Article
Chemistry, Analytical
Guy M. Quanrud, Maureen R. Montoya, Liangyong Mei, Mohammad R. Awad, Joseph C. Genereux
Summary: This study developed a quantitative proteomics methodology to identify destabilized proteins based on their binding to the human Hsp40 chaperone DNAJB8. Exposure of HEK293T cells to meta-arsenite increased the affinity of certain proteins to DNAJB8, including the pyruvate dehydrogenase complex E1 subunit and several RNA-binding proteins. The platform can be used to investigate the impact of environmental toxins on cellular proteostasis and identify susceptible proteins.
ANALYTICAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ryuji Owada, Shinichi Mitsui, Kazuhiro Nakamura
Summary: The study revealed that aggregated polyS and polyL peptides can spontaneously enter neuron-like cells and astrocytes, causing cell degeneration, aberrant differentiation, and cell death. Injecting these aggregates into the ventricles of adult mice resulted in behavioral changes, with polyS injection leading to extensive vacuolar degeneration in the brain. This suggests that RAN translation-related proteins containing polyS and polyL have the potential to propagate and exert universal toxicity in recipient cells.
SCIENTIFIC REPORTS
(2022)
Review
Polymer Science
Vladimir Muronetz, Denis Pozdyshev, Pavel Semenyuk
Summary: This review discusses the application of polyelectrolytes, particularly synthetic polyanions and polycations, for immobilizing enzymes and regulating their properties. It focuses on the use of polyelectrolytes to create complex systems such as self-regulated enzyme-polyelectrolyte complexes, artificial chaperones, polyelectrolyte brushes, layer-by-layer immobilization, and others. The review also includes a section on molecular modeling of protein-polyelectrolyte interactions.
Article
Cell Biology
E. F. Elsiena Kuiper, Paola Gallardo, Tessa Bergsma, Muriel Mari, Maiara Kolbe Musskopf, Jeroen Kuipers, Ben N. G. Giepmans, Anton Steen, Harm H. Kampinga, Liesbeth M. Veenhoff, Steven Bergink
Summary: DNAJB6, a molecular chaperone, plays a role in quality control during the biogenesis of nuclear pore complexes, specifically by preventing aggregation of intrinsically disordered FG-Nups.
NATURE CELL BIOLOGY
(2022)
Review
Neurosciences
Stephanie L. Peak, Liam Gracia, Gabriella Lora, Umesh K. Jinwal
Summary: Tau is a microtubule-associated protein involved in promoting microtubule assembly and stability in neuron cells, but its processing can be altered in tauopathies due to gene mutations and post-translational modifications. The chaperone heat shock protein 90 (Hsp90) plays a crucial role in the folding, degradation, and recycling of tau proteins and tau kinases. The study also discusses the impact of various co-chaperones, such as FK506-binding protein 51, on Hsp90-mediated tau processing.
Review
Biochemistry & Molecular Biology
Raquel Gomez-Sintes, Esperanza Arias
Summary: Chaperone-mediated autophagy (CMA) is a proteolytic process that selectively degrades intracellular proteins inside lysosomes, participating in the modulation of specific regulatory proteins. Impairment of CMA function may contribute to the pathogenesis of neurodegenerative diseases and cancer, making it a potential therapeutic target for these conditions. Recent evidence has revealed the important and complex role of CMA in cancer biology, with implications for tumor development and the response to cancer therapeutics.
MOLECULAR ASPECTS OF MEDICINE
(2021)
Article
Polymer Science
Fei Deng, Menglin Yang, Yanli Zhang, Xiaohui Wu, Rujiang Ma, Feihe Ma, Linqi Shi
Summary: By developing a one-pot strategy to synthesize high-concentration MSPMs, it is possible to mass produce nanochaperones for refolding denatured proteins and stabilizing the structure of native proteins. This simple method provides a way to promote the practical applications of functional nanochaperones.
Article
Chemistry, Medicinal
Richa Sharma, Tulika Srivastava, Alka Raj Pandey, Tripti Mishra, Bhagyashri Gupta, Sabbu Sathish Reddy, Suriya P. Singh, Tadigoppula Narender, Aradhya Tripathi, Balasubramanian Chandramouli, Koneni V. Sashidhara, Smriti Priya, Niti Kumar
Summary: The study identified a flavonoid glycoside, C-10, as a pharmacological chaperone for proteins implicated in protein aggregation diseases, demonstrating its ability to stabilize proteins, prevent aggregation, and mitigate associated cytotoxic effects.
Article
Polymer Science
Xin Zong, Shuo Wang, Ning Li, Hongyu Li, Xinping Zhang, Aihua He
Summary: Chloroprene rubber (CR) modified with trans-1,4-poly (butadiene-co-isoprene) copolymer (TBIR) showed improved fluidity, plasticity and processing safety. Microphase separation morphology was observed in the un-vulcanized CR/TBIR blends, with a recommended blend ratio of CR/TBIR (90/10) for potential applications in conveyor belts, vibration dampers, etc.
Article
Materials Science, Multidisciplinary
Yang Su, Ze-Fan Yao, Bin Wu, Yu-Dong Zhao, Jing-Yu Han, Ji-Hao Sun, Ming-Peng Zhuo, Jian-Zhong Fan, Zuo-Shan Wang, Jian Pei, Liang-Sheng Liao, Xue-Dong Wang
Summary: In this study, a novel strategy for continuous regulation of emission colors was proposed by modulating crystal nuclei and growth rates for different crystal phases in organic polymer-based alloy microwires. These microwires showed potential applications in multicolor display and optical waveguides for advanced photonics.
Review
Neurosciences
Eiko N. Minakawa, Yoshitaka Nagai
Summary: Polyglutamine diseases are a group of inherited neurodegenerative disorders caused by abnormal expansion of CAG trinucleotide repeats. Stabilizing protein conformation and inhibiting aggregation offer promising therapeutic approaches, while gene silencing to reduce expression of expanded polyQ proteins is another potential treatment avenue. These advancements hold promise for delaying or preventing the progression of currently incurable diseases.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biology
Benjamin Pillet, Alfonso Mendez-Godoy, Guillaume Murat, Sebastien Favre, Michael Stumpe, Laurent Falquet, Dieter Kressler
Summary: This study reveals the protective role of co-translational recognition on the degradation of Rpl3 and Rpl4 encoding genes, and identifies the regulatory function of dedicated chaperones in the assembly of nascent ribosomal proteins.
Review
Green & Sustainable Science & Technology
Sabah Mariyam, Muhammad Shahbaz, Tareq Al-Ansari, Hamish R. Mackey, Gordon McKay
Summary: Sustainable energy resources offer a solution to the increasing energy demand caused by population growth and national development. Converting biomass waste into energy through thermochemical processing methods has environmental advantages and increased energy efficiency. This review focuses on the production of gaseous fuel, specifically syngas, from the co-conversion of biomass with other waste. Results indicate that mixing coal with biomass reduces emissions and increases gas yields.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2022)
Article
Plant Sciences
Srikanth Tengli, Swetha Thavarekere Narasimhamurthy, Appanna Koppad, Geetha Govind, Basavaiah Mohan Raju
Summary: Multiple signals, including photoperiod and temperature, regulate tuberization in potato. This study investigates the effect of shoot and root zone temperatures on tuberization. The results show that elevated temperatures reduce tuberization and root temperature is more crucial than shoot temperature. Additionally, the reduction in tuberization at high temperature is correlated with the expression of key regulators.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2022)
Review
Plant Sciences
Indu Santhanagopalan, Rachel Wong, Tanya Mathur, Howard Griffiths
Summary: This review examines the inducible carbon concentration mechanism (CCM) in Chlamydomonas reinhardtii, focusing on the relationship between external CO2 limitation, energetic supply, and inorganic carbon demand. It suggests that the chloroplast plays a crucial role in photosynthesis and regulates CCM induction by sending retrograde signals to the nucleus. The hypothesis is that retrograde signals associated with photorespiration and/or light stress are linked to CCM induction.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)