Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

Metabolic and skeletal homeostasis are maintained in full locus GPRC6A knockout mice

(2019) Christinna V. Jørgensen et al.   Scientific Reports

Biomolecular regulation, composition and nanoarchitecture of bone mineral

(2018) Atharva A. Poundarik et al.   Scientific Reports

Glucose Tolerance Tests and Osteocalcin Responses in Healthy People

(2018) Jakob Starup-Linde et al.   Frontiers in Endocrinology

Synchronous disruption of anisotropic arrangement of the osteocyte network and collagen/apatite in melanoma bone metastasis

(2017) Aiko Sekita et al.   JOURNAL OF STRUCTURAL BIOLOGY

Crosstalk Between Bone and Fat Tissue: Associations Between Vitamin D, Osteocalcin, Adipokines, and Markers of Glucose Metabolism Among Adolescents

(2017) Kelly Virecoulon Giudici et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Unloading-Induced Degradation of the Anisotropic Arrangement of Collagen/Apatite in Rat Femurs

(2016) Jun Wang et al.   CALCIFIED TISSUE INTERNATIONAL

Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication

(2016) Gerard Karsenty et al.   CELL

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

(2016) Laura J. Lambert et al.   Disease Models & Mechanisms

Evidence for Osteocalcin Binding and Activation of GPRC6A in β-Cells

(2016) Min Pi et al.   ENDOCRINOLOGY

Murine GPRC6A Mediates Cellular Responses to L-Amino Acids, but Not Osteocalcin Variants

(2016) Patricia Rueda et al.   PLoS One

Refinement of collagen–mineral interaction: A possible role for osteocalcin in apatite crystal nucleation, growth and development

(2015) Ling Chen et al.   BONE

Osteocalcin Promotes  -Cell Proliferation During Development and Adulthood Through Gprc6a

(2013) J. Wei et al.   DIABETES

Reduced Serum Concentrations of Carboxylated and Undercarboxylated Osteocalcin Are Associated With Risk of Developing Type 2 Diabetes Mellitus in a High Cardiovascular Risk Population: A Nested Case-Control Study

(2013) Andrés Díaz-López et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The l-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in l-arginine-induced insulin release

(2012) Sanela Smajilovic et al.   AMINO ACIDS

GPRC6A Mediates the Effects ofl-Arginine on Insulin Secretion in Mouse Pancreatic Islets

(2012) Min Pi et al.   ENDOCRINOLOGY

Reduced serum osteocalcin concentrations are associated with type 2 diabetes mellitus and the metabolic syndrome components in postmenopausal women: the crosstalk between bone and energy metabolism

(2012) Ali Movahed et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Degree of biological apatitec-axis orientation rather than bone mineral density controls mechanical function in bone regenerated using recombinant bone morphogenetic protein-2

(2012) Takuya Ishimoto et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Significant inverse relationship between serum undercarboxylated osteocalcin and glycemic control in maintenance hemodialysis patients

(2012) S. Okuno et al.   OSTEOPOROSIS INTERNATIONAL

Osteocyte Network; a Negative Regulatory System for Bone Mass Augmented by the Induction of Rankl in Osteoblasts and Sost in Osteocytes at Unloading

(2012) Takeshi Moriishi et al.   PLoS One

Undercarboxylated osteocalcin does not correlate with insulin resistance as assessed by euglycemic hyperinsulinemic clamp technique in patients with type 2 diabetes mellitus

(2012) Katsuhito Mori et al.   Diabetology & Metabolic Syndrome

Effects of Bone Matrix Proteins on Fracture and Fragility in Osteoporosis

(2012) Grażyna E. Sroga et al.   Current Osteoporosis Reports

Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis

(2011) Yuying Wang et al.   BONE

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

GPRC6A mediates responses to osteocalcin in β-cells in vitro and pancreas in vivo

(2011) Min Pi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study

(2011) M. Iki et al.   OSTEOPOROSIS INTERNATIONAL

Raman Assessment of Bone Quality

(2010) Michael D. Morris et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Quantitative polarized Raman spectroscopy in highly turbid bone tissue

(2010) Mekhala Raghavan et al.   JOURNAL OF BIOMEDICAL OPTICS

How Does Bone Sialoprotein Promote the Nucleation of Hydroxyapatite? A Molecular Dynamics Study Using Model Peptides of Different Conformations

(2010) Yang Yang et al.   LANGMUIR

Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus

(2010) I. Kanazawa et al.   OSTEOPOROSIS INTERNATIONAL

γ-Carboxylation of osteocalcin and insulin resistance in older men and women

(2009) M Kyla Shea et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Bone Mineral Density, Osteocalcin, and Bone-specific Alkaline Phosphatase in Patients with Insulin-dependent Diabetes Mellitus

(2009) Franco Lumachi et al.   Annals of the New York Academy of Sciences

The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects

(2009) You-Cheol Hwang et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Serum osteocalcin concentrations in relation to glucose and lipid metabolism in Chinese individuals

(2009) Mi Zhou et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Magnitude and Rate of Bone Loss in Ovariectomized Mice Differs Among Inbred Strains as Determined by Longitudinal In vivo Micro-Computed Tomography

(2008) Josh Klinck et al.   CALCIFIED TISSUE INTERNATIONAL

Relationship between osteocalcin and glucose metabolism in postmenopausal women

(2008) Jee-Aee Im et al.   CLINICA CHIMICA ACTA

Plasma Osteocalcin Is Inversely Related to Fat Mass and Plasma Glucose in Elderly Swedish Men

(2008) Jenny M Kindblom et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Association between Serum Osteocalcin and Markers of Metabolic Phenotype

(2008) Anastassios G. Pittas et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serum Osteocalcin Level Is Associated with Glucose Metabolism and Atherosclerosis Parameters in Type 2 Diabetes Mellitus

(2008) Ippei Kanazawa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training

(2008) Jose Manuel Fernández-Real et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions

(2008) Petrine Wellendorph et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Effect of osteocalcin deficiency on the nanomechanics and chemistry of mouse bones

(2008) N.B. Kavukcuoglu et al.   Journal of the Mechanical Behavior of Biomedical Materials

GPRC6A Null Mice Exhibit Osteopenia, Feminization and Metabolic Syndrome

(2008) Min Pi et al.   PLoS One