Journal
MICROMACHINES
Volume 11, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/mi11050531
Keywords
cancer metastasis; circulating tumor cells; CTC isolation; microdevices
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Funding
- Ministry of Science and Technology, Taiwan [MOST108-2221-E-182-058]
- Chang Gung Memorial Hospital, Linkou, Taiwan [BMRPC05]
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Cancer metastasis is the primary cause of high mortality of cancer patients. Enumeration of circulating tumor cells (CTCs) in the bloodstream is a very important indicator to estimate the therapeutic outcome in various metastatic cancers. The aim of this article is to review recent developments on the CTC isolation technologies in microdevices. Based on the categories of biochemical and biophysical isolation approaches, a literature review and in-depth discussion will be included to provide an overview of this challenging topic. The current excellent developments suggest promising CTC isolation methods in order to establish a precise indicator of the therapeutic outcome of cancer patients.
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