An Enzyme-Directed Imidazoquinoline for Cancer Immunotherapy

Cancer Immunotherapy: Selected Targets and Small-Molecule Modulators

(2016) Hilmar Weinmann   ChemMedChem

Big opportunities for small molecules in immuno-oncology

(2015) Jerry L. Adams et al.   NATURE REVIEWS DRUG DISCOVERY

Annexin V-Directed Enzyme Prodrug Therapy Plus Docetaxel for the Targeted Treatment of Pancreatic Cancer

(2015) Katrin P. Guillen et al.   PANCREAS

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Effective Innate and Adaptive Antimelanoma Immunity through Localized TLR7/8 Activation

(2014) Manisha Singh et al.   JOURNAL OF IMMUNOLOGY

Structure–Activity Relationship Analysis of Imidazoquinolines with Toll-like Receptors 7 and 8 Selectivity and Enhanced Cytokine Induction

(2014) Charles E. Schiaffo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stimulation of Innate Immune Cells by Light-Activated TLR7/8 Agonists

(2014) Keun Ah Ryu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure–activity relationships in Toll-like receptor 7 agonistic 1H-imidazo[4,5-c]pyridines

(2013) Euna Yoo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Immune Checkpoint Inhibitors: Making Immunotherapy a Reality for the Treatment of Lung Cancer

(2013) J. R. Brahmer et al.   Cancer Immunology Research

Antibody-Recruiting Molecules: An Emerging Paradigm for Engaging Immune Function in Treating Human Disease

(2012) Patrick J. McEnaney et al.   ACS Chemical Biology

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

(2012) Barbara Drobits et al.   JOURNAL OF CLINICAL INVESTIGATION

Adjuvant Combination and Antigen Targeting as a Strategy to Induce Polyfunctional and High-Avidity T-Cell Responses against Poorly Immunogenic Tumors

(2011) F. Aranda et al.   CANCER RESEARCH

A Galactosidase-Responsive “Trojan Horse” for the Selective Targeting of Folate Receptor-Positive Tumor Cells

(2011) Mickaël Thomas et al.   ChemMedChem

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

The Innate Immune Response, Clinical Outcomes, and Ex Vivo HCV Antiviral Efficacy of a TLR7 Agonist (PF-4878691)

(2011) M D Fidock et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein

(2011) C G Li et al.   ONCOGENE

The pharmacokinetics of Toll-like receptor agonists and the impact on the immune system

(2011) Abbi L Engel et al.   Expert Review of Clinical Pharmacology

Structure−Activity Relationships in Human Toll-Like Receptor 7-Active Imidazoquinoline Analogues

(2010) Nikunj M. Shukla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeted Enzyme Prodrug Therapies

(2010) N. Schellmann et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

TLR7 and TLR8 as targets in cancer therapy

(2008) M P Schön et al.   ONCOGENE