Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Oncology
Srideshikan Sargur Madabushi, Raghda Fouda, Hemendra Ghimire, Amr M. H. Abdelhamid, Ji Eun Lim, Paresh Vishwasrao, Stacy Kiven, Jamison Brooks, Darren Zuro, Joseph Rosenthal, Chandan Guha, Kalpna Gupta, Susanta K. Hui
Summary: Sickle cell disease is a serious global health problem and the only curative option is hematopoietic stem cell transplant. Reduced-intensity total body radiation is currently used as a conditioning regimen and targeted marrow irradiation is a novel technique that can protect organs and effectively treat some patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Mary Eapen, Ruta Brazauskas, David A. Williams, Mark C. Walters, Andrew St Martin, Benjamin L. Jacobs, Joseph H. Antin, Kira Bona, Sonali Chaudhury, Victoria H. Coleman-Cowger, Nancy L. DiFronzo, Erica B. Esrick, Joshua J. Field, Courtney D. Fitzhugh, Julie Kanter, Neena Kapoor, Donald B. Kohn, Lakshmanan Krishnamurti, Wendy B. London, Michael A. Pulsipher, Sohel Talib, Alexis A. Thompson, Edmund K. Waller, Ted Wun, Mary M. Horowitz
Summary: This study investigates the incidence and risk factors for secondary neoplasm after transplantation for sickle cell disease. The results show that the 10-year incidence of leukemia/MDS was 1.7% and of any secondary neoplasm was 2.4%. Low-intensity regimens were associated with higher risks for leukemia/MDS or any secondary neoplasm compared with more intense regimens.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Hematology
Sherif M. Badawy, Usman Beg, Robert Liem, Sonali Chaudhury, Alexis A. Thompson
Summary: There is increasing interest in curative therapies for patients with sickle cell disease (SCD) and thalassemia, including hematopoietic stem cell transplant (HSCT) and gene therapy. Research shows that HSCT has a positive impact on HRQOL, with potential for improvement in HRQOL outcomes following gene therapy in patients with SCD and thalassemia.
Review
Hematology
Lydia H. Pecker, Deva Sharma, Alecia Nero, Michael J. Paidas, Russell E. Ware, Andra H. James, Kim Smith-Whitley
Summary: There is an urgent need to address the reproductive health of girls and women with sickle cell disease (SCD). Existing literature is mostly descriptive and lacks high-quality interventional studies. An expert panel convened in 2020 identified significant limitations to clinical care and prominent barriers to research and care for women with SCD.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Article
Biophysics
Gaurav Kharya, Atish Bakane, Shirali Agarwal, Archana Rauthan
Summary: The T-cell-replete haploidentical transplant with PTIS, augmented John Hopkins conditioning and plerixafor-based mobilization is a safe and effective way of treating patients suffering from SCD, with minimal or no risk of graft failure and acceptable GvHD rates.
BONE MARROW TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Robert Sheppard Nickel, Jacqueline Y. Maher, Michael H. Hsieh, Meghan F. Davis, Matthew M. Hsieh, Lydia H. Pecker
Summary: Curative therapy for sickle cell disease can impair future fertility and the fertility outcomes are influenced by factors such as pre-transplant ovarian reserve, semen analysis parameters, and the conditioning regimen. Patients should be offered fertility preservation before treatment and receive longitudinal post-HSCT fertility care.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Chemistry, Medicinal
Annamaria Aprile, Silvia Sighinolfi, Laura Raggi, Giuliana Ferrari
Summary: Research in the last decade has shown multiple alterations of the BM niche in beta-thalassemia and sickle cell disease, emphasizing the importance of understanding the interaction between HSC biology and the BM microenvironment in improving clinical outcomes of transplantation.
Article
Oncology
Emily Riehm Meier, Allistair A. Abraham, Alex Ngwube, Isaac A. Janson, Gregory M. T. Guilcher, John Horan, Kimberly A. Kasow
Summary: This study assessed providers' perceptions on MSD HSCT for children with varying SCD severity, finding that physicians focused on SCD and HSCT are more likely to refer patients for HSCT, especially in cases where children have not been hospitalized or have suboptimal treatment outcomes. Additionally, a significantly higher proportion of providers would refer a child with beta-thalassemia major for HSCT compared to asymptomatic children with specific hemoglobin types, suggesting differing referral practices based on disease severity.
PEDIATRIC BLOOD & CANCER
(2021)
Review
Medicine, General & Internal
Nishka Bhalla, Anjali Bhargav, Sandeep Kumar Yadav, Aloukick Kumar Singh
Summary: Sickle cell disease (SCD) has been mentioned in the literature for a century, and advancements in understanding its molecular basis have provided various treatment options. Allogeneic hematopoietic stem cell transplantation (HSCT) is currently the only available option, although limitations such as donor availability and risks of complications exist. This review discusses different approaches to allogeneic HSCT for curing SCD, and highlights the potential of using megadose T-cell-depleted bone marrow in combination with donor-derived CD8 veto T cells under reduced intensity conditioning (RIC).
FRONTIERS IN MEDICINE
(2023)
Article
Biophysics
Tami D. John, Brian Friend, Khaled Yassine, Ghadir Sasa, Saleh Bhar, Baheyeldin Salem, Bilal Omer, John Craddock, Erin Doherty, Caridad Martinez, Helen E. Heslop, Robert A. Krance, Kathryn Leung
Summary: Alemtuzumab used in myeloablative conditioning of matched related donor transplant for sickle cell disease shows promising results with low rejection and GVHD rates, high event-free survival, and low incidence of acute and chronic GVHD. Further evaluation in older patients and with unrelated donors is warranted to confirm its potential effectiveness.
BONE MARROW TRANSPLANTATION
(2021)
Article
Immunology
Gustavo de Sousa Arantes Ferreira, Clara Antunes Ferreira, Andre Luis Conde Watanabe, Natalia Carvalho Trevizoli, Maria Clara Borges Murta, Ana Virginia Ferreira Figueira, Carolina de Fatima Couto
Summary: Sickle cell anemia is a common hemoglobin disorder that can be treated with hematopoietic stem cell transplantation. However, patients may experience chronic liver disease as a complication, with iron overload being an important factor. Additionally, solid organ transplantation after allogeneic hematopoietic cell transplantation is rare.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Medicine, General & Internal
Oyku Durmus, Ozay Gokoz, Emine Arzu Saglam, Eser Lay Ergun, Duygu Gulseren
Summary: A 60-year-old man with a history of IgA nephropathy and renal allograft developed a painless, rapidly growing, haemorrhagic pink nodule on his thigh. Excisional biopsy confirmed the diagnosis of Merkel cell carcinoma (MCC) with no distant metastases. Bone marrow biopsy revealed metastasis of MCC after 10 months due to pancytopenia and disease progression shown on FDG PET/CT. Dermatologists and oncologists should be aware of the potential involvement of bone marrow in organ transplant recipients, and regular follow-up with blood counts, FDG PET/CT, and bone marrow biopsy when necessary is recommended.
Article
Hematology
Monica L. Hulbert, Melanie E. Fields, Kristin P. Guilliams, Priyesha Bijlani, Shalini Shenoy, Slim Fellah, Alison S. Towerman, Michael M. Binkley, Robert C. McKinstry, Joshua S. Shimony, Yasheng Chen, Cihat Eldeniz, Dustin K. Ragan, Katie Vo, Hongyu An, Jin-Moo Lee, Andria L. Ford
Summary: This study investigated the effect of hematopoietic stem cell transplant (HSCT) on cerebral hemodynamics in children with sickle cell disease (SCD). It found that HSCT normalized cerebral blood flow and oxygen extraction fraction in SCD children, reducing the risk of strokes.
Review
Medicine, General & Internal
Chiara Visintini, Irene Mansutti, Alvisa Palese
Summary: This systematic review aims to summarize the available evidence on medication adherence in patients receiving HSCT, including prevalence rates, risk factors, interventions, and outcomes associated with medication non-adherence.
Article
Environmental Sciences
Evrosina I. Isaac, Urmila Sivagnanalingam, Andrea R. Meisman, Crista Wetherington Donewar, Linda J. Ewing, Ernest R. Katz, Anna C. Muriel, Jennifer M. Rohan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
Article
Psychology, Developmental
Adi Ziv, Jennifer M. O'Donnell, Nana Ofei-Tenkorang, Andrea R. Meisman, Janet K. Nash, Laurie P. Mitan, Mark DiFrancesco, Mekibib Altaye, Catherine M. Gordon
JOURNAL OF ADOLESCENT HEALTH
(2020)
Article
Environmental Sciences
Caitlin J. Cain, Andrea R. Meisman, Kirstin Drucker, Evrosina I. Isaac, Tanvi Verma, Jordyn Griffin, Jennifer M. Rohan
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2020)
News Item
Education, Scientific Disciplines
Francis J. Real, Andrea Meisman, Brittany L. Rosen
Article
Pediatrics
Francis J. Real, Monica Whitehead, Nicholas J. Ollberding, Brittany L. Rosen, Andrea Meisman, Lori E. Crosby, Melissa D. Klein, Rachel Herbst
Summary: This study examined the effectiveness of a training curriculum using virtual reality (VR) simulations to improve residents' skills in behavioral health anticipatory guidance (BHAG) and motivational interviewing (MI). The results showed that VR training enhanced residents' BHAG skills, open-ended questioning, and MI adherence behaviors compared to the control group. Further research will focus on assessing the generalizability of the VR curriculum and exploring opportunities to enhance its scalability through artificial intelligence.
ACADEMIC PEDIATRICS
(2023)
Article
Public, Environmental & Occupational Health
Francis J. Real, Nicholas J. Ollberding, Andrea R. Meisman, Dominick J. DeBlasio, Mary Beth Pero, David Davis, Bradley Cruse, Melissa D. Klein, Jessica A. Kahn, Brittany L. Rosen
Summary: This study developed a virtual reality-based intervention called VICTORI, which allowed physicians to practice recommendation behaviors for HPV vaccination. Compared to the control group that only used a smartphone application, the intervention group, who completed the application and VR simulations, showed a significant increase in HPV vaccine initiation rates among patients in the 6 months after the study. These findings suggest that virtual reality training can effectively improve physicians' recommendation behaviors and promote vaccine uptake.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2022)
Article
Endocrinology & Metabolism
Nat Nasomyont, Andrea R. Meisman, Kirsten Ecklund, Sridhar Vajapeyam, Kim M. Cecil, Jean A. Tkach, Mekibib Altaye, Sarah D. Corathers, Lee Ann Conard, Heidi J. Kalkwarf, Lawrence M. Dolan, Catherine M. Gordon
Summary: Pubertal suppression with GnRH agonists may negatively affect BMAT and bone mass acquisition in TGNC youth.
JOURNAL OF CLINICAL DENSITOMETRY
(2022)
Article
Pediatrics
Rachel Herbst, Tiffany Rybak, Andrea Meisman, Monica Whitehead, Brittany Rosen, Lori E. Crosby, Melissa D. Klein, Francis J. Real
Summary: This study explored the usability of a VR-based behavioral health anticipatory guidance curriculum for pediatric residents. Results showed that residents reported high levels of immersion, cognitive involvement, and spatial presence. The VR technology not only expanded residents' knowledge and skills in behavioral health anticipatory guidance, but also provided a safe and immersive environment for practice and learning new skills.
JMIR PEDIATRICS AND PARENTING
(2021)