Article
Pharmacology & Pharmacy
Ruby Singh, Purandhi Roopmani, Meenakshi Chauhan, Suparna Mercy Basu, Waghela Deeksha, M. D. Kazem, Sarbani Hazra, Eerappa Rajakumara, Jyotsnendu Giri
Summary: In this study, dressing materials with dual properties of anti-bacterial and regenerative were developed for complex and large asymmetric burns. The results demonstrated sustained release of silver sulfadiazine (SSD) and concentration-dependent antibacterial activity. The airbrushed nanofibers showed biocompatibility, supported the differentiation and regeneration of cells, and facilitated complete recovery of burn wounds in rabbit models. The core-shell nanofibers displayed anti-inflammatory and proliferative activity without adverse tissue response.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Longbao Feng, Yu Liu, Yini Chen, Qi Xiang, Yadong Huang, Zonghua Liu, Wei Xue, Rui Guo
Summary: This study developed a biomaterial called RQLAg hydrogel, which has antibacterial and wound-healing properties. By fusing silver nanoparticles with antibacterial properties and asiaticoside-loaded liposomes with anti-inflammatory/vascularization effects into a hydrogel with a special porous structure, the hydrogel shows sustained release capabilities of silver ions and asiaticoside, as well as concentration-dependent swelling properties, pore size, and compressive strength. Cellular experiments demonstrate that the hydrogel has good cell compatibility and promotes cell migration, angiogenesis, and M1 macrophage polarization. In addition, the hydrogel exhibits excellent antibacterial activity against Escherichia coli and Staphylococcus aureus. In vivo experiments on rats show that the RQLAg hydrogel efficiently promotes wound healing and has stronger healing promoting abilities compared to Aquacel Ag. In summary, the RQLAg hydrogel is expected to be an excellent material for accelerating open wound healing and preventing bacterial infections.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Inorganic & Nuclear
Somlingesh L. Shidramshettar, Laxman S. Vijapur, Mallappa Shalavadi, Anita R. Desai, Avinash S. Gudigennavar, Y. Srinivas
Summary: This study successfully synthesized silver nanoparticles using aqueous leaf extract of Achyranthes aspera and investigated their potential for burn wound healing. The synthesized nanoparticles exhibited antioxidant and antimicrobial activity, and showed enhanced wound healing effects through fibroblast differentiation and keratinocyte proliferation. This research is of importance in exploring new approaches for burn treatment.
INORGANIC CHEMISTRY COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Xushan Chen, Huimin Zhang, Xin Yang, Wuhong Zhang, Ming Jiang, Ting Wen, Jie Wang, Rui Guo, Hanjiao Liu
Summary: Infection is a major cause of death from burns, and traditional dressings are ineffective at inhibiting bacterial growth; a new hydrogel design shows excellent antibacterial activity and fast wound healing, promising to be a significant advancement in wound dressings.
Article
Immunology
Yao Zhang, Hidetaka Ideguchi, Hiroaki Aoyagi, Keisuke Yamashiro, Tadashi Yamamoto, Masahiro Nishibori, Shogo Takashiba
Summary: Malnutrition leads to delayed wound healing by potentially interfering with the HMGB1-IL-1 beta inflammatory response cascade. This study observed changes in related factors in a malnutrition mouse model and identified the mechanism of delayed wound healing.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Na Li, Wan Liu, Xiaoyan Zheng, Qing Wang, Lixin Shen, Junfeng Hui, Daidi Fan
Summary: Burns are a common medical problem worldwide, with wound infection as a major complication. To tackle this issue, a new strategy has been proposed to develop a pH-responsive antimicrobial P-ZIF by loading PHMB into ZIF-8 nanoparticles. These nanoparticles can release PHMB in the weak acid environment of an infected wound. Furthermore, P-ZIF nanoparticles were incorporated into a hydrogel dressing made of SA and H-A, which exhibited antibacterial and wound healing properties with dual pH responsiveness. The P-ZIF nanoparticles and corresponding hydrogel dressing are highly significant in antimicrobial, drug delivery, and wound repair applications.
Article
Engineering, Multidisciplinary
Thuy Thi Thanh Nguyen, Ngan Thi Kim Tran, Tu Quoc Le, Tuyet Thi Anh Nguyen, Lan Thi My Nguyen, Thuan Van Tran
Summary: This study focused on the influence of biosynthesized silver nanoparticles (AgNPs) on the characteristics of passion fruit peel pectin/chitosan (P/CH) biofilms. The results showed that incorporating AgNPs into P/CH-based films significantly affected the color and optical properties of the biofilms. The P/CH/AgNPs biofilms exhibited outstanding antibacterial properties and excellent wound closure, making them promising for biomedical applications.
ALEXANDRIA ENGINEERING JOURNAL
(2023)
Article
Polymer Science
Doaa Alshora, Lubna Ashri, Rihaf Alfaraj, Ahlam Alhusaini, Raeesa Mohammad, Nawal Alanaze, Mohamed Ibrahim, Mohamed Badran, Mounir Bekhit, Shaikha Alsaif, Modhi Alagili, Rehab Ali, Adel Jreebi
Summary: This study aims to formulate a biofilm composed of silver sulfadiazine, chitosan, and sodium alginate, and evaluate its effectiveness in wound healing. The optimized formulation showed reasonable mechanical properties and significantly higher antibacterial activity compared to the blank biofilm. In vivo study demonstrated a 75% reduction in wound width with the formulated biofilm.
Article
Chemistry, Multidisciplinary
Jiaojiao Zhu, Tiao Wen, Shuangquan Qu, Qingnian Li, Biwu Liu, Wenhu Zhou
Summary: This study developed a multifunctional silver nanoclusters-based hydrogel dressing for the treatment of infected wounds. The dressing has the capability to simultaneously fight infection and promote wound healing, showing excellent therapeutic efficacy in a mouse model of infected wounds.
Review
Biology
Mateusz Rybka, Lukasz Mazurek, Marek Konop
Summary: Impaired wound healing is a global problem affecting millions of people, leading to chronic wounds that are susceptible to infections. A shift in the antibacterial treatment paradigm is necessary due to the rising bacterial resistance against antibiotics. Silver nanoparticles have emerged as a promising candidate for the treatment of chronic wounds, with their antimicrobial, anti-inflammatory, and anti-oxidative properties. This review article focuses on experimental and clinical studies on dressings containing silver or silver nanoparticles, highlighting their potential in wound healing.
Review
Biochemistry & Molecular Biology
Manoj Singh, Vanita Thakur, Vikas Kumar, Mayank Raj, Shivani Gupta, Nisha Devi, Sushil Kumar Upadhyay, Marketa Macho, Avik Banerjee, Daniela Ewe, Kumar Saurav
Summary: Wounds are disruptions of skin caused by trauma, surgery, or disease. The healing process is complex and involves inflammatory response, proliferation, and tissue remodeling. Understanding and developing novel therapeutics for these processes are important for achieving maximum recovery. Metal nanoparticles, such as silver, gold, and zinc, have shown promise in wound healing and preventing infections.
Review
Chemistry, Medicinal
Christian Oktavianus Manginstar, Trina Ekawati Tallei, Nurdjannah Jane Niode, Christina Leta Salaki, Sofia Safitri Hessel
Summary: This literature review provides an overview of propolis' mechanisms of action, wound-healing properties, and its application in treating skin burns. Propolis contains bioactive compounds with antimicrobial, antioxidant, and anti-inflammatory properties, making it a promising candidate for managing skin burn injuries. Further research is needed to fully understand propolis' mechanisms, determine optimal formulations, and establish suitable clinical dosages.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemical Research Methods
Chengzhi Liang, Jing He, Yuan Cao, Guoming Liu, Chengdong Zhang, Zhiping Qi, Chuan Fu, Yanling Hu
Summary: Skin is the body's largest organ, providing a crucial barrier against chemical, radiological, and microbial damage. Delayed wound healing is a major healthcare challenge and can have serious consequences. Many wound dressings have been developed to promote faster healing and prevent microbial invasion, some of which contain bioactive nanoparticles. MXene nanoparticles have attracted attention for their unique properties and potential as functional components in wound dressings.
JOURNAL OF BIOLOGICAL ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Jianrui Qi, Jie Zhang, Hang Jia, Xinyuan Guo, Yuan Yue, Yahong Yuan, Tianli Yue
Summary: This study successfully developed a low-cost antibacterial nanobiomaterial with strong antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as good biocompatibility. In vivo assays confirmed that the nanocomposite not only promoted the healing of wound infection caused by bacteria, but also had no toxic effect on mouse organs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Immunology
Bolin Wang, Jianle Chen, Chuwei Zhang, Qingrong Zhang, Zhihan Zhu, Ling Qiu, Jun Yan, Zihan Li, Xinghua Zhu, Yi Zhang, Yun Jiang
Summary: This study demonstrates the potential of a novel delivery system, the platelet membrane-coated nanoparticle complex, in effectively delivering bFGF and VEGFA genes to deep burn wounds and promoting wound healing.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Xiao-li Xiong, Kenneth Kak-yuen Wong, Shui-qing Chi, Ai-fen Zhou, Jian-qiao Tang, Li-shan Zhou, Patrick Ho-yu Chung, Gilbert Chua, Ketih Tung, Ian Wong, Celine Chui, Xue Li, Mike Yat-wah Kwan, Wilfred Hing-sang Wong, Marco Hok-kung Ho, Godfrey Chi-fung Chan, Guo-qing Cao, Kang Li, Patrick Ip, Peng Chen, Shao-tao Tang, Paul Kwong-hang Tam
Article
Pediatrics
Adrian Chi Heng Fung, Anita Sik Yau Kan, Patrick H. Y. Chung, Noel Wing Man Shek, Ivy Hau Yee Chan, Kenneth Kak Yuen Wong
Summary: This study reviewed the experience of a tertiary paediatric surgery and obstetric centre on prenatal counselling of congenital surgical anomalies. It found that a multidisciplinary approach, combined-specialty consultations, and counselling deliver valuable information for parents. Congenital surgical anomalies significantly impact perinatal outcomes and morbidity in later infancy and childhood, emphasizing the importance of implementing a comprehensive approach.
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2021)
Article
Immunology
Yao-Yao Chang, Qiu-Chan Huan, Jiao Peng, Wen-Chun Bi, Li-Xiang Zhai, Yan Chen, Jonathan R. Lamb, Xiang-Chun Shen, Zhao-Xiang Bian, Hai-qiang Wu, Yong-Xian Cheng, Hai-Tao Xiao
Summary: This study found that P2Y1R deficiency can suppress Th17 cell differentiation in an AMPK-dependent manner to ameliorate colitis, and P2Y1R can act as an important regulator of Th17 cell differentiation to control colonic inflammation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Vincent Chi-Hang Lui, Kenrie Pui-Yan Hui, Rosanna Ottakandathil Babu, Haibing Yue, Patrick Ho-Yu Chung, Paul Kwong-Hang Tam, Michael Chi-Wai Chan, Kenneth Kak-Yuen Wong
Summary: This study found that intra-hepatic bile duct cells are susceptible to SARS-CoV-2 infection and support efficient viral replication. The replication level of SARS-CoV-2 is much higher than that of SARS-CoV. These findings suggest that direct cytopathic viral damage is a mechanism for SARS-CoV-2 liver injury.
SCIENTIFIC REPORTS
(2022)
Review
Pediatrics
Adrian Chi-heng Fung, Felicia Yin -to Chu, Ivy Hau-yee Chan, Kenneth Kak-yuen Wong
Summary: The current status of enhanced recovery after surgery (ERAS) protocols in pediatric urology was reviewed. Eight clinical studies have been published, demonstrating the efficacy of ERAS in pediatric urology. Further prospective studies are needed to formulate standardized protocols and optimize surgical outcomes.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Letter
Gastroenterology & Hepatology
Ruizhong Zhang, Junyu Huang, Jiarou Shan, Yan Chen, Huimin Xia
JOURNAL OF HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Zhixin Li, Kathy Nga-Chu Lui, Sin-Ting Lau, Frank Pui-Ling Lai, Peng Li, Patrick Ho-Yu Chung, Kenneth Kak-Yuen Wong, Paul Kwong-Hing Tam, Maria-Mercedes Garica-Barcelo, Chi-Chung Hui, Pak Chung Sham, Elly Sau-Wai Ngan
Summary: Using induced pluripotent stem cell-based models and single-cell transcriptomic analysis, the study identifies a set of 118 commonly dysregulated genes in enteric neural crest cells of Hirschsprung disease patients, and suggests HDAC1 as a key regulator of these genes. The study also reveals that upregulation of RNA splicing mediators and enhanced alternative splicing events are associated with severe form of the disease. Overall, the research defines various factors associated with Hirschsprung pathogenesis.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Pediatrics
Hiroo Uchida, Gregory M. M. Tiao, Pranavkumar Shivakumar, Kenneth K. Y. Wong, Akihiro Asai, Hizuru Amano
FRONTIERS IN PEDIATRICS
(2023)
Letter
Pediatrics
Adrian Chi Heng Fung, Kenneth Kak Yuen Wong
WORLD JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Adrian C. H. Fung, Matthew H. L. Lee, Jessie L. Leung, Ivy H. Y. Chan, Kenneth K. Y. Wong
Summary: This study evaluates the readability, quality, and accuracy of health information about nocturnal enuresis. The findings suggest that most websites providing information on this condition are of suboptimal quality, readability, and accuracy.
EUROPEAN JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Adrian Chi-Heng Fung, Henry Yongqin Ye, Tiffany Wing -See Lau, Vincent Chi -hang Lui, Kenneth Kak-Yuen Wong
Summary: This study compared the effects of non-absorbable monofilament and multifilament sutures on the vas deferens during laparoscopic hernia repair. The findings showed that using silk sutures resulted in a reduced cross-sectional area of the vas deferens and increased tissue adhesion.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Sze-ting Christie Lau, Louise Bik-yu Ting, Adrian Chi-heng Fung, Eugene Chin-tung Lau, Kenneth Kak-yuen Wong
Summary: This article reports a case of a 10-year-old Chinese girl who presented with right lower quadrant pain and fever. Initially misdiagnosed as acute appendicitis, a CT scan revealed a fish bone in the cecum causing perforation. Laparoscopy was performed to remove the fish bone and repair the perforation. It is important to consider intestinal perforation caused by swallowed foreign objects in children with acute abdominal pain.
JOURNAL OF PEDIATRIC SURGERY CASE REPORTS
(2023)
Editorial Material
Pediatrics
Adrian Chi Heng Fung, Kenneth Kak Yuen Wong
BMJ PAEDIATRICS OPEN
(2023)
Article
Pediatrics
Adrian Chi Heng Fung, Man Kei Lee, Michael Pak Kiu Lui, Long Yam Lip, Patrick Ho Yu Chung, Kenneth Kak Yuen Wong
Summary: This study compared the outcomes of primary anastomosis (PA) and enterostomy as treatments for neonatal intestinal atresia, and identified factors influencing the choice of surgical approach. The results showed that both approaches had comparable clinical outcomes, but the PA group had shorter hospital stays, fewer complications and reoperations, and was suitable for patients with proximal atresia. Enterostomy remained a sensible choice for patients with smaller body sizes and lower Apgar scores.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Ye Peng, Lin Zhang, Chris K. P. Mok, Jessica Y. L. Ching, Shilin Zhao, Matthew K. L. Wong, Jie Zhu, Chunke Chen, Shilan Wang, Shuai Yan, Biyan Qin, Yingzhi Liu, Xi Zhang, Chun Pun Cheung, Pui Kuan Cheong, Ka Long Ip, Adrian C. H. Fung, Kenneth K. Y. Wong, David S. C. Hui, Francis K. L. Chan, Siew C. Ng, Hein M. Tun
Summary: This study identified potential microbiota-based adjuvants that may extend the durability of immune responses to COVID-19 vaccines.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)