Journal
JOURNAL OF PARKINSONS DISEASE
Volume 10, Issue 3, Pages 855-873Publisher
IOS PRESS
DOI: 10.3233/JPD-202006
Keywords
Autonomic nervous system; gait; natural history; observational study; Parkinson's disease; phenotype; real-world data; sleep; smartphone; social behavior
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Funding
- National Institute of Neurological Disorders and Stroke of the National Institutes of Health [P50NS108676]
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Phenotype is the set of observable traits of an organism or condition. While advances in genetics, imaging, and molecular biology have improved our understanding of the underlying biology of Parkinson's disease (PD), clinical pheno-typing of PD still relies primarily on history and physical examination. These subjective, episodic, categorical assessments are valuable for diagnosis and care but have left gaps in our understanding of the PD phenotype. Sensors can provide objective, continuous, real-world data about the PD clinical phenotype, increase our knowledge of its pathology, enhance evaluation of therapies, and ultimately, improve patient care. In this paper, we explore the concept of deep phenotyping-the comprehensive assessment of a condition using multiple clinical, biological, genetic, imaging, and sensor-based tools-for PD. We discuss the rationale for, outline current approaches to, identify benefits and limitations of, and consider future directions for deep clinical phenotyping.
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