Review
Nutrition & Dietetics
Luca Scarallo, Paolo Lionetti
Summary: The multifactorial etiology of Crohn's Disease (CD), including genetic and environmental factors, is widely acknowledged. Diet plays a significant role in shaping gut microbiota composition and is suspected to contribute to the pathogenesis of inflammatory bowel disease (IBD). Research has focused on dietary therapies for CD management, targeting mucosal inflammation, intestinal dysbiosis, and optimization of nutritional status in pediatric CD patients.
Article
Nutrition & Dietetics
Dongsheng Bian, Xutong Liu, Cenyu Wang, Yongmei Jiang, Yubei Gu, Jie Zhong, Yongmei Shi
Summary: This study examined the association between Dietary Inflammatory Index (DII) and sarcopenia in Crohn's disease (CD) patients. The results showed that a higher DII score significantly increased the risk of sarcopenia, while a lower DII score was associated with higher appendicular skeletal muscle mass.
Article
Nutrition & Dietetics
Justyna Kikut, Karolina Skonieczna-Zydecka, Diana Sochaczewska, Agnieszka Kordek, Malgorzata Szczuko
Summary: This study compared the diet of adolescent patients with IBD to healthy controls in Poland and found differences in nutrient intake. Patients with IBD had deficiencies in certain nutrients while also consuming excessive saturated fatty acids and sodium. Nutritional care by dieticians should be provided alongside outpatient care, and supplementation with specific components may be considered based on the study findings.
Article
Gastroenterology & Hepatology
Lina Maria Goes de Codes, Ana Carolina Costa de Jesus, Joao Jorge Goes de Codes, Reginaldo Freitas Ferreira, Carolina da Silva Beda Sacramento, Isabela Dias Marques da Cruz, Flavia de Castro Ribeiro Fidelis, Alexandre Lopes de Carvalho, Marina Pamponet Motta, Candida de Oliveira Alves, Eduardo Martins Netto, Genoile Oliveira Santana
Summary: This study aimed to assess anorectal function and clinical characteristics associated with faecal incontinence in Crohn's disease (CD) patients. Among the 104 CD patients, 49% had faecal incontinence, and it was associated with lower resting and squeeze pressures, as well as lower maximum rectal capacity. Faecal incontinence was also related to disease activity, loose stools, perianal disease, previous anoperineal surgery, and the number of anorectal surgeries.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Nutrition & Dietetics
Alexandra Karachaliou, Mary Yannakoulia, Maria Bletsa, Gerassimos J. Mantzaris, Emmanuel Archavlis, George Karampekos, Maria Tzouvala, Giorgos Bamias, George Kokkotis, Meropi D. Kontogianni
Summary: This study evaluated the dietary intake of patients with Crohn's Disease (CD) and found that both under- and over-nutrition were prevalent during active disease and remission. The study also showed that patients generally did not meet the recommended dietary intake and had a moderate dietary quality.
Article
Pharmacology & Pharmacy
Beatriz Orts, Ana Gutierrez, Lucia Madero, Laura Sempere, Ruben Frances, Pedro Zapater
Summary: There are differences in the immunological profile and clinical evolution of patients with Crohn's disease according to the anti-TNF dose and serum trough levels.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Rafael Martin-Masot, Marta Herrador-Lopez, Victor Manuel Navas-Lopez
Summary: Alterations in gut microbiota play a crucial role in the development of inflammatory bowel disease (IBD), and modifying it through specific diets is an emerging treatment approach. This study aimed to assess changes in dietary habits and long-term adherence to Crohn's disease exclusion diet (CDED) in CD patients after one year. The KIDMED questionnaire and food consumption frequency questionnaire were used to analyze dietary habit modification and adherence to the Mediterranean diet (MD). Data analysis showed that all patients exhibited improvement in their dietary patterns, with reduced intake of ultra-processed foods, higher adherence to MD, decreased intake of certain foods, increased intake of specific foods, and sustained adherence to the dietary regimen.
Article
Nutrition & Dietetics
Luz Adriana Meneses-Urrea, Manuel Vaquero-Abellan, Dolly Villegas Arenas, Narly Benachi Sandoval, Mauricio Hernandez-Carrillo, Guillermo Molina-Recio
Summary: This study explores the factors associated with dietary patterns in Colombia using secondary data from the National Survey of Nutritional Status of Colombia. The findings indicate that cultural, social, economic, and biological factors influence food choices. Individuals with diabetes and hypertension tend to have traditional and conservative dietary patterns, while women are more likely to follow a conservative pattern and those in the first and second wealth levels are more likely to follow a traditional pattern.
Article
Gastroenterology & Hepatology
Alessandro Agostini, Francesca Benuzzi, Daniela Ballotta, Fernando Rizzello, Paolo Gionchetti, Nicola Filippini
Summary: We identified morphological and functional brain changes associated with different stages of disease activity in Crohn's disease. These findings may provide insights into the neural correlates of symptoms and impairments in CD, and could be valuable for evaluating disease progression.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Rotem Sigall Boneh, Johan Van Limbergen, Eytan Wine, Amit Assa, Ron Shaoul, Peri Milman, Shlomi Cohen, Michal Kori, Sarit Peleg, Avi On, Hussein Shamaly, Lee Abramas, Arie Levine
Summary: Dietary therapies such as CDED and EEN induce rapid clinical response in pediatric patients with active CD, with 82-85% of patients showing a rapid response by week 3. Identifying patients with and without a rapid response to diet can help predict clinical remission by week 6, with compliance playing a crucial role in treatment outcomes.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Engineering, Biomedical
Jingbo Zhao, Donghua Liao, Rune Wilkens, Klaus Krogh, Henning Glerup, Hans Gregersen
Summary: This study aimed to quantify the mechanical properties of intestinal stenosis in CD patients and found that the changes in mechanical properties were mainly associated with chronic inflammation, fibrosis, and collagen fraction.
ACTA BIOMATERIALIA
(2021)
Article
Gastroenterology & Hepatology
Emily C. L. Wong, Parambir S. Dulai, John K. Marshall, Vipul Jairath, Walter Reinisch, Neeraj Narula
Summary: Disease duration of less than 5 years is associated with clinical remission at the end of induction in Crohn's disease patients. Strategies to reduce placebo response rates in clinical trials should consider stratification or exclusion based on disease duration and mild disease severity as measured by objective biomarkers.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Su-Mi Lee, Kyung-Hwa Lee, Seon-Young Park, Dong Hyun Kim, Jin Ook Chung, Jae Kyun Ju, Jae-Hyuk Lee, Hyun Soo Kim
Summary: The mucosal expression of Cyr61 in CD patients was inversely associated with clinical course, with higher expression of Cyr61 correlating with lower recurrence rates. Further studies are needed to determine whether Cyr61 plays a role in activating inflammatory responses and promoting wound healing in CD patients.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Charlotte M. Verburgt, Katherine A. Dunn, Mohammed Ghiboub, James D. Lewis, Eytan Wine, Rotem Sigall Boneh, Konstantinos Gerasimidis, Raanan Shamir, Susanne Penny, Devanand M. Pinto, Alejandro Cohen, Paul Bjorndahl, Vaios Svolos, Joseph P. Bielawski, Marc A. Benninga, Wouter J. de Jonge, Johan E. Van Limbergen
Summary: This study found that successful dietary therapy can correct dysbiosis in pediatric Crohn's disease (CD) patients, but 12 weeks of dieting is not enough to achieve complete correction. Composition and metabotype are important and change quickly during the early clinical response to dietary intervention. Correction of dysbiosis may be an important future treatment goal for CD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Medicine, General & Internal
Lorenzo Bertani, Claudia DAlessandro, Marco Fornili, Francesca Coppini, Federico Zanzi, Luca Carmisciano, Francesca Geri, Giovanni Baiano Svizzero, Emma Maria Rosi, Alice De Bernardi, Linda Ceccarelli, Maria Gloria Mumolo, Laura Baglietto, Massimo Bellini, Nicola De Bortoli, Francesco Costa
Summary: The study aimed to evaluate the impact of ustekinumab on body composition in patients with Crohn's disease. The results showed that ustekinumab treatment could modify body composition indicators in CD patients, with a significant improvement in nutritional status observed in responders.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Renan Fudoli Lins Vieira, Vitor Rosetto Munoz, Rafael Lima Junqueira, Fellipe de Oliveira, Rafael Calais Gaspar, Susana Castelo Branco Ramos Nakandakari, Suleyma de Oliveira Costa, Marcio Alberto Torsoni, Adelino S. R. da Silva, Dennys Esper Cintra, Leandro Pereira de Moura, Eduardo Rochete Ropelle, Iman Zaghloul, Rania A. Mekary, Jose Rodrigo Pauli
Summary: Time-restricted feeding (TRF) alone can reduce weight gain and increase fatty acid oxidation, while TRF combined with aerobic exercise (TRF+Exe) shows additional benefits such as increased oxygen consumption and ketone body production. TRF+Exe also attenuates the negative effects of high-fat diet on insulin signaling pathway and leads to improved liver metabolism and glucose homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Food Science & Technology
Penelope Lacrisio Reis Menta, Maria Emilia Rabelo Andrade, Livia Furquim de Castro, Luisa Martins Trindade, Melissa Tainan Silva Dias, Josiane Erica Miyamoto, Raisa Magno dos Santos, Geovanni Dantas Cassali, Raquel Franco Leal, Ana Paula Badan Ribeiro, Renato Grimaldi, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni, Adriana Souza Torsoni, Valbert Nascimento Cardoso, Marciane Milanski
Summary: The study suggests that adding interesterified fat to a normal lipid diet may have adverse effects on intestinal mucosa, leading to increased intestinal permeability, bacterial translocation, and damage to the intestinal epithelium.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Lucas Dantas Maia Forte, Natalia de Almeida Rodrigues, Andre Vitor Cordeiro, Thais de Fante, Lais Angelica de Paula Simino, Adriana de Souza Torsoni, Marcio Alberto Torsoni, Claudio Alexandre Gobatto, Fulvia Barros Manchado-Gobatto
Summary: The acute metabolic and molecular response to exercise may differ depending on the intensity and duration of the exercise. This study investigated the effects of acute exercise at different intensities, but with equal total load, on molecular and physiological responses in swimming rats. The results showed that blood lactate concentration was the only biomarker sensitive to acute exercise, and hepatic and muscle glycogen depletion and gene expression changes were associated with exercise intensity.
JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY
(2022)
Article
Biochemistry & Molecular Biology
Carolina Panzarin, Lais Angelica de Paula Simino, Mariana Camargo Silva Mancini, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Adriana Souza Torsoni
Summary: The modulation of hepatic miR-370-122-Let7 miRNA may play a crucial role in the early stages of NAFLD, preceding changes in glycemic homeostasis and adiposity.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Cell Biology
Lais A. de Paula Simino, Marina Figueiredo Fontana, Thais de Fante, Carolina Panzarin, Leticia Martins Ignacio-Souza, Marciane Milanski, Marcio Alberto Torsoni, Mina Desai, Michael G. Ross, Adriana Souza Torsoni
Summary: Obesity during pregnancy increases the risk of non-alcoholic fatty liver disease in offspring. However, the offspring of obese dams are able to overcome epigenetic changes and regenerate liver tissue after partial hepatectomy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Camila Libardi do Amaral, Isis de Cassia Alves Martins, Alana Carolina Costa Veras, Fernando Moreira Simabuco, Michael Glenn Ross, Mina Desai, Leticia Martins Ignacio-Souza, Marciane Milanski, Adriana Souza Torsoni, Marcio Alberto Torsoni
Summary: This study demonstrates that activation of alpha 7nAchR anti-inflammatory signaling in hypothalamic neurons exerts neuroprotective effects and prevents the development of insulin resistance induced by pro-inflammatory mediators secreted by microglial cells.
Article
Clinical Neurology
Milca Abda Morais, Beatriz Silva Franco, Alessandro Spencer Souza Holanda, Lais Angelica de Paula Simino, Alana Carolina Costa Veras, Marcio Alberto Torsoni, Mauro Manconi, Adriana Souza Torsoni, Andrea Maculano Esteves
Summary: The pathophysiology of restless legs syndrome (RLS) is related to dopaminergic dysfunction, reduced iron, and variations in gene expression. This study used spontaneously hypertensive rats (SHR) as an animal model to evaluate gene and protein expression, sleep patterns, and cardiovascular parameters associated with RLS. The study found that SHR had higher blood pressure, altered sleep patterns, lower expression of certain proteins and genes, and lower serum concentrations of ferritin.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Mina Desai, Adrianna S. Torsoni, Marcio A. Torsoni, Agnlia Eisaghalian, Monica G. Ferrini, Michael G. Ross
Summary: Developmental programming studies using mouse models have investigated the effects of different housing temperatures on obesity development in offspring. The results showed that male offspring displayed increased body weight and adiposity when housed at thermoneutral temperature, while female offspring were not affected by housing temperature.
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2023)
Article
Endocrinology & Metabolism
Robert Haddad Tovolli, Joseane Morari, Roberta Barbizan, Vanessa C. Bobbo, Rodrigo S. Carraro, Carina Solon, Nathalia R. Dragano, Marcio A. Torsoni, Eliana P. Araujo, Licio A. Velloso
Summary: Maternal obesity is a significant risk factor for obesity, cardiovascular, and metabolic diseases in offspring. It leads to inflammation in the hypothalamus of the offspring, affecting the function of neurons that regulate food intake and energy expenditure. Maternal obesity-induced structural and functional damage to the offspring's hypothalamic BBB, but breastfeeding by lean mothers can partially reverse these effects.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Biochemistry & Molecular Biology
Keryma Chaves da Silva Mateus, Ivan Luiz Padilha Bonfante, Amanda Veiga Sardeli, Renata Garbellini Duft, Arthur Fernandes Gaspari, Joice Cristina dos Santos Trombeta, Joseane Morari, Bruno Rodrigues, Marcio Alberto Torsoni, Mara Patricia Traina Chacon-Mikahil, Licio Augusto Velloso, Claudia Regina Cavaglieri
Summary: The aim of this study was to investigate the effects of different types of exercise on the expression of CHRNA7, CHRFAM7A, and TNF-alpha genes in individuals with normal weight and overweight with type 2 diabetes. The results showed that individuals with overweight and type 2 diabetes had higher baseline expression of CHRFAM7A and TNF-alpha. However, after exercise, the expression of CHRFAM7A increased in individuals with normal weight, especially in aerobic exercise.
Article
Food Science & Technology
Alana Carolina Costa Veras, Larissa da Silva Bruzasco, Ana Beatriz Profiro Lopes, Beatriz da Silva Franco, Alessandro Spencer de Souza Holanda, Andrea Maculano Esteves, Marciane Milanski, Adriana Souza Torsoni, Leticia Martins Ignacio-Souza, Marcio Alberto Torsoni
Summary: The consumption of saturated fatty acids in coconut oil can lead to insulin and leptin resistance, inflammation, and obesity. This study investigated the effects of coconut oil supplementation on leptin signaling in healthy mice. The results showed that coconut oil induced endoplasmic reticulum stress and leptin resistance in the hypothalamus, favored lipogenesis in adipose tissue, and impaired STAT3 and JAK2 signaling.
JOURNAL OF FUNCTIONAL FOODS
(2023)