Review
Oncology
Piotr Peczek, Monika Gajda, Kacper Rutkowski, Marta Fudalej, Andrzej Deptala, Anna M. Badowska-Kozakiewicz
Summary: Cancer cells can escape immune destruction and exploit tumor-associated inflammation, leading to tumor progression. Understanding the roles of immune cell populations and reshaping tumor-associated inflammation can improve cancer therapy efficacy. Increased tumor-associated inflammation can overcome cancer-derived immunosuppression, while specific methods like cancer vaccines and chimeric antigen receptor T cells can enhance the immune system's ability to destroy cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Chunli Wang, Lingzu Kong, Seokmin Kim, Sunyoung Lee, Sechan Oh, Seona Jo, Inhwan Jang, Tae-Don Kim
Summary: This review summarizes the roles of IL-7 and IL-7R alpha in immunity and cancer, and discusses their recent advances and potential as immunotherapy tools.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Dou Yin, Sheng Chen, Jun Liu
Summary: Autoimmune neurologic diseases are a new type of immune-mediated diseases with diverse clinical manifestations. Sleep disturbances, including excessive daytime sleep, RBD, and narcolepsy, have been reported to have a significant negative impact on the quality of life in patients with autoimmune neurologic diseases. These sleep disturbances can be either initial symptoms or persistent throughout the disease course, and they are believed to be associated with underlying pathophysiological mechanisms.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Oncology
Antonio Avallone, Sabrina Bimonte, Claudia Cardone, Macro Cascella, Arturo Cuomo
Summary: Chemotherapy-induced peripheral neuropathy is a challenging adverse effect of chemotherapy that significantly affects patients' quality of life. Despite various treatment approaches, there is currently no standardized treatment. Therefore, finding effective therapies is necessary.
ANTICANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Chinenye R. Dike, Qin (Kiki) Sun, Lola Rahib, Megan Golden, Maisam Abu-El-Haija
Summary: This study aimed to determine the prevalence of symptoms and diagnoses reported by patients with extra pancreatic manifestation of pancreatitis. The results showed that adults reported more symptoms and diagnoses compared to children, including nighttime sweats, bloating or cramping, greasy stools, feeling cold, and GERD.
Review
Endocrinology & Metabolism
Shaofang Zhu, Jiabin Yu, Youliang Wu, Ju Peng, Xuemin Xie, Xiaojing Zhang, Haitao Xie, Lisen Sui
Summary: Seizures are a common symptom of autoimmune encephalitis, often accompanied by other clinical features. Different antibodies have different effects on patients and their responses to treatment. Understanding the pathogenic mechanisms of autoantibodies can help in the diagnosis and treatment of different types of autoimmune encephalitis.
NEUROIMMUNOMODULATION
(2022)
Review
Pharmacology & Pharmacy
Stavros P. Papadakos, Konstantinos Arvanitakis, Ioanna E. Stergiou, Christos Vallilas, Stavros Sougioultzis, Georgios Germanidis, Stamatios Theocharis
Summary: This study discusses the significance of chronic inflammation in the development of hepatocellular carcinoma (HCC) and explores the role of extracellular vesicles (EVs) as well as the Toll-like receptor 4 (TLR4) signaling pathway in chronic liver disease and HCC. Furthermore, it delves into the therapeutic potential of EVs in modulating the TLR4 pathway for the treatment of HCC.
Review
Biochemistry & Molecular Biology
Chiara Cilibrasi, Panagiotis Papanastasopoulos, Mark Samuels, Georgios Giamas
Summary: Breast cancer immunotherapy, as an active field of research over the past 50 years, has shown great potential in improving survival rates for patients. Researchers are exploring how breast cancer evades immune destruction and developing new treatment options such as cell therapies, vaccines, checkpoint inhibitors, and oncolytic viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Wojciech Lubon, Malgorzata Lubon, Przemyslaw Kotyla, Ewa Mrukwa-Kominek
Summary: Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with up to one-third of patients experiencing various ocular manifestations. Ocular findings may be the initial signs of the disease and can lead to severe complications and vision loss. Early diagnosis and proper management are crucial, requiring collaboration among specialists. Adequate preparation of ophthalmologists can help differentiate SLE complications from other eye disorders. New therapies for SLE show promise, but their ocular side effects are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Junpeng Zhao, Liming Li, Huiqi Yin, Xiwei Feng, Qianjin Lu
Summary: Immune checkpoints, such as PD1 and CTLA-4, play a crucial role in immune cell regulation to prevent autoimmunity and maintain tolerance. Targeting these checkpoints has shown significant potential in cancer therapy. TIGIT, as another immune inhibitory receptor, may also be a promising target for both autoimmune diseases and cancers.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Stephanie H. Chen, Pamela K. O'Dea, Bahareh Sianati, David R. Benavides
Summary: Autoimmune encephalitis (AE) often presents with seizures that are refractory to anti-seizure medications (ASM). A subset of patients with AE, called autoimmune-associated epilepsy (AAE), continue to have refractory epilepsy for years. Optimal treatment for AAE is still unknown, and the efficacy of neuromodulation and immunotherapy in managing AE has not been well established.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maryam Masoumi, Nader Hashemi, Fatemeh Moadab, Mojtaba Didehdar, Rahim Farahani, Hossein Khorramdelazad, Amirhossein Sahebkar, Thomas P. Johnston, Jafar Karami
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint damage. RA patients face systemic complications and progressive disability, resulting in significant socio-economic costs. Current RA biomarkers have limited success in predicting, diagnosing, and monitoring the disease. Studies suggest that dysregulated immunometabolism could be targeted for RA treatment.
CURRENT MEDICINAL CHEMISTRY
(2023)
Review
Immunology
Christina Lamers, Carla Johanna Pluss, Daniel Ricklin
Summary: The beta(2)-integrin receptor family, particularly complement receptor 3 (CR3), plays a significant role in various physiological functions and has a wide range of ligand selectivity with close to 100 structurally unrelated ligands reported. CR3's versatility is reflected in its functions including removal of invaders and cell debris, tolerance induction, synaptic pruning, and involvement in autoimmune and chronic inflammatory pathologies. However, the limited molecular understanding of CR3's interactions with ligands hinders drug development efforts targeting immune modulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jun Liu, Hui Zhang, Yanhong Su, Baojun Zhang
Summary: Dysregulation of auto-reactive T cells and autoantibody-producing B cells, as well as excessive inflammation, contribute to the development of autoimmune diseases. Pattern recognition receptors (PRRs) play a significant role in autoimmune diseases and targeting these receptors may be a viable therapeutic strategy. This review summarizes the advancements in PRRs signaling pathways, their association with autoimmune diseases, and the application of inhibitors targeting PRRs.
CELL AND BIOSCIENCE
(2022)
Review
Immunology
Isabelle Paggioli, Jeremy Moss
Summary: Alopecia Areata is an autoimmune disease that results in rapid hair loss and is associated with psychological disorders and decreased quality of life. There are currently no effective treatments, but JAK inhibitors may be a promising option.
JOURNAL OF AUTOIMMUNITY
(2022)