Review
Genetics & Heredity
Jiao Li, Lingyun Lu, Yi Liu, Xijie Yu
Summary: Bone marrow is a heterogeneous environment containing various cells, with changes in osteoblast and adipocyte numbers being critical factors in bone marrow adipose tissue (BMAT) production. Targeting the formation of BMAT could be a more effective approach in treating osteoporosis than blocking bone-destroying molecules produced by BMAT. Understanding the molecular basis of increased BM adiposity during pathologic bone loss is essential for developing therapeutic strategies.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Review
Endocrinology & Metabolism
Ziru Li, Clifford J. Rosen
Summary: Bone marrow adipose tissue (BMAT) is a significant component of the bone marrow space in healthy adults, but its expansion is associated with aging, obesity, anorexia nervosa, and irradiation. While traditionally viewed as a negative component, recent studies have revealed that BMAT can serve as an energy reservoir and also plays a role in regulating bone formation and hematopoiesis. This review summarizes the unique characteristics of BMAT and provides an updated understanding of its physiological roles based on a newly established mouse model.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yu-Hee Kim, Hyun-Ji Lee, Kyung-Ah Cho, So-Youn Woo, Kyung-Ha Ryu
Summary: This study found that conditioned medium obtained from human tonsil-derived MSCs (T-MSC CM) can inhibit adipocyte differentiation by regulating glucocorticoid signal transduction, thereby reducing obesity. The experiments showed that T-MSC CM can attenuate early-stage adipocyte differentiation and protect mice from the negative effects induced by glucocorticoid treatment. Additionally, T-MSC CM enhances megakaryocyte differentiation and protects blood platelet counts.
Article
Endocrinology & Metabolism
Kerensa M. Beekman, Martine Regenboog, Aart J. Nederveen, Nathalie Bravenboer, Martin den Heijer, Peter H. Bisschop, Carla E. Hollak, Erik M. Akkerman, Mario Maas
Summary: This study aimed to determine region-specific variations and age- and gender-specific differences in bone marrow adipose tissue (BMAT) in healthy subjects. The results showed distinct distribution of BMAT throughout the human skeleton, which was associated with age and gender. Furthermore, the study found that BMAT unsaturation was highest within the axial skeleton compared to the appendicular skeleton.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Rossella Labella, Sarah Little-Letsinger, Viktorjia Avilkina, Rita Sarkis, Michaela Tencerova, Annegreet Vlug, Biagio Palmisano
Summary: The first International Summer School on Bone Marrow Adiposity was organized virtually, bringing together young scientists interested in bone marrow adipose tissue biology and pathology. The school featured keynote lectures, scientific workshops, and motivational and career development lectures, providing a platform for participants to present their research.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Nicole Aaron, Samantha Costa, Clifford J. Rosen, Li Qiang
Summary: BMAT is now recognized as a metabolically active organ that plays versatile roles in endocrine function, hematopoiesis, bone homeostasis, and metabolism. Age-related inflammatory changes associated with BMAT accrual and the downstream effect on endocrine function, energy expenditure, and metabolism are discussed, with potential therapeutic strategies addressed to prevent dysfunction during aging. Further research is needed to fully understand the explicit characterization of BMAT in aging.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Michele Dello Spedale Venti, Biagio Palmisano, Samantha Donsante, Giorgia Farinacci, Flavia Adotti, Ilenia Coletta, Marta Serafini, Alessandro Corsi, Mara Riminucci
Summary: This study analyzed the morphological and immunophenotypic changes of bone marrow adipocytes (BMAds) in different types of bone marrow cancers. The results showed that BMAds were significantly reduced in both bone marrow metastasis and myeloproliferative neoplasia with grade-3 myelofibrosis, along with a decrease in cell diameter and area. Additionally, the expression of certain markers in BMAds differed in these two types of cancers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Michaela Tencerova, Michaela Ferencakova, Moustapha Kassem
Summary: Bone marrow adipose tissue (BMAT) is no longer considered a bystander, but an active organ involved in bone and whole body energy metabolism. It plays unique metabolic roles in regulating bone homeostasis and energy utilization, affecting skeletal stem cell functions.
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Medical Laboratory Technology
Na He, Min Liu, Yue Wu
Summary: Hematopoietic stem cells are the origin of all blood cells, with the ability to self-renew and differentiate. Bone marrow adipocytes play important roles in regulating hematopoiesis, with conflicting effects on the process.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Review
Pharmacology & Pharmacy
Ryan D. R. Brown, Sarah Spiegel
Summary: This article summarizes the evidence that dysregulation of sphingolipid metabolism and serine palmitoyltransferase (SPT) activity is associated with the pathogenesis of obesity. The functions of SPT and ORMDL in obesity and metabolic disease are also discussed. Gaps and limitations in current knowledge are highlighted, along with the need to further understand the role of ORMDL3 in the development of obesity and metabolic disease. The article concludes by emphasizing the importance of advancing research in this field.
PHARMACOLOGY & THERAPEUTICS
(2023)
Review
Endocrinology & Metabolism
Ilona Juchnicka, Mariusz Kuzmicki, Jacek Szamatowicz
Summary: Obesity is a growing global concern, significantly contributing to the development of diseases like type 2 diabetes and cardiovascular disorders. Excessive lipid accumulation in tissues leads to inflammation and metabolic dysfunction.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Cody McGrath, Sarah E. Little-Letsinger, Jeyantt Srinivas Sankaran, Buer Sen, Zhihui Xie, Martin A. Styner, Xiaopeng Zong, Weiqin Chen, Janet Rubin, Eric L. Klett, Rosalind A. Coleman, Maya Styner
Summary: Exercise has positive effects on skeletal health in lipodystrophy, a condition characterized by lack of white adipose tissue. A mouse model with SEIPIN deficiency showed improvements in trabecular bone density through exercise, despite differences in bone marrow adipose tissue between knockout and wild type mice.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Vibha Singhal, Nazanin Hazhir Karzar, Amita Bose, Colleen Buckless, Kathryn E. Ackerman, Miriam A. Bredella, Anne Klibanski, Madhusmita Misra
Summary: In a study of 15 adolescent and young adult females with FHA, 12 months of transdermal estradiol therapy led to a decrease in bone marrow adipose tissue at the lumbar vertebrae and an increase in radial and tibial cortical volumetric bone mineral density, suggesting a positive association between the two.
Article
Endocrinology & Metabolism
Davide Diacinti, Daniele Diacinti, Antonio Iannacone, Jessica Pepe, Luciano Colangelo, Luciano Nieddu, Endi Kripa, Martina Orlandi, Viviana De Martino, Salvatore Minisola, Cristiana Cipriani
Summary: This study found that postmenopausal women with chronic postsurgical hypoparathyroidism have increased bone marrow adipose tissue (BMAT) which is negatively associated with trabecular microarchitecture, using magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (H-1-MRS).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Pharmacology & Pharmacy
Xu Wang, Guanyu Lu, Xuan Liu, Jinhui Li, Fei Zhao, Kefeng Li
Summary: This article systematically reviewed the use of metabolomics to study the treatment of depression with botanical medicine from 2010 to 2019, summarizing potential biomarkers and metabolic pathways associated with herbal treatment for depression. Through a comprehensive evaluation, it provides a new perspective on expanding the application of botanical medicines for the treatment of depression as novel antidepressants and understanding of their pharmacomechanisms.
CURRENT PHARMACEUTICAL DESIGN
(2021)
Letter
Public, Environmental & Occupational Health
Kaimin Li, Yan Wu, Kefeng Li
DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS
(2022)
Article
Psychiatry
Roel J. T. Mocking, Jane C. Naviaux, Kefeng Li, Lin Wang, Jonathan M. Monk, A. Taylor Bright, Caroline A. Figueroa, Aart H. Schene, Henricus G. Ruhe, Johanna Assies, Robert K. Naviaux
Summary: This study identified biochemical markers in the blood of patients with recurrent major depressive disorder (rMDD) through metabolomics analysis, which have potential predictive value in prospectively identifying the patients at greatest risk of recurrence of a depressive episode.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Physiology
Mark Hepokoski, Jing Wang, Kefeng Li, Ying Li, Purva Gupta, Tina Mai, Alex Moshensky, Mona Alotaibi, Laura E. Crotty Alexander, Atul Malhotra, Prabhleen Singh
Summary: Acute kidney injury has been shown to impact lung metabolism and lead to lung injury, with alterations in mitochondrial function and mtDAMPs correlating with these metabolic changes. Mitochondrial function and mtDAMPs are potential therapeutic targets in preventing lung injury due to AKI.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Letter
Multidisciplinary Sciences
Jinping Zheng, Kaiqiang Wang, Yuefei Wang, Kefeng Li
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Haimeng Hu, Yining Lyu, Shihong Li, Zheng Yuan, Chuntao Ye, Zhao Han, Guangwu Lin
Summary: This study found that tinnitus patients have altered functional connections within the DAN and between the DAN and other brain regions compared to healthy controls. The study suggests that regulating the DAN may improve the disturbance and influence of tinnitus.
Review
Psychiatry
Zhiyun Yang, Lingyu Jian, Hui Qiu, Chaoqing Zhang, Song Cheng, Junjun Ji, Ting Li, Yu Wang, Junfeng Li, Kefeng Li
Summary: Efficient communication between distinct brain systems is crucial for brain function, but major depressive disorder (MDD) can damage functional brain networks and lead to cognitive impairment. Changes in the brain's functional connectome have been associated with MDD pathogenesis, and have potential utility in differentiating MDD from other disorders, predicting recurrence and suicide attempts, and evaluating treatment responses. Aberrant brain functional network organization in MDD is linked to dysregulation of neurotransmitter signaling and neuroplasticity, providing insights into the disease's neurobiological mechanisms and antidepressant efficacy.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Lian Duan, Han-Yu Zhang, Min Lv, Han Zhang, Yao Chen, Ting Wang, Yan Li, Yan Wu, Junfeng Li, Kefeng Li
Summary: This study developed a multivariate model using machine learning algorithms to predict post-RAI hypothyroidism. The model showed good performance in both the training and validation sets. A user-friendly nomogram was also established for clinical use.
ENDOCRINE CONNECTIONS
(2022)
Article
Biochemistry & Molecular Biology
Kefeng Li, Martin Schon, Jane C. Naviaux, Jonathan M. Monk, Nikoleta Alchus-Laiferova, Lin Wang, Igor Straka, Peter Matejicka, Peter Valkovic, Jozef Ukropec, Mark A. Tarnopolsky, Robert K. Naviaux, Barbara Ukropcova
Summary: This study used liquid chromatography-tandem mass spectrometry to analyze metabolomics in the cerebrospinal fluid of 19 young healthy adults before and after acute endurance exercise, revealing significant metabolic changes primarily involving purines, pyrimidines, amino acids, fatty acid oxidation, and other pathways. Furthermore, a crucial metabolic communication channel was identified between the brain and body, with over 80% of the changes in the cerebrospinal fluid linked to mitochondrial and metabolic alterations induced by ATP signaling.
Review
Food Science & Technology
Kefeng Li, Henry Hoi Yee Tong, Yuwei Chen, Yizhu Sun, Jing Wang
Summary: Critical illness leads to numerous deaths, especially during the COVID-19 pandemic. Patients with critical illness often suffer from systemic metabolic disorders and malnutrition. The advancement of metabolomics technology has enabled its broader applications in critical care nutrition.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Pediatrics
Kefeng Li, Kerri Bertrand, Jane C. Naviaux, Jonathan M. Monk, Alan Wells, Lin Wang, Sai Sachin Lingampelly, Robert K. Naviaux, Christina Chambers
Summary: The chemical analysis of human milk can predict the risk of neurodevelopmental delay in infants, allowing for early interventions before symptoms appear.
PEDIATRIC RESEARCH
(2023)
Article
Medicine, Research & Experimental
Ningfang Du, Weiquan Shu, Kefeng Li, Yao Deng, Xinxin Xu, Yao Ye, Feng Tang, Renling Mao, Guangwu Lin, Shihong Li, Xuhao Fang
Summary: This study aimed to explore the correlation between Ki-67 LI and ADC parameters and to predict the level of Ki-67 LI noninvasively before surgery using multiple MRI characteristics. The results showed a negative correlation between ADC parameters and Ki-67 LI, and a multivariate logistic regression model combined with peritumoral edema and ADC parameters could improve the prediction ability of Ki-67 LI.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Environmental Sciences
Kefeng Li, Jane C. Naviaux, Sai Sachin Lingampelly, Lin Wang, Jonathan M. Monk, Claire M. Taylor, Clare Ostle, Sonia Batten, Robert K. Naviaux
Summary: The Continuous Plankton Recorder (CPR) Survey is a long-term and extensive marine plankton sampling program. This study investigated the feasibility of using CPR samples to monitor marine pollution trends. The results showed the presence of various pollutants in plankton, with a decrease in their amounts over the past two decades.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Letter
Multidisciplinary Sciences
Jennifer Sills
Article
Oncology
Yu Zheng, Wenjun Huang, Xuelin Zhang, Chen Lu, Caixia Fu, Shihong Li, Guangwu Lin
Summary: The study found that the true diffusion coefficient (D value) from intravoxel incoherent motion (IVIM) was negatively correlated with Ki-67 expression in lung cancer tissues, and performed well in distinguishing high from low proliferation statuses, as well as small cell lung cancer (SCLC) from non-small cell lung cancer (NSCLC).