Single-molecule functional anatomy of endogenous HER2-HER3 heterodimers

Profiling of protein–protein interactions via single-molecule techniques predicts the dependence of cancers on growth-factor receptors

(2018) Hong-Won Lee et al.   Nature Biomedical Engineering

EGF and NRG induce phosphorylation of HER3/ERBB3 by EGFR using distinct oligomeric mechanisms

(2017) Bettina van Lengerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Overcoming resistance to HER2 inhibitors through state-specific kinase binding

(2016) Chris J Novotny et al.   Nature Chemical Biology

AZD9291 inEGFR-mutant advanced non-small-cell lung cancer patients

(2015) Jordi Remon et al.   Future Oncology

Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor

(2015) Erika Kovacs et al.   MOLECULAR AND CELLULAR BIOLOGY

Discovery of a Potent and Selective EGFR Inhibitor (AZD9291) of Both Sensitizing and T790M Resistance Mutations That Spares the Wild Type Form of the Receptor

(2014) M. Raymond V. Finlay et al.   JOURNAL OF MEDICINAL CHEMISTRY

The EGFR Family: Not So Prototypical Receptor Tyrosine Kinases

(2014) M. A. Lemmon et al.   Cold Spring Harbor Perspectives in Biology

Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor

(2013) Nicholas F. Endres et al.   CELL

Real-time single-molecule coimmunoprecipitation of weak protein-protein interactions

(2013) Hong-Won Lee et al.   Nature Protocols

Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics

(2013) Hong-Won Lee et al.   Nature Communications

HER3 Is Required for HER2-Induced Preneoplastic Changes to the Breast Epithelium and Tumor Formation

(2012) D. B. Vaught et al.   CANCER RESEARCH

A New Class of Amphiphiles Bearing Rigid Hydrophobic Groups for Solubilization and Stabilization of Membrane Proteins

(2012) Pil Seok Chae et al.   CHEMISTRY-A EUROPEAN JOURNAL

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors

(2012) Timothy R. Wilson et al.   NATURE

Comprehensive Binary Interaction Mapping of SH2 Domains via Fluorescence Polarization Reveals Novel Functional Diversification of ErbB Receptors

(2012) Ronald J. Hause et al.   PLoS One

Functional isolation of activated and unilaterally phosphorylated heterodimers of ERBB2 and ERBB3 as scaffolds in ligand-dependent signaling

(2012) Q. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-molecule approach to immunoprecipitated protein complexes: insights into miRNA uridylation

(2011) Kyu-Hyeon Yeom et al.   EMBO REPORTS

Probing cellular protein complexes using single-molecule pull-down

(2011) Ankur Jain et al.   NATURE

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Basis for Negative Cooperativity in Growth Factor Binding to an EGF Receptor

(2010) Diego Alvarado et al.   CELL

Spatial control of EGF receptor activation by reversible dimerization on living cells

(2010) Inhee Chung et al.   NATURE

In Vitro Enzymatic Characterization of Near Full Length EGFR in Activated and Inhibited States

(2009) Chen Qiu et al.   BIOCHEMISTRY

Ligand-Independent HER2/HER3/PI3K Complex Is Disrupted by Trastuzumab and Is Effectively Inhibited by the PI3K Inhibitor GDC-0941

(2009) Teemu T. Junttila et al.   CANCER CELL

Mechanism for Activation of the EGF Receptor Catalytic Domain by the Juxtamembrane Segment

(2009) Natalia Jura et al.   CELL

Her4 and Her2/neu Tyrosine Kinase Domains Dimerize and Activate in a Reconstitutedin VitroSystem

(2009) John Monsey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extracting Kinetics Information from Single-Molecule Fluorescence Resonance Energy Transfer Data Using Hidden Markov Models

(2009) Tae-Hee Lee   JOURNAL OF PHYSICAL CHEMISTRY B

The Juxtamembrane Region of the EGF Receptor Functions as an Activation Domain

(2009) Monica Red Brewer et al.   MOLECULAR CELL

Functional and Structural Stability of the Epidermal Growth Factor Receptor in Detergent Micelles and Phospholipid Nanodiscs†

(2008) Li-Zhi Mi et al.   BIOCHEMISTRY

A Central Role for HER3 in HER2-Amplified Breast Cancer: Implications for Targeted Therapy

(2008) S. T. Lee-Hoeflich et al.   CANCER RESEARCH