Article
Hematology
Andrea Lee Cervi, Darrin Applegate, Scott M. Stevens, Scott C. Woller, Lisa M. Baumann, Kavya Punchhalapalli, Tzu-Fei Wang, Ramon Lecumberri, Kaity Greco, Yuxin Bai, Samantha Bolger, Stephanie Fontyn, Sam Schulman, Gary Foster, James Demetrios Douketis
Summary: This study aimed to determine the type and duration of antithrombotic therapy used in patients with acute lower extremity DVT who received venous stents. The results showed that anticoagulant therapy without concomitant antiplatelet therapy is the most common antithrombotic strategy in these patients, with approximately 29% receiving indefinite treatment.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Multidisciplinary Sciences
Luca Braga, Hashim Ali, Ilaria Secco, Elena Chiavacci, Guilherme Neves, Daniel Goldhill, Rebecca Penn, Jose M. Jimenez-Guardeno, Ana M. Ortega-Prieto, Rossana Bussani, Antonio Cannata, Giorgia Rizzari, Chiara Collesi, Edoardo Schneider, Daniele Arosio, Ajay M. Shah, Wendy S. Barclay, Michael H. Malim, Juan Burrone, Mauro Giacca
Summary: COVID-19 patients' lungs contain infected pneumocytes with abnormal morphology and frequent multinucleation, leading to the formation of syncytia driven by the activation of the SARS-CoV-2 spike protein. The antihelminthic drug niclosamide has shown to effectively inhibit cell fusion, potentially providing a new therapeutic approach for COVID-19 disease pathogenesis.
Article
Critical Care Medicine
James A. Giles, Vamshi K. S. Balasetti, Allyson R. Zazulia
Summary: The safety and efficacy of NOACs for treating CVT are similar to those of VKAs and historical controls, with most patients showing good anticoagulation effects during follow-up, but there are also fewer cases of major bleeding complications.
NEUROCRITICAL CARE
(2021)
Article
Hematology
Hilary Whitworth, Helen Havens Clark, Rebecca A. Hubbard, Char Witmer, Charles E. Leonard, Leslie Raffini
Summary: This study examined the incidence rate of recurrent VTE in pediatric patients with unprovoked VTE, evaluated potential risk factors for recurrence, and described anticoagulation regimens and bleeding in this population. The results showed that age ≥ 12 years and inherited thrombophilia were significantly associated with recurrent VTE. Future research should focus on the efficacy of prolonged anticoagulation for this population.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Medicine, General & Internal
Omri Cohen, Samuela Pegoraro, Walter Ageno
Summary: Cerebral venous thrombosis is a rare but leading cause of stroke in young adults, with diagnosis, treatment, and risk factors similar to other venous thrombosis. Early recognition and timely treatment are crucial.
Article
Medicine, General & Internal
Dongwon Yoon, Han Eol Jeong, Sohee Park, Seng Chan You, Soo-Mee Bang, Ju-Young Shin
Summary: This study investigated the feasibility of using real-world evidence studies to complement randomized controlled trials in patients with venous thromboembolism. The results showed that real-world study populations differed in demographic characteristics compared to trial populations, with RWE populations being older, more female, and having a higher prevalence of active cancer. The emulated estimates for effectiveness outcomes generally showed superior effectiveness of NOACs, while safety outcomes were consistent with corresponding RCTs in most cases.
Article
Clinical Neurology
Shadi Yaghi, Liqi Shu, Ekaterina Bakradze, Setareh Salehi Omran, James A. Giles, Jordan Y. Amar, Nils Henninger, Marwa Elnazeir, Ava L. Liberman, Khadean Moncrieffe, Jenny Lu, Richa Sharma, Yee Cheng, Adeel S. Zubair, Alexis N. Simpkins, Grace T. Li, Justin Chi Kung, Dezaray Perez, Mirjam Heldner, Adrian Scutelnic, David Seiffge, Bernhard Siepen, Aaron Rothstein, Ossama Khazaal, David Do, Sami Al Kasab, Line Abdul Rahman, Eva A. Mistry, Deborah Kerrigan, Hayden Lafever, Thanh N. Nguyen, Piers Klein, Hugo Aparicio, Jennifer Frontera, Lindsey Kuohn, Shashank Agarwal, Christoph Stretz, Narendra Kala, Sleiman El Jamal, Alison Chang, Shawna Cutting, Han Xiao, Adam de Havenon, Varsha Muddasani, Teddy Wu, Duncan Wilson, Amre Nouh, Syed Daniyal Asad, Abid Qureshi, Justin Moore, Pooja Khatri, Yasmin Aziz, Bryce Casteigne, Muhib Khan, Yao Cheng, Brian Mac Grory, Martin Weiss, Dylan Ryan, Maria Cristina Vedovati, Maurizio Paciaroni, James E. Siegler, Scott Kamen, Siyuan Yu, Christopher R. Leon Guerrero, Eugenie Atallah, Gian Marco De Marchis, Alex Brehm, Tolga Dittrich, Marios Psychogios, Ronald Alvarado-Dyer, Tareq Kass-Hout, Shyam Prabhakaran, Tristan Honda, David S. Liebeskind, Karen Furie
Summary: The study compared the effectiveness of DOACs and warfarin in treating CVT, showing similar outcomes in recurrent venous thrombosis, death, and partial/complete recanalization rates between the two groups, but lower risk of major hemorrhage in the DOACs treatment group.
Review
Hematology
Laura Girardi, Tzu-Fei Wang, Walter Ageno, Marc Carrier
Summary: Patients with cancer have a higher risk of developing venous thromboembolism (VTE) due to specific risk factors and thrombotic and hemostatic pathophysiological pathways. Managing cancer-associated VTE can be challenging due to increased risk of recurrent events and bleeding complications. Direct oral anticoagulants have shown effectiveness, safety, and convenience compared to low-molecular-weight heparin in managing cancer-associated VTE. However, there are still unmet needs and potential solutions, such as factor XI inhibitors, to address bleeding risk, drug interactions, and liver dysfunction.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Review
Chemistry, Medicinal
Kaidireyahan Wumaier, Wenqian Li, Jiuwei Cui
Summary: Venous thromboembolism (VTE) in cancer patients is associated with increased morbidity and mortality, decreased quality of life, and higher economic burden. Low molecular weight heparin (LMWHs) has been the standard treatment for cancer-associated VTE, but the introduction of new oral anticoagulants (NOACs) offers another option for some cancer patients with thrombosis. A more comprehensive understanding of drug properties, efficacy and safety, and economic analysis is needed to choose the most appropriate treatment.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Hematology
Dimitrios Rafail Kalaitzopoulos, Anastasios Panagopoulos, Saurabhi Samant, Natasha Ghalib, Jona Kadillari, Angelos Daniilidis, Nicolas Samartzis, Janaki Makadia, Leonidas Palaiodimos, Damianos G. Kokkinidis, Nikolaos Spyrou
Summary: Venous thromboembolism (VTE) in pregnancy is a significant cause of maternal mortality. Differentiating between physiological changes and symptoms of VTE can be challenging, and timely and accurate diagnosis is crucial. Systemic anticoagulation is a key aspect of VTE prevention and therapy.
THROMBOSIS RESEARCH
(2022)
Review
Hematology
Brandon Lui, Benjamin Wee, Jeffrey Lai, Zille Khattak, Anna Kwok, Cynthia Donarelli, Prahlad Ho, Hui Yin Lim
Summary: The study found that the treatment outcomes for VTE improved over time, with reduced rates of thrombotic recurrence and clinically significant bleeding complications in the DOAC era compared to the warfarin era.
THROMBOSIS RESEARCH
(2022)
Article
Hematology
Anne Hege Aamodt, Thor Wakon Skattor
Summary: Cerebral venous thrombosis (CVT) is a rare form of stroke that primarily affects younger individuals, particularly reproductive-age females. Due to its vague clinical and radiological presentation, CVT is often overlooked. Magnetic resonance venography and computed tomography venography can confirm the diagnosis of CVT. Anticoagulation with low-molecular-weight heparin is the main treatment, while endovascular intervention remains controversial. This review provides an overview of the epidemiology, diagnosis, and treatment of CVT in adults, as well as discusses the increased occurrence of CVT in patients with COVID-19 or following COVID-19 vaccination.
SEMINARS IN THROMBOSIS AND HEMOSTASIS
(2022)
Article
Hematology
Marie Giraud, Judith Catella, Lucile Cognet, Helene Helfer, Sandrine Accassat, Celine Chapelle, Patrick Mismetti, Silvy Laporte, Isabelle Mahe, Laurent Bertoletti
Summary: This study aimed to investigate the management of patients diagnosed with acute VTE while receiving antiplatelet treatment. It was found that a portion of patients were discharged with concomitant anticoagulant and antiplatelet therapy, a decision that may be associated with a lower risk of cardiovascular events but increased risk of bleeding.
THROMBOSIS RESEARCH
(2021)
Article
Hematology
Waldemar E. Wysokinski, Damon E. Houghton, Danielle T. Vlazny, Aneel A. Ashrani, David A. Froehling, Patrick S. Kamath, Ryan A. Meverden, David O. Hodge, Lisa G. Peterson, Teresa R. Lang, Robert D. McBane, Ana I. Casanegra
Summary: The outcome of anticoagulation for cancer-associated venous thromboembolism differs depending on the location of the cancer, suggesting the need for tailored anticoagulation strategies.
THROMBOSIS RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Beata Franczyk, Anna Gluba-Brzozka, Janusz Lawinski, Magdalena Rysz-Gorzynska, Jacek Rysz
Summary: VTE, consisting of DVT and PE, is a major cause of cardiovascular disease. Current diagnosis and treatment guidance for VTE are limited, and there is a lack of understanding of the mechanisms and pathways responsible for the occurrence of observed alterations. The application of metabolomics profiling may play a significant role in early diagnosis and management, but more research is needed to fully understand VTE-related metabolic changes.
Article
Medicine, Research & Experimental
Charles P. Hinzman, Meth Jayatilake, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Yubo Zhang, Shivani Bansal, Michael Girgis, Anton Iliuk, Xiao Xu, Jose A. Fernandez, John H. Griffin, Elizabeth A. Ballew, Keith Unger, Marjan Boerma, Meetha Medhora, Amrita K. Cheema
Summary: This study compares and optimizes methods for isolation and analysis of extracellular vesicles (EVs) from small volumes of urine. The size-exclusion chromatography method is found to be the preferred method for EV isolation. Mass spectrometry analysis of EV cargo reveals radiation-induced changes in nucleotide, folate, and lipid metabolism. These findings have important implications for monitoring response to radiotherapy and other molecular phenotyping studies.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Mojca Jensterle, Rok Herman, Andrej Janez, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Massimo Galia, Su-Yen Goh, Sanjay Kalra, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: The article reviews the rationale for glucocorticoid use in COVID-19 and emphasizes the need to be cautious about glucocorticoid-induced adrenal insufficiency. The authors also discuss other mechanisms that may affect HPA axis function and the increased risk and severity of COVID-19 in patients with pre-existing HPA axis disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Ecology
Jennifer L. Goff, Yan Chen, Michael P. Thorgersen, Linh T. Hoang, Farris L. Poole II, Elizabeth G. Szink, Gary Siuzdak, Christopher J. Petzold, Michael W. W. Adams
Summary: Multiple heavy metal contamination is a common global problem that can disrupt microbial biogeochemical cycling. However, there is a lack of studies on the effects of combinations of heavy metals on bacteria. In this study, we assessed the impact of eight metal contaminants on cell processes using a multiomics approach. The combination of metals had unexpected effects on cell physiology, including a disruption of iron homeostasis and decreased activity of important enzymes. This research highlights the need for multi-metal studies to understand the impacts of complex contaminants on microbial systems.
Review
Biochemistry & Molecular Biology
Giuseppe Mainas, Luigi Nibali, Mark Ide, Wael Al Mahmeed, Khalid Al-Rasadi, Kamila Al-Alawi, Maciej Banach, Yajnavalka Banerjee, Antonio Ceriello, Mustafa Cesur, Francesco Cosentino, Alberto Firenze, Massimo Galia, Su-Yen Goh, Andrej Janez, Sanjay Kalra, Nitin Kapoor, Peter Kempler, Nader Lessan, Paulo Lotufo, Nikolaos Papanas, Ali A. Rizvi, Amirhossein Sahebkar, Raul D. Santos, Anca P. Stoian, Peter P. Toth, Vijay Viswanathan, Manfredi Rizzo
Summary: Periodontitis is a disease that leads to the loss of periodontal attachment and bone resorption. COVID-19 is a contagious disease caused by SARS-CoV-2. Investigations have shown a possible relationship between periodontitis and COVID-19, as both conditions can lead to cardiometabolic impairments. This review aims to summarize the existing evidence regarding the link between periodontitis and COVID-19 and their associated complications.
Article
Hematology
Derek S. Sim, Meenal Shukla, Cornell R. Mallari, Jose A. Fernandez, Xiao Xu, Doug Schneider, Maxine Bauzon, Terry W. Hermiston, Laurent O. Mosnier
Summary: Activated protein C (APC) is a multifunctional coagulation protease with anticoagulant, antiinflammatory, and cytoprotective activities. Through selective modulation of APC activities, therapeutics can be developed for pathologies associated with these mechanisms. Identification of nanobodies that selectively recognize APC has provided insights into the diversity of APC functions and their potential therapeutic applications. LP11, in particular, has been found to selectively modulate APC anticoagulation and PAR1 cleavage, suggesting its potential in promoting hemostasis and cytoprotection in bleeding disorders.
Article
Hematology
Steven P. Grover, Vanthana Bharathi, Jens J. Posma, John H. Griffin, Joseph S. Palumbo, Nigel Mackman, Silvio Antoniak
Summary: The chemotherapeutic drug doxorubicin is cardiotoxic and can cause irreversible heart failure. In addition, it induces the activation of coagulation. Thrombin-mediated activation of protease-activated receptor 1 (PAR1) has been found to contribute to doxorubicin-induced cardiac injury.
Article
Biology
Shivani Bansal, Sunil Bansal, Brian L. Fish, Yaoxiang Li, Xiao Xu, Jose A. Fernandez, John H. Griffin, Heather A. Himburg, Marjan Boerma, Meetha Medhora, Amrita K. Cheema
Summary: The purpose of this study was to investigate longitudinal changes in urinary metabolites after IR exposure and explore the potential alleviation of radiation toxicities through the administration of recombinant APC. Female adult WAG/RijCmcr rats were irradiated and urine samples were collected for LC-MS metabolomics analysis. Different forms of APC were administered to sub-cohorts of rats and the results showed that radiation induced significant changes in urinary profiles, and treatment with rat wildtype-APC or rat 3K3A-APC could alleviate radiation-induced metabolic alterations to some extent.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yaoxiang Li, Shivani Bansal, Vijayalakshmi Sridharan, Sunil Bansal, Meth M. Jayatilake, Jose A. Fernandez, John H. Griffin, Marjan Boerma, Amrita K. Cheema
Summary: In this study, the researchers aimed to identify urinary metabolites that can indicate radiation-induced cardiac damage. They analyzed previously collected urine samples and found that radiation caused disturbances in various metabolic pathways, with wild-type mice showing more prominent effects than APCHi mice. By combining genotype and sex, the researchers identified a urinary biomarker panel that can predict heart dysfunction. It is important to note that this study did not use live mice but focused on analyzing previously collected urine samples.
Article
Biochemistry & Molecular Biology
Naseer A. Kutchy, Amelia Palermo, Rong Ma, Zhong Li, Alexandria Ulanov, Shannon Callen, Gary Siuzdak, Sabita Roy, Shilpa Buch, Guoku Hu
Summary: Morphine administration causes distinct metabolic changes, with acute and chronic use leading to different plasma metabolite concentrations. The alterations in metabolites are linked to the development of tolerance to morphine's analgesic effects. The study also identified metabolites that were differentially affected by acute versus chronic morphine use, suggesting that metabolic changes may be mitigated by prolonged exposure to the drug.
Article
Health Care Sciences & Services
Farah Otaki, Mandana Gholami, Iman Fawad, Anjum Akbar, Yajnavalka Banerjee
Summary: This study aims to develop and evaluate a problem-solving assessment as an instructional tool for a biochemistry course in a medical program. The results will provide evidence for the application of this assessment in achieving competency goals and fostering self-directed learning, which can be beneficial to other medical educators in similar contexts.
JMIR RESEARCH PROTOCOLS
(2023)
Letter
Biochemical Research Methods
Erin S. Baker, Corey Hoang, Winnie Uritboonthai, Heino M. Heyman, Brian Pratt, Michael MacCoss, Brendan MacLean, Robert Plumb, Aries Aisporna, Gary Siuzdak
Editorial Material
Endocrinology & Metabolism
Gary Siuzdak
Summary: Recent advances in mass spectrometry imaging, specifically the development of nano secondary ion mass spectrometry, have made subcellular quantitative analysis a reality, allowing for absolute quantification at the organelle level.
Article
Health Care Sciences & Services
Rajashree Patnaik, Shirin Jannati, Bala Mohan Sivani, Manfredi Rizzo, Nerissa Naidoo, Yajnavalka Banerjee
Summary: This study developed a novel protocol for generating chondrocytes from bone marrow-derived mesenchymal stem cells (BMSCs) in a 3D culture system, which has significant implications for cartilage biology research and the discovery of potential therapeutic interventions.
JMIR RESEARCH PROTOCOLS
(2023)
Letter
Hematology
Swati Sharma, Lauryn T. Ursery, Vanthana Bharathi, Stephen D. Miles, Willie A. Williams, Aymen Z. Elzawam, Clare M. Schmedes, Grant J. Egnatz, Jose A. Fernandez, Joseph S. Palumbo, John H. Grif, Nigel Mackman, Silvio Antoniak
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
