Article
Psychiatry
Rosnadia Suain Bon, Suthahar Ariaratnam, Zanariah Mat Saher, Mariam Mohamad, Fatt Soon Lee
Summary: The study highlighted a high prevalence of cognitive impairment, depression, and anxiety among elderly patients with type 2 diabetes mellitus. Indian ethnicity and completion of secondary or tertiary education were significant factors associated with cognitive impairment. Early detection and treatment of diabetes, as well as addressing associated risk factors, are crucial in preventing cognitive decline.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Su Fen Ang, Serena Low, Tze Pin Ng, Clara S. H. Tan, Keven Ang, Ziliang Lim, Wern Ee Tang, Tavintharan Subramaniam, Chee Fang Sum, Su Chi Lim
Summary: This study evaluated the association between PAX4 R192H variation and cognitive function in Chinese T2DM patients. The results showed that patients carrying this variation had significantly lower attention index scores. This suggests that the ethnic-specific R192H variation is associated with cognitive impairment in Chinese T2DM patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Endocrinology & Metabolism
Andreea Ciudin, Rafael Simo
Summary: The presence of type 2 diabetes can accelerate cognitive impairment. It is recommended to evaluate the cognitive function of diabetes patients over 65 years old annually. However, current screening tests have limitations in identifying mild cognitive impairment. Retinal microperimetry may be a simple and useful tool for screening and monitoring cognitive function in patients with type 2 diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Xin Zhang, Jiajia Xie, Xiong You, Houwu Gong
Summary: This study collects data from T2DM patients and uses machine learning algorithms and graph neural network models to analyze the risk factors and potential drug treatments for T2DM-CI, providing evidence for the prevention and treatment of T2DM-CI.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jung Eun Yoo, Kyungdo Han, Bongseong Kim, Sang-Hyun Park, Seon Mee Kim, Hye Soon Park, Ga Eun Nam
Summary: Regular physical activity is associated with a lower risk of dementia among individuals with new-onset type 2 diabetes, especially for those who engage in continuous regular physical activity.
Article
Geriatrics & Gerontology
Antonietta Canna, Fabrizio Esposito, Gioacchino Tedeschi, Francesca Trojsi, Carla Passaniti, Irene di Meo, Rita Polito, Maria Ida Maiorino, Giuseppe Paolisso, Mario Cirillo, Maria Rosaria Rizzo
Summary: Functional and metabolic neural changes in Type 2 diabetes mellitus (T2DM) can lead to altered neurovascular conditions, as demonstrated by reduced neurovascular coupling in the default mode network (DMN) and increased neurovascular coupling in attention networks. These alterations in neurovascular coupling are associated with reduced visuo-spatial cognitive performances.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Zhigao Xu, Lili Zhao, Lei Yin, Yan Liu, Ying Ren, Guoqiang Yang, Jinlong Wu, Feng Gu, Xuesong Sun, Hui Yang, Taisong Peng, Jinfeng Hu, Xiaogeng Wang, Minghao Pang, Qiong Dai, Guojiang Zhang
Summary: The study aimed to develop an MRI-based machine learning model and found that the LR algorithm performed the best in predicting cognitive dysfunction in patients with type 2 diabetes, showing potential for clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Health Care Sciences & Services
Angel Michael Ortiz-Zuniga, Olga Simo-Servat, Alba Rojano-Toimil, Julia Vazquez-de Sebastian, Carmina Castellano-Tejedor, Cristina Hernandez, Rafael Simo, Andreea Ciudin
Summary: This study investigated the role of retinal microperimetry in the annual follow-up of cognitive function in patients with T2D. It was found that in the MCI group, there was a significant decline in MMSE score after 12 months, while gaze fixation parameters worsened and significantly correlated with the decrease in MMSE scores.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Health Care Sciences & Services
Nabeel Kinattingal, Seema Mehdi, Krishna Undela, Shahid Ud Din Wani, Mansour Almuqbil, Sultan Alshehri, Faiyaz Shakeel, Mohammad T. Imam, Santhepete N. Manjula
Summary: The research aimed to study the prevalence of cognitive impairment in diabetes mellitus patients and emphasized the importance of early detection and treatment. The study examined diabetic and non-diabetic subjects using the Montreal Cognitive Assessment tool and found that diabetic patients had significantly lower cognitive scores. The study suggested a high prevalence of cognitive impairment in the local T2DM population in Mysuru, India, and recommended further research on cognitive function in diabetic patients across different regions and ethnic groups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Medicine, General & Internal
Ting Pan, Xue Zhou, Xuefeng Li, Heran Wang, Meng Meng, Yiran Han, Xin Qian, Chunhai Chen, Xinhua Chen
Summary: This study aimed to conduct a meta-analysis to evaluate the efficacy of acupuncture in treating T2DM with cognitive impairment. The results of the meta-analysis further confirmed the beneficial effects of acupuncture on patients with this condition.
Article
Neurosciences
Agnieszka Bozanic, Pablo Toro, Sebastian Bello-Lepe, Javier Hurtado-Oliva, Christian Beyle, Catalina Valdes, Francesc Formiga
Summary: The aim of this study was to determine the prevalence and risk factors of cognitive impairment (CI) and its association with type 2 diabetes mellitus (T2DM) in individuals aged 65 years and above. The results showed a significant association between T2DM and CI, with age, education, presence of dyslipidemia, and duration of T2DM identified as risk factors. T2DM patients with CI performed worse in multiple cognitive domains, presenting an amnesic multi-domain cognitive profile.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Cell Biology
Haitao Yu, Yanchao Liu, Ting He, Yao Zhang, Jiahua He, Mengzhu Li, Bijun Jiang, Yang Gao, Chongyang Chen, Dan Ke, Jianjun Liu, Benrong He, Xifei Yang, Jian-Zhi Wang
Summary: The analysis of platelet proteomics in T2DM patients with MCI revealed that the increase of optineurin and rGSK-3 beta(T/S9) can efficiently discriminate MCI patients, showing promise for predicting cognitive decline in T2DM patients.
Article
Clinical Neurology
Bin Wang, Ningjian Wang, Ying Sun, Xiao Tan, Jihui Zhang, Yingli Lu
Summary: This study aimed to investigate whether a healthy lifestyle can reduce the risk of dementia among individuals with diabetes. Using data from the UK Biobank cohort, the study found that adherence to a healthy lifestyle factors was associated with a significantly lower risk of dementia among participants with diabetes.
Article
Endocrinology & Metabolism
Xiaofeng Liu, Zhipei Zhao, Dengbin Chen, Zeqin Zhang, Xiaozhen Lin, Zhanbo Shen, Qingwen Lin, Kengna Fan, Qi Wang, Weiqing Zhang, Qishui Ou
Summary: This study revealed alterations in mitochondrial function in peripheral blood mononuclear cells in patients with T2DM-CI and suggested that the combination of SIRT1 and miR-34a-5p could serve as a promising biomarker for early identification of T2DM-CI patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Multidisciplinary Sciences
Yasuhiro Suzuki, Hiroaki Suzuki, Tatsuya Ishikawa, Yasunori Yamada, Shigeru Yatoh, Yoko Sugano, Hitoshi Iwasaki, Motohiro Sekiya, Naoya Yahagi, Yasushi Hada, Hitoshi Shimano
Summary: This study aimed to investigate falls and identify important risk factors for falls in individuals with type 2 diabetes, including non-elderly patients. The findings showed that lower extremity muscle weakness, elevated fasting C-peptide levels, and reduced grip strength were significant risk factors for falls in type 2 diabetes patients. The random forest analysis was able to identify new risk factors for falls beyond logistic regression.
SCIENTIFIC REPORTS
(2022)