Improvement in Aqueous Solubility of Retinoic Acid Receptor (RAR) Agonists by Bending the Molecular Structure

Novel tactics for designing water-soluble molecules in drug discovery

(2014) Michael A Walker   Expert Opinion on Drug Discovery

Carnelley's Rule and the Prediction of Melting Point

(2014) Samuel H. Yalkowsky   JOURNAL OF PHARMACEUTICAL SCIENCES

An Inexpensive Aqueous Flow Battery for Large-Scale Electrical Energy Storage Based on Water-Soluble Organic Redox Couples

(2014) Bo Yang et al.   JOURNAL OF THE ELECTROCHEMICAL SOCIETY

An Uncharged Oxetanyl Sulfoxide as a Covalent Modifier for Improving Aqueous Solubility

(2014) Erin M. Skoda et al.   ACS Medicinal Chemistry Letters

Design, synthesis, and evaluation of novel VEGFR2 kinase inhibitors: Discovery of [1,2,4]triazolo[1,5-a]pyridine derivatives with slow dissociation kinetics

(2013) Yuya Oguro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small-Molecule Inhibitors of Cytokine-Mediated STAT1 Signal Transduction in β-Cells with Improved Aqueous Solubility

(2013) Stephen S. Scully et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure–Activity Relationships and Molecular Modeling of Sphingosine Kinase Inhibitors

(2013) Dong Jae Baek et al.   JOURNAL OF MEDICINAL CHEMISTRY

Solubilities of selected organic electronic materials in pressurized hot water and estimations of aqueous solubilities at 298.15K

(2012) Pavel Karásek et al.   CHEMOSPHERE

Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors

(2012) J. Osz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyrazolopyridine inhibitors of B-RafV600E. Part 3: An increase in aqueous solubility via the disruption of crystal packing

(2011) Steve Wenglowsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Confirmation of Molecular Planarity Disruption Effect on Aqueous Solubility Improvement of β-Naphthoflavone Analogs

(2011) Minoru Ishikawa et al.   HETEROCYCLES

Improvement in Aqueous Solubility in Small Molecule Drug Discovery Programs by Disruption of Molecular Planarity and Symmetry

(2011) Minoru Ishikawa et al.   JOURNAL OF MEDICINAL CHEMISTRY

Improvement of water-solubility of biarylcarboxylic acid peroxisome proliferator-activated receptor (PPAR) δ-selective partial agonists by disruption of molecular planarity/symmetry

(2010) Jun-ichi Kasuga et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Protein Knockdown Using Methyl Bestatin−Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins

(2010) Yukihiro Itoh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Naphthoflavone analogs as potent and soluble aryl hydrocarbon receptor agonists: Improvement of solubility by disruption of molecular planarity

(2009) Yuji Fujita et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Organic Synthesis “On Water”

(2009) Arani Chanda et al.   CHEMICAL REVIEWS

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

(2009) Frank Lovering et al.   JOURNAL OF MEDICINAL CHEMISTRY

One-pot Synthesis of Benzo[b]thiophenes and Benzo[b]selenophenes fromo-Halo-Substituted Ethynylbenzenes: Convenient Approach to Mono-, Bis-, and Tris-Chalcogenophene-Annulated Benzenes

(2009) Tomoya Kashiki et al.   ORGANIC LETTERS

Molecular Characteristics for Solid-State Limited Solubility

(2008) Carola M. Wassvik et al.   JOURNAL OF MEDICINAL CHEMISTRY