by LTS may play a role in promoting dysregulated response to laryngo-tracheal mucosal injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Otorhinolaryngology
Lena W. Chen, Ioan Lina, Kevin Motz, Alexandra J. Berges, Rafael Ospino, Philip Seo, Alexander T. Hillel
Summary: This study analyzed 39 patients with GPA-associated SGS, finding that patients receiving leflunomide had longer dilation intervals. Patients with glottic involvement were more likely to have dysphonia and shorter dilation intervals. The study also found that a subset of patients developed glottic involvement during follow-up visits.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Article
Medicine, General & Internal
Luca Moroni, Laura Giudice, Marco Lanzillotta, Adriana Cariddi, Giuseppe A. Ramirez, Enrica P. Bozzolo, Bruno Germinario, Gabriele Gallina, Stefano Viscardi, Angelo Carretta, Lorenzo Dagna
Summary: This study investigates the role of immunosuppressive treatment on the risk of relapse in patients with subglottic stenosis. The results show that systemic immunosuppression can prevent the recurrence of subglottic stenosis in patients with granulomatosis with polyangiitis.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Edward Ryan R. Talatala, Evan Clark, Wenda Ye, Ruth J. Davis, Alexander T. Hillel, Samuel L. Collins, Marisol Ramirez-Solano, Quanhu Sheng, Alexander Gelbard
Summary: This study aimed to localize cell-specific gene expression of estrogen receptors (ESR1 and ESR2) and progesterone receptor (PGR) using an established iSGS single-cell RNA sequencing (scRNAseq) cell atlas. The results showed differential expression of endocrine receptors in the proximal airway mucosa of iSGS patients and primarily expressed by fibroblasts, immune cells, and endothelial cells in airway scar. These findings provide a foundation for further investigating the role of hormone-dependent mechanisms in iSGS disease pathogenesis.
Article
Medicine, Research & Experimental
Ioan A. Lina, Hsiu-Wen Tsai, Alexandra J. Berges, Rafael A. Ospino, Ruth J. Davis, Kevin M. Motz, Samuel Collins, Baishakhi Ghosh, Venkataramana Sidhaye, Alexander Gelbard, Alexander T. Hillel
Summary: The epithelium in both iSGS and iLTS is morphologically abnormal, with reduced thickness, ciliary cells, and secretory cells. However, only iSGS shows significant increases in pathological basal cell expression. These findings suggest a common role of the epithelium in the pathogenesis of fibrosis in both iSGS and iLTS.
Article
Otorhinolaryngology
William S. Tierney, Li-Ching Huang, Sheau-Chiann Chen, Lynn D. Berry, Catherine Anderson, Milan R. Amin, Michael S. Benninger, Joel H. Blumin, Jonathan M. Bock, Paul C. Bryson, Paul F. Castellanos, Matthew S. Clary, Seth M. Cohen, Brianna K. Crawley, Seth H. Dailey, James J. Daniero, Alessandro de Alarcon, Donald T. Donovan, Eric S. Edell, Dale C. Ekbom, Daniel S. Fink, Ramon A. Franco, Catherine Gaelyn Garrett, Elizabeth A. Guardiani, Alexander T. Hillel, Henry T. Hoffman, Norman D. Hogikyan, Rebecca J. Howell, Michael M. Johns, Jan L. Kasperbauer, Sid M. Khosla, Cheryl Kinnard, Robbi A. Kupfer, Alexander J. Langerman, Robert J. Lentz, Robert R. Lorenz, David G. Lott, Samir S. Makani, Fabien Maldonado, Laura Matrka, Andrew J. McWhorter, Albert L. Merati, Matthew Mori, James L. Netterville, Karla O'Dell, Julina Ongkasuwan, Gregory N. Postma, Lindsay S. Reder, Sarah L. Rohde, Brent E. Richardson, Otis B. Rickman, Clark A. Rosen, Matthew Rohlfing, Michael J. Rutter, Guri S. Sandhu, Joshua S. Schindler, Glenn Todd Schneider, Rupali N. Shah, Andrew G. Sikora, Robert J. Sinard, Marshall E. Smith, Libby J. Smith, Ahmed M. S. Soliman, Sigridur Sveinsdottir, David Veivers, Sunil P. Verma, Paul M. Weinberger, Philip A. Weissbrod, Christopher T. Wootten, Yu Shyr, David O. Francis, Alexander Gelbard
Summary: The North American Airway Collaborative (NoAAC) conducted a 5-year prospective cohort study on treatment effectiveness of three surgical techniques for idiopathic subglottic stenosis (iSGS). The study included 487 iSGS patients and found variations in treatment effectiveness between the different modalities. Cricotracheal resection had the lowest rate of recurrent operation (5%), followed by endoscopic resection with adjuvant medical therapy (30%) and endoscopic dilation (50%). These findings provide valuable information for healthcare providers and patients in making treatment decisions.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Jin An, Jae-Won Song
Summary: Severe subglottic stenosis in GPA requires active intratracheal intervention, surgery, and systemic immunosuppressive therapy for treatment.
MEDICINA-LITHUANIA
(2021)
Article
Medicine, Research & Experimental
Alexandra D'Oto, Hayley Baker, Ted Mau, Lesley F. Childs, Kathleen M. Tibbetts
Summary: This study compared characteristics of patients with idiopathic subglottic stenosis (iSGS) who were older than 65 years to those who were younger. The results showed that both groups had similar comorbidities and disease courses. However, older patients had higher rates of tobacco use and type 2 diabetes mellitus (T2DM), which may be related to altered wound healing in this age group.
Review
Otorhinolaryngology
Ashjan Almuhanna, Ayshah Almahboob, Ahmed Alhussien, Reem Aljurayyed, Ahmed Alammar
Summary: Management of subglottic stenosis in GPA patients requires a multidisciplinary approach involving endoscopic and open transcervical surgeries, along with medical treatment to stabilize the active disease and enhance postoperative success rates.
ENT-EAR NOSE & THROAT JOURNAL
(2021)
Article
Medicine, Research & Experimental
Gregory R. Dion, Julian S. De la Chapa, Whitney Bettenhausen, Laura M. Dominguez, C. Blake Simpson
Summary: In this study, patients with autoimmune SGS were found to have a higher likelihood of developing PGS compared to idiopathic counterparts. Counseling for this progression may be necessary based on the findings.
Article
Respiratory System
Zeqin Fan, Lihui Zhang, Li Wei, Xiaoxian Huang, Mei Yang, Xiqian Xing
Summary: By studying the microbiome and metabolome of patients with tracheal stenosis, researchers found that carnitine levels were significantly lower in tracheal scar tissue compared to scar-free tissue, suggesting it could be a potential target for the prevention and treatment of iatrogenic tracheal stenosis in the future.
BMC PULMONARY MEDICINE
(2023)
Article
Critical Care Medicine
Jennifer Catano, Yurdagul Uzunhan, Romain Paule, Jeremie Dion, Alexis Regent, Paul Legendre, Francois Gonin, Emmanuel Martinod, Pascal Cohen, Xavier Puechal, Veronique Le Guern, Luc Mouthon, Andre Coste, Christine Lorut, Candice La Croix, Sophie Perie, Benjamin Terrier
Summary: This study found that GPA and RP are the two main inflammatory diseases presenting with SGS/TS. GPA-related stenoses are mostly subglottic and circumferential, whereas RP-related stenoses are mostly tracheal, anterior, and calcified with a frequent extension to bronchi.
Article
Otorhinolaryngology
Michael Eggerstedt, Young Jae Kim, Ethan M. Ritz, Tirth R. Patel, Shannon M. Theis, Inna A. Husain
Summary: The study identified an impact on voice-related quality of life in patients with subglottic stenosis, with breathlessness during speech potentially more significant than inability to speak.
AMERICAN JOURNAL OF OTOLARYNGOLOGY
(2021)
Article
Respiratory System
Chad A. Newton, Kiran Batra, Jose Torrealba, Julia Kozlitina, Craig S. Glazer, Carlos Aravena, Keith Meyer, Ganesh Raghu, Harold R. Collard, Christine Kim Garcia
EUROPEAN RESPIRATORY JOURNAL
(2016)
Article
Respiratory System
Robert Brownell, Teng Moua, Travis S. Henry, Brett M. Elicker, Darin White, Eric Vittinghoff, Kirk D. Jones, Anatoly Urisman, Carlos Aravena, Kerri A. Johannson, Jeffrey A. Golden, Talmadge E. King, Paul J. Wolters, Harold R. Collard, Brett Ley
Meeting Abstract
Critical Care Medicine
Carlos Aravena Leon, Hanine Inaty, Adrianna Urbas, Keith Grafmeyer, Michael Machuzak, Sonali Sethi, Thomas Gildea
Meeting Abstract
Critical Care Medicine
Lucas Rathunde, Cleveland Clinic, Carlos Aravena Leon, Francisco Almeida
Meeting Abstract
Critical Care Medicine
Lucas Rathunde, Carlos Aravena Leon, Francisco Almeida
Article
Respiratory System
Sameer K. Avasarala, Carlos Aravena, Francisco A. Almeida
JOURNAL OF THORACIC DISEASE
(2020)
Article
Cardiac & Cardiovascular Systems
Carlos Aravena, Francisco A. Almeida, Daniel A. Culver, Manuel L. Ribeiro Neto
RESPIRATORY MEDICINE
(2020)
Article
Critical Care Medicine
Gabriela Martinez-Zayas, Francisco A. Almeida, Lonny Yarmus, Daniel Steinfort, Donald R. Lazarus, Michael J. Simoff, Timothy Saettele, Septimiu Murgu, Tarek Dammad, D. Kevin Duong, Lakshmi Mudambi, Joshua J. Filner, Sofia Molina, Carlos Aravena, Jeffrey Thiboutot, Asha Bonney, Adriana M. Rueda, Labib G. Debiane, D. Kyle Hogarth, Harmeet Bedi, Mark Deffebach, Ala-Eddin S. Sagar, Joseph Cicenia, Diana H. Yu, Avi Cohen, Laura Frye, Horiana B. Grosu, Thomas Gildea, David Feller-Kopman, Roberto F. Casal, Michael Machuzak, Muhammad H. Arain, Sonali Sethi, George A. Eapen, Louis Lam, Carlos A. Jimenez, Manuel Ribeiro, Laila Z. Noor, Atul Mehta, Juhee Song, Humberto Choi, Junsheng Ma, Liang Li, David E. Ost
Summary: The HAL and HOMER models demonstrated good discrimination and calibration across multiple centers, with small calibration errors that did not significantly impact their informativeness.
Article
Respiratory System
Carlos Aravena, Jinesh Patel, Abha Goyal, Wissam Jaber, Danai Khemasuwan, Michael Machuzak, Joseph Cicenia, Thomas Gildea, Sonali Sethi, Atul C. Mehta, Francisco A. Almeida
JOURNAL OF BRONCHOLOGY & INTERVENTIONAL PULMONOLOGY
(2020)
Meeting Abstract
Respiratory System
Carlos Aravena Leon, Hanine N. Inaty, Adrianna Urbas, Keith Grafmeyer, Michael S. Machuzak, Sonali Sethi, Thomas R. Gildea
Meeting Abstract
Critical Care Medicine
C. A. Aravena Leon, L. S. Lam, T. R. Gildea
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
C. A. Aravena Leon, Y. Sarda, J. C. Cicenia, T. R. Gildea, M. Machuzak, S. Sethi, A. C. Mehta, M. L. Ribeiro Neto, H. Choi, B. P. Young, P. J. Mazzone, L. S. Lam, F. A. Almeida
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Meeting Abstract
Critical Care Medicine
C. A. Aravena Leon, Y. Sarda, J. Reynolds, J. Brainard, J. C. Cicenia, S. Sethi, T. R. Gildea, M. Machuzak, A. C. Mehta, H. Choi, P. J. Mazzone, B. P. Young, L. S. Lam, M. L. Ribeiro Neto, F. A. Almeida
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2018)
Article
Critical Care Medicine
Julie Morisset, Kerri A. Johannson, Eric Vittinghoff, Carlos Aravena, Brett M. Elicker, Kirk D. Jones, Charlene D. Fell, Helene Manganas, Bruno-Pierre Dube, Paul J. Wolters, Harold R. Collard, Christopher J. Ryerson, Brett Ley