Article
Biochemistry & Molecular Biology
Kai Kou, Shuxuan Li, Wei Qiu, Zhongqi Fan, Mingqian Li, Guoyue Lv
Summary: Hepatic stellate cells (HSCs) upregulate hypoxia inducible factor 1 alpha (HIF-1 alpha) expression in response to fibrosis-induced hypoxia. Increased expression of alpha-SMA, HIF-1 alpha, and IL-6 was observed in liver fibrotic tissues, along with their colocalization. HIF-1 alpha induced IL-6 secretion in activated HSCs by binding to the HRE region in the IL6 promoter. HIF-1 alpha also promoted IL-17A expression and secretion in HSCs, mediated by IL-17A-enriched supernatant.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
You-Wu Dai, Xin-Jiang Lu, Rui Jiang, Jian-Fei Lu, Guan-Jun Yang, Jiong Chen
Summary: The study revealed that HIF-1 alpha in ayu plays a crucial role in the immune system by regulating cytokine expression, enhancing phagocytic and bactericidal activities, and improving host defenses.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY
(2021)
Article
Cell Biology
Nashwa Amin, Shijia Chen, Qiannan Ren, Xiaoning Tan, Benson O. A. Botchway, Zhiying Hu, Fengpei Chen, Shan Ye, Xiaoxue Du, Zuobing Chen, Marong Fang
Summary: The study found that in a focal cerebral ischemia mouse model, the activator of hypoxia-inducible factor 1 significantly increased IL-10 levels while decreasing inflammatory factors iNOS, TNF-alpha, and NF-kB levels, exerting an anti-inflammatory role to alleviate brain damage. Additionally, astrocytic activation was inhibited, and hypoxia-inducible factor 1 induction alleviated neuronal soma damage and cell death.
Review
Oncology
Kenneth N. Huynh, Sriram Rao, Bradley Roth, Theodore Bryan, Dayantha M. Fernando, Farshid Dayyani, David Imagawa, Nadine Abi-Jaoudeh
Summary: Hypoxia-inducible factor 1 alpha (HIF-1a) is a transcription factor that regulates the cellular response to hypoxia and is upregulated in all types of solid tumor. Hepatocellular carcinoma (HCC) is a highly vascular and hypoxic tumor, and treatments like TACE and TAE can exacerbate hypoxia in HCC. Hypoxia-activated prodrugs (HAPs) have potential as a targeted treatment for hypoxic HCC, but more research is needed to understand their effects in combination with embolization.
Article
Ophthalmology
Bing X. Ross, Lin Jia, Dejuan Kong, Tiantian Wang, Jingyu Yao, Heather M. Hager, Steven F. Abcouwer, David N. Zacks
Summary: The study aimed to determine the necessity of HIF-1a on PR cell survival after RD. The findings suggest that rod-derived HIF-1a plays a key role in promoting PR cell survival.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Gastroenterology & Hepatology
Pan Cao, Qian Chen, Chun-Xia Shi, Lu-Wen Wang, Zuo-Jiong Gong
Summary: This study suggests that Sirt1 may protect against acute liver failure by inducing the deacetylation of HIF-1 alpha to reduce ROS.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Gastroenterology & Hepatology
Zhao-Yang Wang, Yu Liu, Shi-Peng Li, Jian-Jun Li, Zhen Zhang, Xue-Chun Xiao, Yang Ou, Hang Wang, Jin-Zhen Cai, Shuang Yang
Summary: This study identified IL-1ra as a key regulator in hepatic ischemia-reperfusion injury (IRI), with its expression being regulated by HIF-1 alpha. Ischemic preconditioning was shown to protect the liver from IRI through the HIF-1 alpha-IL-1ra pathway.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, Research & Experimental
Tripti Singh, Pallabi Banerjee, Uditi, Sarita Kumari, Anita Chopra, Nagendra Singh, Imteyaz Qamar
Summary: Regucalcin regulates intracellular Ca2+ homeostasis and intracellular signaling pathways. Its expression in hypoxia is upregulated by HIF-1α through direct binding to the HRE binding motifs within the Regucalcin promoter.
Article
Cell Biology
Quanrongzi Wang, Xinya Zhu, Zijian Li, Min Feng, Xisheng Liu
Summary: Macrophages play a crucial role in liver fibrogenesis by producing cytokines that activate HSCs. ATF6 signaling significantly influences cytokine expression and liver fibrogenesis after acute liver injury.
CELLULAR IMMUNOLOGY
(2021)
Article
Immunology
Sebastian F. Zenk, Sebastian Hauck, Daniel Mayer, Mark Grieshober, Steffen Stenger
Summary: Hypoxia-inducible factor (HIF) plays a crucial role in regulating cellular metabolism in response to a low oxygen environment, and stabilizing HIF can enhance host antimicrobial activity against tuberculosis. Inhibition of prolyl-hydroxylases by Molidustat further induces specific immune effectors, reducing the proliferation of intracellular mycobacteria in human macrophages. These findings suggest that HIFs may be promising targets for host-directed therapy against infectious diseases like tuberculosis caused by intracellular bacteria.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cell Biology
Beatrice Foglia, Erica Novo, Francesca Protopapa, Marina Maggiora, Claudia Bocca, Stefania Cannito, Maurizio Parola
Summary: Liver fibrosis is a potentially reversible pathophysiological event characterized by excess deposition of extracellular matrix components, which is primarily driven by activated myofibroblasts and other hepatic cell populations involved in chronic liver disease progression. The emerging pathogenic role of hypoxia, hypoxia-inducible factors, and related mediators in the fibrogenic progression of chronic liver diseases is a key focus of research.
Article
Biotechnology & Applied Microbiology
Xin Tang, Cheng Chang, Michelle Hao, Mei Chen, David T. Woodley, Axel H. Schonthal, Wei Li
Summary: HIF-1 and Hsp90 play critical roles in spermatogenesis and tumorigenesis, with Hsp90 alpha affecting the levels of HIF-1 alpha in testis, and Hsp90 beta providing protection for signaling molecules responsible for cellular homeostasis.
CANCER GENE THERAPY
(2021)
Review
Immunology
Qianyan He, Yinzhong Ma, Jie Liu, Dianhui Zhang, Jiaxin Ren, Ruoyu Zhao, JunLei Chang, Zhen-Ni Guo, Yi Yang
Summary: Ischemic stroke, caused by inadequate cerebrovascular blood and oxygen supply, poses a significant global health burden. HIF-1α, a key regulator of oxygen homeostasis, plays a critical role in various aspects of stroke pathophysiology and is an important target for potential therapeutic interventions. Further research into the differential regulation of HIF-1α in different cell types during ischemic stroke is crucial for understanding the disease mechanism and identifying novel treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Orthopedics
Zeina Salloum, Eric A. Lehoux, Mary-Ellen Harper, Isabelle Catelas
Summary: Implant wear and corrosion can cause adverse tissue reactions leading to implant failure, with the products of wear and corrosion being a major clinical concern. Co2+ and Cr3+ from CoCrMo-based implants have been shown to induce a proinflammatory response in macrophages. The metabolic shift induced by Co2+ towards glycolysis, along with increased oxidative stress, plays a key role in the inflammatory response of macrophages.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Annett Eitner, Sylvia Mueller, Christian Koenig, Arne Wilharm, Rebecca Raab, Gunther O. Hofmann, Thomas Kamradt, Hans-Georg Schaible
Summary: IL-1 beta induces NO release and mitochondrial dysfunction, and both can be prevented by inhibiting iNOS with L-NIL. Additionally, enhancing cAMP or inhibiting AMPK can reduce the effects of IL-1 beta, preventing NO release and mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Caroline Laheurte, Evan Seffar, Eleonore Gravelin, Julie Lecuelle, Adeline Renaudin, Laura Boullerot, Marine Malfroy, Amelie Marguier, Benoit Lecoester, Beatrice Gaugler, Philippe Saas, Caroline Truntzer, Francois Ghiringhelli, Olivier Adotevi
Summary: Plasmacytoid dendritic cells (pDCs) in non-small cell lung cancer patients have been shown to have an ambivalent role in cancer immunity. Higher levels of circulating pDCs are associated with improved overall survival (OS) in NSCLC, especially in early-stage patients, and a high pDC signature in the tumor microenvironment predicts better efficacy of immune checkpoint inhibitors in these patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Immunology
Maxime Nguyen, Laure Stiel, Adrien Guilloteau, Pierre-Alain Bahr, David Masson, Charles Thomas, Mathieu Blot, Julien Guy, Cecile Fontaine, Bastien Durand, Belaid Bouhemad, Pierre-Gregoire Guinot
Summary: Cardiac surgery with cardiopulmonary bypass activates sterile inflammation, leading to post-operative morbidity. This study explores the use of cell population data from automated flow cytometry devices to monitor immune cell activation in these patients, providing a potential tool for predicting outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Yasmin El Mahi, Alexis Varin, Mathieu Vetter, Ludivine Dal Zuffo, Loic Mazzeo, Jean-Paul Pais De Barros, Francois Aubin, Philippe Saas, Irene Gallais Serezal
Summary: The relapses of psoriasis are related to T cells that reside in the skin, with the fatty acid intake capacity of tissue-resident memory T cells playing a crucial role in their function. The composition of fatty acids in the skin is linked to the functions of epidermal T cells and may affect the severity of psoriasis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Immunology
Maxime Samson, Coraline Genet, Marc Corbera-Bellalta, Helene Greigert, Georgina Espigol-Frigole, Claire Gerard, Claudie Cladiere, Roser Alba-Rovira, Marion Ciudad, Pierre-Henry Gabrielle, Catherine Creuzot-Garcher, Georges Tarris, Laurent Martin, Philippe Saas, Sylvain Audia, Bernard Bonnotte, Maria C. Cid
Summary: This study evaluated the effect of Human Monocyte-derived Suppressor Cells (HuMoSC) on inflammation and vascular remodeling in Giant Cell Arteritis (GCA) treatment. The results showed that HuMoSCs or their supernatant could decrease vascular inflammation and remodeling, which may address the unmet need in GCA treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Eleonora Sosa Cuevas, Philippe Saas, Caroline Aspord
Summary: Immunotherapies using immune checkpoint blockers have shown clinical success in melanoma, but some patients still relapse or do not respond. Dendritic cells (DCs) play a key role in immune responses and their understanding is important for developing effective immunotherapies. This review provides an overview of DC diversity, their role in melanoma pathophysiology and clinical outcomes, tumor-induced DC subversion mechanisms, and DC-based therapeutic developments.
Article
Immunology
Victor Bosteels, Sandra Marechal, Clint De Nolf, Sofie Rennen, Jonathan Maelfait, Simon J. Tavernier, Jessica Vetters, Evelien Van De Velde, Farzaneh Fayazpour, Kim Deswarte, Alexander Lamoot, Julie Van Duyse, Liesbet Martens, Cedric Bosteels, Ria Roelandt, Annelies Emmaneel, Sofie Van Gassen, Louis Boon, Gert Van Isterdael, Isabelle Guillas, Niels Vandamme, Doris Hoeglinger, Bruno G. De Geest, Wilfried Le Goff, Yvan Saeys, Kodi S. Ravichandran, Bart N. Lambrecht, Sophie Janssens
Summary: Dendritic cells mature in different ways depending on the context, either in an immunogenic or tolerogenic manner. Engulfment of apoptotic cells or cholesterol-rich lipid nanoparticles leads to the homeostatic maturation of type 1 conventional DCs (cDC1s) through the activation of the liver X receptor (LXR) pathway. On the other hand, engagement of TLR3 to mimic viral infection represses the LXR pathway, delaying cellular cholesterol efflux and inducing genes associated with T cell-mediated immunity.
SCIENCE IMMUNOLOGY
(2023)
Article
Engineering, Biomedical
Daniel Luz, Tomaz Bisneto, Thiago Lima, Mano Mathew, Flavio Araujo
Summary: Breast cancer is a tumor that results from abnormal cell proliferation in breast tissue. Early diagnosis is crucial for patient survival, but it requires extensive histopathological analysis, which can be time-consuming. Computational methods such as digital image processing and deep learning can help quickly identify tumor malignancies in scanned images and speed up the diagnostic process. This study proposes a methodology for automatic diagnosis of malignant breast lesions based on bioinspired texture features and deep learning features. Evaluation of color normalization methods showed improved accuracy, with the proposed method achieving 92.9% accuracy using a random forest classifier. These findings suggest that the combination of bioinspired texture features and deep features outperforms individual techniques and can be used in computer-aided detection systems.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Cardiac & Cardiovascular Systems
Louise Menegaut, Aline Laubriet, Valentin Crespy, Damien Leleu, Thomas Pilot, Kevin Van Dongen, Jean-Paul Pais de Barros, Thomas Gautier, Jean-Michel Petit, Charles Thomas, Maxime Nguyen, Eric Steinmetz, David Masson
Summary: This study aimed to investigate the increase of 2-AA-LPC in carotid plaques from T2DM and control patients and explore its association with plaque vulnerability and biomarkers altered during diabetes. The results showed that 2-AA-LPC was significantly enriched in plaques from diabetic patients and correlated with inflammatory markers within the plaques. This highlights the involvement of local inflammation, arachidonic acid metabolism, and diabetes in the pathogenesis of atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Immunology
Emilie Gaiffe, Mathilde Colladant, Maxime Desmaret, Jamal Bamoulid, Franck Leroux, Caroline Laheurte, Sophie Brouard, Magali Giral, Philippe Saas, Cecile Courivaud, Nicolas Degauque, Didier Ducloux
Summary: Unsupervised hierarchical clustering analysis was performed on pre-transplant immunological phenotype in 1113 renal transplant recipients, identifying three immune profiles correlated with clinical phenotypes. The memory immune cluster was associated with older age and diabetes, while the activated immune cluster was associated with younger age and previous exposure to CMV. Both were associated with an increased risk of acute rejection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Emilie Gaiffe, Dewi Vernerey, Laurent Bardiaux, Franck Leroux, Aurelia Meurisse, Jamal Bamoulid, Cecile Courivaud, Philippe Saas, Marc Hazzan, Pierre Tiberghien, Didier Ducloux
Summary: A longer storage duration of red blood cells (RBC) was associated with a decreased risk of transplant failure among patients who received kidney transplants and RBC transfusions. Preferential use of RBC with longer storage duration might improve kidney graft survival following transplant and transfusion.
Article
Engineering, Biomedical
Pablo de Abreu Vieira, Luis Vogado, Lucas Lopes, Ricardo Ricardo, Pedro Santos Neto, Mano Joseph Mathew, Deborah Magalhaes, Romuere Silva
Summary: The lumbosacral exam provides detailed spine radiographs and enables various computer-aided diagnoses. A deep learning-based CAD system was developed to detect lumbosacral anomalies, achieving promising results with accuracy, kappa, and F1-Score. An ensemble classification combining frontal and lateral images was also developed, issuing alerts with a low False Discovery Rate and allowing specialists to assist in decision-making.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Computer Science, Artificial Intelligence
Edson Damasceno Carvalho, Otilio Paulo da Silva Neto, Mano Joseph Mathew, Antonio Oseas de Carvalho Filho
Summary: Predicting the response of breast tumors to treatment is crucial for patients undergoing neoadjuvant chemotherapy. This study presents a new methodology that effectively predicts tumor response using dynamic contrast magnetic resonance imaging (DCE-MRI) and achieved high accuracy in various steps such as tumor segmentation and classification of malignancy. The proposed methodology proves to be efficient and can be integrated into a support system for breast cancer treatment.
EXPERT SYSTEMS WITH APPLICATIONS
(2023)
Article
Rheumatology
Sophie Hecquet, Perle Totoson, Helene Martin, Marie-Paule Algros, Philippe Saas, Jean-Paul Pais-de-Barros, Alban Atchon, Benoit Valot, Didier Hocquet, Maude Tournier, Clement Prati, Daniel Wendling, Celine Demougeot, Frank Verhoeven
Summary: Intestinal inflammation and alterations of the intestinal barrier are not the consequence of joint damage, and intestinal changes occurred in the absence of bacterial translocation.
ARTHRITIS RESEARCH & THERAPY
(2023)
Article
Immunology
Camille Niveau, Eleonora Sosa Cuevas, Benoit Roubinet, Mylene Pezet, Michel Thepaut, Stephane Mouret, Julie Charles, Franck Fieschi, Ludovic Landemarre, Laurence Chaperot, Philippe Saas, Caroline Aspord
Summary: Dendritic cell subsets play a crucial role in shaping anti-tumour immunity. The study found that melanoma tumour cells display aberrant glycan motifs which can be sensed by dendritic cells through specific receptors. This interaction may lead to abnormal immune responses. The study suggests that targeting the glycan/receptor axis could be a promising strategy for improving cancer immunotherapy.
Article
Critical Care Medicine
Claire Chaignat, Laurent Lagrost, Karena Moretto, Jean-Paul Pais de Barros, Hadrien Winiszewski, Jacques Grober, Philippe Saas, Gael Piton
Summary: The aim of this study was to investigate the correlation between plasma citrulline levels and plasma lipopolysaccharide (LPS) concentration, as well as the impact of sepsis on gut function in critically ill patients. The results showed no correlation between plasma citrulline concentration and plasma LPS concentration or activity. However, septic patients had significantly lower plasma citrulline levels. Additionally, abdominal sepsis was associated with higher plasma LPS activity compared to extra-abdominal sepsis.
JOURNAL OF CRITICAL CARE
(2024)
