Journal
NUTRIENTS
Volume 12, Issue 5, Pages -Publisher
MDPI
DOI: 10.3390/nu12051427
Keywords
allergic rhinitis; probiotics; immunoglobulin E; interleukin-10
Categories
Funding
- Medical Research Program of the National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2017M3A9G2049280]
- Hallym University Research Fund 2017 [HURF-2017-76]
- National Research Foundation of Korea [2017M3A9G2049280] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Although several recent studies reported that probiotics might be beneficial for allergic rhinitis (AR), the effect of probiotics on AR is not consistent and have not been reproduced between studies. We aimed to determine the efficacy and safety of probiotic NVP-1703, a mixture of Bifidobacterium longum and Lactobacillus plantarum, in subjects with perennial AR. Adult subjects with perennial AR received either NVP-1703 (n = 47) or placebo (n = 48) for four weeks. Total nasal symptom scores (TNSS), rhinitis control assessment test (RCAT), blood eosinophil count, allergen-specific IgE, and immunological parameters in serum and urine were compared at baseline and after four weeks. TNSS changes from baseline at weeks 1, 3, and 4 were significant between the NVP-1703 and placebo groups (p = 0.033, 0.031, and 0.029, respectively). RCAT score showed significant differences between the NVP-1703 and placebo groups (p = 0.049) at week 4. Dermatophagoides farinae-specific IgE levels and serum IL-10 levels were significantly different between the NVP-1703 and placebo groups (p = 0.033 and p = 0.047, respectively). IL-10/IL-4 and IL-10/IL-13 ratios were different between the NVP-1703 and placebo groups at week 4 (p = 0.046 and 0.018, respectively). NVP-1703 treatment reduced urinary prostaglandin F-2 alpha and leukotriene E-4 levels (p > 0.05). Therefore, NVP-1703 can be treatment option for perennial AR.
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