Article
Surgery
Hyunsuk Oh, Sangno Lee, Jungtae Na, Ju Hee Kim
Summary: The study evaluated the properties, safety, and efficacy of a novel composite filler consisting of cross-linked HA with PN in combination with monodisperse PLLA microspheres. Results showed that the composite filler had higher viscosity and elasticity values, and demonstrated non-toxicity in both in vitro and in vivo tests, indicating its potential safety for human use. Additionally, the composite filler maintained a more stable volume compared to HA filler in experimental rats and supported skin structure restoration.
AESTHETIC PLASTIC SURGERY
(2021)
Article
Polymer Science
Won Lee, Nark-Kyoung Rho, Eun-Jung Yang
Summary: Although the mode of action of hyaluronic acid (HA) filler injections remains unclear, it is associated with various non-vascular inflammatory complications. Impurities in hyaluronic acid fillers may lead to an immune response. This study aimed to identify any impurities in hyaluronic acid fillers available on the market, and found contaminant particles such as silicon and aluminum isotopes.
Article
Engineering, Biomedical
Jiajing Zhao, Ziwei Chen, Xiaoshuo Li, Zheren Tong, Zijin Xu, Peishi Feng, Ping Wang
Summary: This study investigated the properties of HA/PLA composite hydrogels as dermal fillers. The results showed that the composite hydrogel had enhanced biocompatibility and biological performance, with decreased stiffness and no adverse reactions. Additionally, it exhibited excellent anti-wrinkle effects.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Multidisciplinary
Dong Gil You, Jae Yoon An, Wooram Um, Jae Min Jung, Byeong Hoon Oh, Van Quy Nguyen, Jueun Jeon, Jungmi Lee, Dong-Gyu Jo, Yong Woo Cho, Jae Hyung Park
Summary: Hyaluronic acid-based hydrogels have the potential to reduce wrinkles, while stem cell-derived extracellular vesicles can improve the dermal microenvironment, prolong collagen generation, and serve as a potential antiaging filler for reprogramming the dermis environment.
Article
Dermatology
Alexandra Bowles, Sabrina Ghalili, Oben B. Ojong, Gabriella F. Vasile, Yumeng M. Li, Shino Bay Aguilera
Summary: This study presents a case series of three patients who were successfully treated for granulomatous foreign body reaction (GFBR) caused by dermal filler. The treatment involved intralesional injection, oral medication, and laser therapy. The results showed significant improvement in both aesthetic and functional outcomes for the patients.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Surgery
Nazim Gumus, M. Baver Acaban, Hatice Oruc Demirbag
Summary: This study investigates the biological impact of hyaluronic acid (HA) in reshaping ear cartilage by injecting HA dermal filler in rabbit ears. The results show that HA can stimulate cartilage regeneration by increasing extracellular matrix synthesis and chondrogenesis, particularly in direct contact with the ear cartilage.
AESTHETIC PLASTIC SURGERY
(2022)
Article
Dermatology
M. J. Rowland-Warmann
Summary: The incidence of hypersensitivity reactions to hyaluronic acid dermal fillers is between 0.3 and 4.25%, and may be mediated by T-lymphocytes. Flu-like illness can trigger immunogenic reactions at the site of filler placement. Cases of SARS-CoV-2 may increase the risk of hypersensitivity reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Infectious Diseases
Demetris Savva, Gopi Battineni, Francesco Amenta, Giulio Nittari
Summary: The ongoing COVID-19 vaccination program presents an opportunity for public health authorities to navigate the current pandemic crisis. Reports have shown that hyaluronic acid soft tissue fillers may cause delayed inflammatory reactions following COVID-19 vaccination, emphasizing the importance of patient education prior to receiving such injections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Surgery
Laszlo Mark Czumbel, Sandor Farkasdi, Noemi Gede, Alexandra Miko, Dezso Csupor, Anita Lukacs, Valeria Gaal, Szabolcs Kiss, Peter Hegyi, Gabor Varga
Summary: This study investigated the effectiveness of hyaluronic acid (HA) for lip augmentation through meta-analysis and systematic review and found that HA injection is an efficient method for increasing lip fullness for at least up to 6 months after augmentation. The majority of treatment-related adverse effects were mild or moderate, with a small number of serious adverse effects identified. More well-designed randomized controlled trials are still needed to strengthen the existing evidence.
FRONTIERS IN SURGERY
(2021)
Article
Dermatology
Ceyhun Arici, Zeynep Tosuner
Summary: Two patients presented with subcutaneous palpable masses in the lower eyelid area after hyaluronic acid filler injection. Surgical excision revealed foreign-body granulomatous reaction, consistent with the formation of dermal filler-related granulomas years after injection. Patients should be informed about the possibility of mass formation and clinicians should be vigilant for delayed hypersensitivity reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Infectious Diseases
Luciena Cegatto Martins Ortigosa, Fabiano Carvalho Lenzoni, Maria Victoria Suarez, Artur Antonio Duarte, Luiz Euribel Prestes-Carneiro
Summary: Brazil ranked second in the world for the number of aesthetic procedures carried out in 2019. This paper presents five case reports of delayed hypersensitivity reaction to hyaluronic acid dermal filler after COVID-19 vaccination. Additional vaccination for new variants, including omicron, will be necessary; therefore, aesthetic professionals should be aware of this possibility and advise patients accordingly.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Chemistry, Multidisciplinary
So-Jung Gwak, Yu Bin Lee, Eun Joo Lee, Kyoung Hwan Park, Sun-Woong Kang, Kang Moo Huh
Summary: The market for injectable dermal fillers is booming due to growing interest in appearance management. However, the durability and retention time of hyaluronic acid (HA) hydrogels, commonly used as fillers, are limited. This study introduces acetylated hyaluronic acid-divinyl sulfone (AcHA-DVS) hydrogels as a promising solution to improve the physical properties and gel retention time of HA fillers.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Junghyun Park, Hue Jung Park, Min Cheol Rho, Jin Joo
Summary: Osteoarthritis is a degenerative disease that is spreading worldwide due to an aging population, with knee joints showing degenerative changes earlier than other joints. Intra-articular injection is a common treatment for knee osteoarthritis, but the effectiveness and uncertainties of intra-articular injection drugs are limited.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Eva Daminato, Giulio Bianchini, Valerio Causin
Summary: This study aims to develop a novel technology for manufacturing high-performance HA-based fillers with minimal amounts of crosslinking agents. The newly developed fillers, functionalized with different amounts of BDDE and formulated with CTL, showed comparable resistance against hyaluronidase, swelling, and cohesivity to commercial products. However, they demonstrated excellent elasticity and higher compression resistance, making them very promising for their lifting effect.
Article
Dermatology
Fernando Urdiales-Galvez, Francisco M. De cabo-Frances, Isabel Bove
Summary: Ultrasound examinations can help determine the nature of previous dermal filler procedures, with different patterns identified for different types of fillers. This valuable tool allows specialists to choose the best therapeutic approach for patients who have undergone aesthetic treatments in the past.
JOURNAL OF COSMETIC DERMATOLOGY
(2021)
Article
Dermatology
Hye Sung Han, Jae Wan Park, Sun Hye Shin, Kwang Ho Yoo, Young Sung Sohn, Beom Joon Kim
Summary: This study evaluated the safety and efficacy of a topical gel, DA-5520, for the treatment of different types of acne scars. The results showed that DA-5520, when combined with laser resurfacing or used alone, improved acne scars clinically, without any associated adverse reactions.
JOURNAL OF COSMETIC DERMATOLOGY
(2022)
Article
Dermatology
Hye Sung Han, Jun Ki Hong, Su Jung Park, Byung Cheol Park, Kui Young Park
Summary: The study found that both 532-nm and 1,064-nm Nd:YAG P-DOE lasers were effective in improving skin texture and pores, but the 532-nm Nd:YAG P-DOE was more effective in treating dyspigmentation.
ANNALS OF DERMATOLOGY
(2023)
Article
Dermatology
Hye Sung Han, Jun Ki Hong, Kwang Ho Yoo, Seong Jun Seo
Summary: Becker's nevus is a benign hamartoma that can cause cosmetic concerns. Current therapeutic options for Becker's nevus have limitations and can lead to adverse effects. This article explores the use of non-ablative fractional laser therapy combined with Q-switched Nd:YAG laser as a potential treatment option and reviews relevant literature to discuss its effectiveness and limitations.
ANNALS OF DERMATOLOGY
(2023)
Article
Dermatology
Hye Sung Han, Young Gue Koh, Jun Ki Hong, Yoon Jin Roh, Seong Jun Seo, Kui Young Park
Summary: This study evaluated the efficacy and safety of a topical formulation containing human adipose tissue-derived mesenchymal stem cell-derived exosomes (ASCEs) in the treatment of DFR. The results showed that ASCEs can alleviate DFR by downregulating local inflammation and restoring skin barrier function.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Dermatology
You Na Jang, Joon Seok, A. Yeon Park, Woo Geon Lee, Jung Min Lee, Yu Jin Kim, Su Young Kim, Kwang Ho Yoo, Jung Ok Lee, Beom Joon Kim
Summary: Two hair color shampoos with different dyeing principles were compared in this study. The shampoo based on hair coating enhanced the dyeing effect and roughness, while the shampoo based on hair oxidation improved the color retention and moisture content in the hair. The two products had similar effects on frictional resistance, gloss, and elasticity of the hair.
SKIN RESEARCH AND TECHNOLOGY
(2023)
Letter
Dermatology
Su Jung Park, Hye Sung Han
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Young Gue Koh, Joon Seok, Jae Wan Park, Ka Ram Kim, Kwang Ho Yoo, Yong Joon Kim, Beom Joon Kim
Summary: This study aimed to evaluate the efficacy and safety of oral palmitoleic acid in improving skin barrier, elasticity, and wrinkle formation in adult women. The results showed that palmitoleic acid significantly improved skin hydration and transepidermal water loss. However, it did not show significant improvements in skin elasticity, surface roughness, eye wrinkle volume, wrinkle severity, and participant-assessed clinical improvement score.
Article
Dermatology
Sun Young Choi, Sun Hye Shin, Joon Seok, Eun Jung Ko, Kwang Ho Yoo, Beom Joon Kim
Summary: The study found that the novel long-pulsed 1,064-nm GaAs laser showed a higher clinical improvement rate in treating onychomycosis, with less pain experienced by patients during treatment and no severe adverse events.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Hye Sung Han, Bo Ri Kim, Minjae Kim, Jung-Im Na, Suk Bae Seo, Chang-Hun Huh, Jung-Won Shin
Summary: The needleless laser-induced microjet injector is a promising transdermal drug delivery system that can deliver small and precise drug doses into the skin with minimal pain and downtime. This study compared the effectiveness of laser-induced microjet injection versus needle injection of polylactic acid/hyaluronic acid filler for skin enhancement and rejuvenation. The results showed that the laser-induced microjet injection achieved similar improvements in skin hydration and elasticity as the needle injection, but with reduced pain, side effects, and treatment time.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Dermatology
Ga Ram Ahn, You Na Jang, So Young Lee, Woo Ju Kim, Hye Sung Han, Kwang Ho Yoo, Tae Hui Bae, Jae Sang Ban, Joon Seok, Beom Joon Kim
Summary: This study evaluated the dual-depth targeting capability of a novel dual-length microneedle radiofrequency (DLMR) device on human facial skin. The results demonstrated that the DLMR device successfully induced thermal stimulation in the papillary and reticular dermis, leading to changes in the epidermis and dermis, as well as an increase in collagen content. These findings suggest the potential clinical application of the DLMR device in full-thickness skin rejuvenation.
LASERS IN SURGERY AND MEDICINE
(2023)
Article
Oncology
Jung Min Lee, Jung Ok Lee, Yujin Kim, You Na Jang, A. Yeon Park, Su-Young Kim, Hye Sung Han, Beom Joon Kim, Kwang Ho Yoo
Summary: Exosomes derived from BJ-5ta effectively prevent melanogenesis by regulating multiple signaling pathways, inhibiting melanosome transport and have potential clinical applications in treating hyperpigmentation disorders.
PIGMENT CELL & MELANOMA RESEARCH
(2023)
Letter
Dermatology
Young Gue Koh, Hye Sung Han, Joon Seok, Sun Young Choi, Kapsok Li, Beom Joon Kim, Kwang Ho Yoo
SKIN RESEARCH AND TECHNOLOGY
(2023)
Letter
Dermatology
Ka Ram Kim, Sun Hye Shin, Hye Sung Han, Kwang Ho Yoo, Beom Joon Kim, Sun Young Choi
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
