RSP5 Positively Regulates the Osteogenic Differentiation of Mesenchymal Stem Cells by Activating the K63-Linked Ubiquitination of Akt

SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis

(2019) Guihua Wang et al.   NATURE CELL BIOLOGY

LncRNA SNHG1 modulates p38 MAPK pathway through Nedd4 and thus inhibits osteogenic differentiation of bone marrow mesenchymal stem cells

(2019) Yunpeng Jiang et al.   LIFE SCIENCES

Smurf1 Silencing Using a LNA‐ASOs/Lipid Nanoparticle System to Promote Bone Regeneration

(2019) Patricia García‐García et al.   Stem Cells Translational Medicine

E3-ubiquitin ligase NEDD4 enhances bone formation by removing TGFβ1-induced pSMAD1 in immature osteoblast

(2018) Seon-Ae Jeon et al.   BONE

Suppression of osteogenic differentiation in mesenchymal stem cells from patients with ossification of the posterior longitudinal ligament by a histamine-2-receptor antagonist

(2017) Xizhe Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Role of RHEB in Regulating Differentiation Fate of Mesenchymal Stem Cells for Cartilage and Bone Regeneration

(2017) Sajjad Ashraf et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ubiquitination of ERMES components by the E3 ligase Rsp5 is involved in mitophagy

(2016) Naïma Belgareh-Touzé et al.   Autophagy

Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?

(2016) Q Chen et al.   CELL DEATH AND DIFFERENTIATION

Mechanisms of mesenchymal stem/stromal cell function

(2016) Jeffrey L. Spees et al.   Stem Cell Research & Therapy

Human mesenchymal stem cells - current trends and future prospective

(2015) Imran Ullah et al.   BIOSCIENCE REPORTS

Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts

(2015) Lili Deng et al.   BONE

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

Role of Rsp5 ubiquitin ligase in biogenesis of rRNA, mRNA and tRNA in yeast

(2015) Anna Domanska et al.   RNA Biology

miR-93 promotes TGF-β-induced epithelial-to-mesenchymal transition through downregulation of NEDD4L in lung cancer cells

(2015) Mei-Hua Qu et al.   TUMOR BIOLOGY

Akt enhances Runx2 protein stability by regulating Smurf2 function during osteoblast differentiation

(2014) You Hee Choi et al.   FEBS Journal

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

TRAF4 Is a Critical Molecule for Akt Activation in Lung Cancer

(2013) W. Li et al.   CANCER RESEARCH

NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation

(2013) Jia Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

(2013) Yingying Zhao et al.   eLife

The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis

(2012) Chia-Hsin Chan et al.   CELL

Endogenous Bone Marrow MSCs Are Dynamic, Fate-Restricted Participants in Bone Maintenance and Regeneration

(2012) Dongsu Park et al.   Cell Stem Cell

Activated NF-κB in Bone Marrow Mesenchymal Stem Cells from Systemic Lupus Erythematosus Patients Inhibits Osteogenic Differentiation Through Downregulating Smad Signaling

(2012) Yu Tang et al.   STEM CELLS AND DEVELOPMENT

Yeast Rsp5 ubiquitin ligase affects the actin cytoskeleton in vivo and in vitro

(2011) Joanna Kaminska et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The E3 Ligase TRAF6 Regulates Akt Ubiquitination and Activation

(2009) W.-L. Yang et al.   SCIENCE

Physiological Interaction Between α-Adducin and WNK1-NEDD4L Pathways on Sodium-Related Blood Pressure Regulation

(2008) Paolo Manunta et al.   HYPERTENSION

Oxidative Stress Induces Vascular Calcification through Modulation of the Osteogenic Transcription Factor Runx2 by AKT Signaling

(2008) Chang Hyun Byon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY