Journal
FEBS OPEN BIO
Volume 10, Issue 5, Pages 827-834Publisher
WILEY
DOI: 10.1002/2211-5463.12834
Keywords
apoptosis; diabetes; diabetic nephropathy; endoplasmic reticulum stress; HK-2 cells; pyruvate
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Funding
- Outstanding Clinical Discipline Project of Shanghai Pudong [PWYgy-2018-08]
- Construction of Key Academic Groups in Nephrology in Pudong New Area [PWZxq2017-07]
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Endoplasmic reticulum (ER) stress plays a critical role in the development of diabetic nephropathy (DN). We previously demonstrated that pyruvate (Pyr)-enriched oral rehydration solution improved glucometabolic disorders and ameliorated DN outcome in db/db mice. Here, we investigated the effects of Pyr on high glucose-induced ER stress and apoptosis in HK-2 cells. Our results suggest that high glucose can induce reactive oxygen species production, apoptosis and ER stress in HK-2 cells, and that Pyr treatment can ameliorate these effects and restore the expression of key proteins involved in ER stress. Thus, Pyr may have potential for the development of novel strategies for the prevention and treatment of clinical DN.
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