Ganoderma lucidum Immune Modulator Protein rLZ-8 Could Prevent and Reverse Bone Loss in Glucocorticoids-Induced Osteoporosis Rat Model

Osteoimmunology: A Current Update of the Interplay Between Bone and the Immune System

(2020) Christian Guder et al.   Frontiers in Immunology

Treating osteoporosis to prevent fractures: current concepts and future developments

(2019) Mattias Lorentzon   JOURNAL OF INTERNAL MEDICINE

Pro-inflammatory cytokines: cellular and molecular drug targets for glucocorticoid-induced-osteoporosis via osteocyte

(2018) Tiantian Wang et al.   CURRENT DRUG TARGETS

Antitumour, Antimicrobial, Antioxidant and Antiacetylcholinesterase Effect of Ganoderma Lucidum Terpenoids and Polysaccharides: A Review

(2018) Darija Cör et al.   MOLECULES

Therapeutic Mechanisms of Glucocorticoids

(2018) Jolien Vandewalle et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Identifying the “Mushroom of Immortality”: Assessing the Ganoderma Species Composition in Commercial Reishi Products

(2018) Andrew L. Loyd et al.   Frontiers in Microbiology

Glucocorticoid-Induced Osteoporosis

(2018) Lenore Buckley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ganomycin I from Ganoderma lucidum attenuates RANKL-mediated osteoclastogenesis by inhibiting MAPKs and NFATc1

(2018) Phuong Thao Tran et al.   PHYTOMEDICINE

Romosozumab or Alendronate for Fracture Prevention in Women with Osteoporosis

(2017) Kenneth G. Saag et al.   NEW ENGLAND JOURNAL OF MEDICINE

Infections in De Novo Kidney Transplant Recipients Treated With the RANKL Inhibitor Denosumab

(2017) Marco Bonani et al.   TRANSPLANTATION

Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation

(2016) Tung-Yi Lin et al.   CANCER LETTERS

Natural products for treatment of osteoporosis: The effects and mechanisms on promoting osteoblast-mediated bone formation

(2016) Jing An et al.   LIFE SCIENCES

Preclinical Trials for Prevention of Tumor Progression of Hepatocellular Carcinoma by LZ-8 Targeting c-Met Dependent and Independent Pathways

(2015) Jia-Ru Wu et al.   PLoS One

An Immunomodulatory Protein (Ling Zhi-8) from aGanoderma lucidumInduced Acceleration of Wound Healing in Rat Liver Tissues after Monopolar Electrosurgery

(2014) Hao-Jan Lin et al.   Evidence-based Complementary and Alternative Medicine

Glucocorticoid-induced osteoporosis: who to treat with what agent?

(2014) René Rizzoli et al.   Nature Reviews Rheumatology

Reishi Protein LZ-8 Induces FOXP3+Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice

(2013) Hsien-Yeh Hsu et al.   Evidence-based Complementary and Alternative Medicine

The clinical utility of bone marker measurements in osteoporosis

(2013) Gillian Wheater et al.   Journal of Translational Medicine

Ling Zhi-8 mediates p53-dependent growth arrest of lung cancer cells proliferation via the ribosomal protein S7-MDM2-p53 pathway

(2011) Chien-Ting Wu et al.   CARCINOGENESIS

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells

(2011) CHONGYANG LIANG et al.   ONCOLOGY REPORTS

Functional expression of LZ-8, a fungal immunomodulatory protein from Ganoderma lucidium in Pichia pastoris

(2009) Qin Xue et al.   JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY

An immunomodulatory protein, Ling Zhi-8, induced activation and maturation of human monocyte-derived dendritic cells by the NF-κB and MAPK pathways

(2009) Yu-Li Lin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Dosing-time dependent effect of dexamethasone on bone density in rats

(2009) Masaki Takahashi et al.   LIFE SCIENCES

Functions of RANKL/RANK/OPG in bone modeling and remodeling

(2008) Brendan F. Boyce et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Regulation of osteoclastogenesis by ganoderic acid DM isolated from Ganoderma lucidum

(2008) Ichiko Miyamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Crystal structure of LZ-8 from the medicinal fungusGanoderma lucidium

(2008) Liang Huang et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS