Article
Medicine, Research & Experimental
Poliana C. Marinello, Paola S. Cella, Mayra T. J. Testa, Phillipe B. Guirro, Walison Augusto da Silva Brito, Camila S. Padilha, Alessandra L. Cecchini, Robin P. da Silva, Jose Alberto R. Duarte, Rafael Deminice
Summary: This study investigated the effects of creatine supplementation on the pathogenesis of non-alcoholic fatty liver disease and alcoholic liver disease. The results showed that creatine supplementation prevented high-fat diet-induced non-alcoholic fatty liver disease but exacerbated ethanol-induced alcoholic liver disease. The exacerbating effects may be related to oxidative stress and inflammation-mediated upregulation of ethanol metabolism.
Article
Biochemistry & Molecular Biology
Marcin Kosmalski, Jozef Drzewoski, Izabela Szymczak-Pajor, Andrzej Zieleniak, Melania Mikolajczyk-Solinska, Jacek Kasznicki, Agnieszka Sliwinska
Summary: The study aimed to evaluate the association between Irisin and non-alcoholic fatty liver disease (NAFLD). The results showed that Irisin concentration was correlated with anthropometric and biochemical parameters, suggesting its potential as a diagnostic biomarker for NAFLD.
Review
Pharmacology & Pharmacy
Siyu Yu, Chunlin Li, Guang Ji, Li Zhang
Summary: Excessive intake of fructose, especially industrial fructose, has been linked to the development of NAFLD by affecting endogenous fructose production, gut barrier, microbiota community, leading to lipid accumulation in the liver and inflammation. Targeting the absorption and metabolism of fructose may be a promising strategy for NAFLD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Sue Shea, Christos Lionis, Chris Kite, Lou Atkinson, Surinderjeet S. Chaggar, Harpal S. Randeva, Ioannis Kyrou
Summary: Non-alcoholic fatty liver disease (NAFLD) is closely associated with metabolic syndrome, and bidirectional links may exist between NAFLD and mental health comorbidity. Positive associations are found between mental health issues (such as depression, anxiety, stress) and NAFLD/metabolic syndrome, highlighting the need for further investigation and intervention.
Article
Nutrition & Dietetics
Yoshito Yabe, Kanako Chihara, Natsumi Oshida, Takashi Kamimaki, Naoyuki Hasegawa, Tomonori Isobe, Junichi Shoda
Summary: The incidence of non-obese non-alcoholic fatty liver disease (NAFLD) is increasing globally. This study investigated the association between non-obese NAFLD, dietary habits, and physical activity levels. The results suggest that low consumption of fish and fish products and high consumption of pickles may be associated with a higher risk of non-obese NAFLD. Dietary habits and physical activity should be considered in the management of non-obese NAFLD patients.
Review
Medicine, Research & Experimental
Shendong Wang, Zhaojun Liu, Jiafeng Geng, Liangge Li, Xiujing Feng
Summary: Non-alcoholic fatty liver disease (NAFLD) is a global public health problem with no specific drug to reverse it. Ferroptosis has been implicated in the progression of NAFLD, although its mechanism of action remains poorly understood.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Amina Basha, Sarah C. C. May, Ryan M. M. Anderson, Niharika Samala, Raghavendra G. G. Mirmira
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease caused by fat accumulation in the liver without excess alcohol use or other liver disease causes. Its complications include cirrhosis, liver failure, hepatocellular carcinoma, and death. The pathophysiology of NAFLD, including insulin resistance and inflammation, remains poorly understood. Animal models have played a crucial role in defining these mechanisms and developing therapies for NAFLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Ludovico Abenavoli, Tiziana Larussa, Alessandro Corea, Anna Caterina Procopio, Luigi Boccuto, Marcello Dallio, Alessandro Federico, Francesco Luzza
Summary: NAFLD, characterized by a wide spectrum of liver disorders, is considered a major public health issue globally. Polyphenols, known for their anti-inflammatory and antioxidant properties, are believed to have potential benefits in preventing and treating NAFLD, though limited human clinical trials are available.
Article
Public, Environmental & Occupational Health
Elaheh Zarean, Mehdi Azizmohammad Looha, Payam Amini, Ali Ahmadi, Pierre-Antoine Dugue
Summary: This study found that individuals with NAFLD had poor sleep quality, shorter sleep duration, increased daytime napping, and higher use of sleeping pills. These associations were particularly strong in middle-aged Iranians.
Article
Nutrition & Dietetics
Aowen Tian, Zewen Sun, Miaoran Zhang, Jiuling Li, Xingchen Pan, Peng Chen
Summary: This study aimed to investigate the relationship between dietary fatty acid composition and non-alcoholic fatty liver disease (NAFLD) in populations with typical diets. It found that a PUFA enriched vegetarian dietary pattern was negatively associated with NAFLD risk, while a PUFA enriched carnivore dietary pattern was not associated with NAFLD risk. The mediation analysis indicated that specific fatty acids had a significant indirect effect on the association between dietary patterns and NAFLD.
FRONTIERS IN NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Maria Magdalena Quetglas-Llabres, Margalida Monserrat-Mesquida, Cristina Bouzas, Isabel Llompart, David Mateos, Miguel Casares, Lucia Ugarriza, J. Alfredo Martinez, Josep A. Tur, Antoni Sureda
Summary: Non-alcoholic fatty liver disease (NAFLD) is characterized by liver fat deposition without alcohol consumption. This study aimed to assess the antioxidant and pro-inflammatory state in NAFLD patients following a 12-month lifestyle intervention based on adherence to a Mediterranean diet (AMD). The intervention resulted in improvements in anthropometric and biochemical parameters, with higher reductions in alanine aminotransferase (ALT) and C reactive protein (CRP) observed in participants with high AMD. Additionally, there were decreases in prooxidant and proinflammatory markers, as well as improvements in physical fitness and intrahepatic fat contents. These improvements were more significant in individuals with higher adherence to the Mediterranean diet.
Article
Nutrition & Dietetics
Shunming Zhang, Yeqing Gu, Shanshan Bian, Magdalena J. Gorska, Qing Zhang, Li Liu, Ge Meng, Zhanxin Yao, Hongmei Wu, Yawen Wang, Tingjing Zhang, Xuena Wang, Shaomei Sun, Xing Wang, Ming Zhou, Qiyu Jia, Kun Song, Lu Qi, Kaijun Niu
Summary: The study found that dietary patterns rich in animal foods or sugar were associated with a higher risk of NAFLD among Chinese adults, whereas a vegetable-rich dietary pattern was not associated.
CLINICAL NUTRITION
(2021)
Article
Public, Environmental & Occupational Health
Yu Zhu, Hu Yang, Yaozong Zhang, Songxian Rao, Yufeng Mo, Honghua Zhang, Shaoxian Liang, Zhuang Zhang, Wanshui Yang
Summary: This study found that a dietary pattern rich in fiber was negatively associated with the risk of non-alcoholic fatty liver disease (NAFLD). Obesity, a known predisposing factor for NAFLD, was found to mediate the association between dietary fiber intake and NAFLD. Increasing dietary fiber intake could be an effective strategy for NAFLD prevention.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Gastroenterology & Hepatology
Yuanyuan Sun, Shuohua Chen, Xinyu Zhao, Yanhong Wang, Yanqi Lan, Xiaozhong Jiang, Xiang Gao, Shouling Wu, Li Wang
Summary: This study found that adherence to the DASH diet is associated with a lower risk of NAFLD in the Chinese population. It is especially beneficial for women, individuals with overweight/obesity, and those with high levels of C-reactive protein.
LIVER INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Yun-Yi Zou, Xiang-bin Tang, Zhang-Lin Chen, Bin Liu, Lan Zheng, Ming-Yang Song, Qin Xiao, Zuo-Qiong Zhou, Xi-Yang Peng, Chang-Fa Tang
Summary: Recent reports suggest that mitochondrial quality decreases during NAFLD progression, and targeting the mitochondria may be a potential treatment for NAFLD. Exercise has been found to effectively slow NAFLD progression or treat NAFLD. However, the effect of exercise on mitochondrial quality in NAFLD has not been established.
FRONTIERS IN ENDOCRINOLOGY
(2023)