Introducing Glycolinkers for the Functionalization of Cytotoxic Drugs and Applications in Antibody-Drug Conjugation Chemistry

New developments for antibody-drug conjugate-based therapeutic approaches

(2016) Bart ECG de Goeij et al.   CURRENT OPINION IN IMMUNOLOGY

Field Guide to Challenges and Opportunities in Antibody–Drug Conjugates for Chemists

(2015) Mallory R. Gordon et al.   BIOCONJUGATE CHEMISTRY

Antibody-drug conjugates as novel anti-cancer chemotherapeutics

(2015) C. Peters et al.   BIOSCIENCE REPORTS

Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index

(2015) Robert P Lyon et al.   NATURE BIOTECHNOLOGY

Preparation of Well-Defined Antibody-Drug Conjugates through Glycan Remodeling and Strain-Promoted Azide-Alkyne Cycloadditions

(2014) Xiuru Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Statistical Modeling of the Drug Load Distribution on Trastuzumab Emtansine (Kadcyla), a Lysine-Linked Antibody Drug Conjugate

(2014) Michael T. Kim et al.   BIOCONJUGATE CHEMISTRY

Trastuzumab emtansine: mechanisms of action and drug resistance

(2014) Mark Barok et al.   BREAST CANCER RESEARCH

Cyclodextrin mediated polymer coupling via thiol–maleimide conjugation: facile access to functionalizable hydrogels

(2014) M. Arslan et al.   RSC Advances

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Antibody–drug conjugates: current status and future directions

(2013) Heidi L. Perez et al.   DRUG DISCOVERY TODAY

Maturing antibody–drug conjugate pipeline hits 30

(2013) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Antibody–drug conjugates

(2013) Rachel S. Zolot et al.   NATURE REVIEWS DRUG DISCOVERY

Antibody-Drug Conjugates in Cancer Therapy

(2012) Eric L. Sievers et al.   Annual Review of Medicine

Carbohydrate microarrays

(2012) Sungjin Park et al.   CHEMICAL SOCIETY REVIEWS

The discovery and development of brentuximab vedotin for use in relapsed Hodgkin lymphoma and systemic anaplastic large cell lymphoma

(2012) Peter D Senter et al.   NATURE BIOTECHNOLOGY

Trastuzumab Emtansine for HER2-Positive Advanced Breast Cancer

(2012) Sunil Verma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthesis of site-specific antibody-drug conjugates using unnatural amino acids

(2012) J. Y. Axup et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Mechanism to Mouse: A Tale of Two Bioorthogonal Reactions

(2011) Ellen M. Sletten et al.   ACCOUNTS OF CHEMICAL RESEARCH

Bioconjugation via azide–Staudinger ligation: an overview

(2011) Christine I. Schilling et al.   CHEMICAL SOCIETY REVIEWS

Trastuzumab Emtansine: A Unique Antibody-Drug Conjugate in Development for Human Epidermal Growth Factor Receptor 2-Positive Cancer

(2011) P. M. LoRusso et al.   CLINICAL CANCER RESEARCH

Efficient Synthesis of DNA Conjugates by Strain-Promoted Azide-Cyclooctyne Cycloaddition in the Solid Phase

(2011) Ishwar Singh et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis and Evaluation of Hydrophilic Linkers for Antibody–Maytansinoid Conjugates

(2011) Robert Y. Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thiol-Ene Click Chemistry

(2010) Charles E. Hoyle et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Azide: A Unique Dipole for Metal-Free Bioorthogonal Ligations

(2010) Marjoke F. Debets et al.   CHEMBIOCHEM

Brentuximab Vedotin (SGN-35) for Relapsed CD30-Positive Lymphomas

(2010) Anas Younes et al.   NEW ENGLAND JOURNAL OF MEDICINE

Chemically-selective surface glyco-functionalization of liposomes through Staudinger ligation

(2009) Hailong Zhang et al.   CHEMICAL COMMUNICATIONS

High-efficiency labeling of sialylated glycoproteins on living cells

(2009) Ying Zeng et al.   NATURE METHODS

Rapid Oxime and Hydrazone Ligations with Aromatic Aldehydes for Biomolecular Labeling

(2008) Anouk Dirksen et al.   BIOCONJUGATE CHEMISTRY

Preparation of Poly(ethylene glycol) Protected Nanoparticles with Variable Bioconjugate Ligand Density

(2008) Marian E. Gindy et al.   BIOMACROMOLECULES

Antibody-Drug Conjugates for Cancer Therapy

(2008) Paul J. Carter et al.   CANCER JOURNAL

Carbohydrate microarrays as powerful tools in studies of carbohydrate-mediated biological processes

(2008) Sungjin Park et al.   CHEMICAL COMMUNICATIONS

Carbohydrate arrays as tools for research and diagnostics

(2008) Tim Horlacher et al.   CHEMICAL SOCIETY REVIEWS

Imaging Epidermal Growth Factor Receptor Expression In vivo: Pharmacokinetic and Biodistribution Characterization of a Bioconjugated Quantum Dot Nanoprobe

(2008) P. Diagaradjane et al.   CLINICAL CANCER RESEARCH

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

EGFR Antagonists in Cancer Treatment

(2008) Fortunato Ciardiello et al.   NEW ENGLAND JOURNAL OF MEDICINE