Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2020.00284
Keywords
SARS-CoV-2; asymptomatic infections; coinfection; COVID-19; Mycoplasma pneumonia
Categories
Funding
- National Natural Science Foundation of China [81902066, 81730061, 81471942]
- Natural Science Foundation of Hubei Provincial Department of Education [Q20192105, Q20192104]
- Hubei Provincial Natural Science Foundation [2018CFB185, 2018CFB093]
- COVID-19 Epidemic Emergency Research Foundation [2020XGFYZR07, 2020XGFYZR08]
- Cultivating Project for Young Scholar at Hubei University of Medicine [2017QDJZR08, 2016QDJZR03]
- National Undergraduate Training Program for Innovation and Entrepreneurship [201913249002]
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To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R-0) under containment strategies was 1.81, and asymptomatic SARS-CoV-2 carriers were contagious with a transmission rate of 10.7%. Among the 176 patients, 53 were admitted to the Renmin Hospital of Hubei University of Medicine. The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with Mycoplasma pneumoniae, and COVID-19 patients coinfected with M. pneumoniae had a higher percentage of monocytes (P < 0.0044) and a lower neutrophils percentage (P < 0.0264). Therefore, it is important to assess the transmissibility of infected asymptomatic individuals for SARS-CoV-2 transmission; moreover, clinicians should be alert to the high incidence of co-infection with M. pneumoniae in COVID-19 patients.
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