Modulation of Cellular Biochemistry, Epigenetics and Metabolomics by Ketone Bodies. Implications of the Ketogenic Diet in the Physiology of the Organism and Pathological States

Prominent action of butyrate over β-hydroxybutyrate as histone deacetylase inhibitor, transcriptional modulator and anti-inflammatory molecule

(2019) Sabrina Chriett et al.   Scientific Reports

p53 β-hydroxybutyrylation attenuates p53 activity

(2019) Kun Liu et al.   Cell Death & Disease

Effects of β-hydroxybutyrate treatment on glycogen repletion and its related signaling cascades in epitrochlearis muscle during 120 min of post-exercise recovery

(2019) Yumiko Takahashi et al.   Applied Physiology Nutrition and Metabolism

Ketogenic diet in the treatment of cancer – Where do we stand?

(2019) Daniela D. Weber et al.   Molecular Metabolism

Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

(2019) Chia-Wei Cheng et al.   CELL

Efficacy and safety of very low calorie ketogenic diet (VLCKD) in patients with overweight and obesity: A systematic review and meta-analysis

(2019) Marco Castellana et al.   REVIEWS IN ENDOCRINE & METABOLIC DISORDERS

The ketogenic diet: Pros and cons

(2019) Blair O'Neill et al.   ATHEROSCLEROSIS

Ketogenesis-generated β-hydroxybutyrate is an epigenetic regulator of CD8+ T-cell memory development

(2019) Huafeng Zhang et al.   NATURE CELL BIOLOGY

Effects of Intermittent Fasting on Health, Aging, and Disease

(2019) Rafael de Cabo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ketogenic diet in cancer therapy

(2018) Daniela D. Weber et al.   Aging-US

Ketone bodies as epigenetic modifiers

(2018) Hai-Bin Ruan et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Treatment with D-β-hydroxybutyrate protects heart from ischemia/reperfusion injury in mice

(2018) Yongsheng Yu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Indispensable Amino Acid–Deficient Diets Induce Seizures in Ketogenic Diet–Fed Rodents, Demonstrating a Role for Amino Acid Balance in Dietary Treatments for Epilepsy

(2018) Dorothy W Gietzen et al.   JOURNAL OF NUTRITION

Impact of Hypoglycemia on Brain Metabolism During Diabetes

(2018) Ashish K. Rehni et al.   MOLECULAR NEUROBIOLOGY

Hypertension and cardiovascular risk: General aspects

(2018) Sverre E. Kjeldsen   PHARMACOLOGICAL RESEARCH

Effects of a medium-chain triglyceride-based ketogenic formula on cognitive function in patients with mild-to-moderate Alzheimer’s disease

(2018) Miho Ota et al.   NEUROSCIENCE LETTERS

Salt-Responsive Metabolite, β-Hydroxybutyrate, Attenuates Hypertension

(2018) Saroj Chakraborty et al.   Cell Reports

The Ketone Metabolite β-Hydroxybutyrate Attenuates Oxidative Stress in Spinal Cord Injury by Suppression of Class I Histone Deacetylases

(2017) Ganggang Kong et al.   JOURNAL OF NEUROTRAUMA

Beneficial effects of ketogenic diets for cancer patients: a realist review with focus on evidence and confirmation

(2017) Rainer J. Klement   MEDICAL ONCOLOGY

A ketogenic diet supplemented with medium-chain triglycerides enhances the anti-tumor and anti-angiogenic efficacy of chemotherapy on neuroblastoma xenografts in a CD1-nu mouse model

(2017) Sepideh Aminzadeh-Gohari et al.   Oncotarget

The Warburg effect as an adaptation of cancer cells to rapid fluctuations in energy demand

(2017) Tamir Epstein et al.   PLoS One

A randomized controlled trial of the ketogenic diet in refractory childhood epilepsy

(2016) D. A. J. E. Lambrechts et al.   ACTA NEUROLOGICA SCANDINAVICA

Nutritional Ketosis Alters Fuel Preference and Thereby Endurance Performance in Athletes

(2016) Pete J. Cox et al.   Cell Metabolism

Metabolism of ketone bodies during exercise and training: physiological basis for exogenous supplementation

(2016) Mark Evans et al.   JOURNAL OF PHYSIOLOGY-LONDON

Metabolic characteristics of keto-adapted ultra-endurance runners

(2016) Jeff S. Volek et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation

(2016) Zhongyu Xie et al.   MOLECULAR CELL

β-Hydroxybutyrate in the Brain: One Molecule, Multiple Mechanisms

(2016) Lavanya B. Achanta et al.   NEUROCHEMICAL RESEARCH

Biosensor reveals multiple sources for mitochondrial NAD+

(2016) X. A. Cambronne et al.   SCIENCE

Metabolic Regulation of Histone Post-Translational Modifications

(2015) Jing Fan et al.   ACS Chemical Biology

Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury

(2015) Rebecca J Godar et al.   Autophagy

Ketogenic Diets for Fat Loss and Exercise Performance

(2015) Bente Kiens et al.   EXERCISE AND SPORT SCIENCES REVIEWS

High Salt Intake Increases Blood Pressure in Normal Rats: Putative Role of 20-HETE and No Evidence on Changes in Renal Vascular Reactivity

(2015) A. Walkowska et al.   KIDNEY & BLOOD PRESSURE RESEARCH

Ketogenic diet prevents epileptogenesis and disease progression in adult mice and rats

(2015) Theresa A. Lusardi et al.   NEUROPHARMACOLOGY

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Ketone body therapy: from the ketogenic diet to the oral administration of ketone ester

(2014) Sami A. Hashim et al.   JOURNAL OF LIPID RESEARCH

BHBA Suppresses LPS-Induced Inflammation in BV-2 Cells by Inhibiting NF-κB Activation

(2014) Shou-Peng Fu et al.   MEDIATORS OF INFLAMMATION

Do ketogenic diets really suppress appetite? A systematic review and meta-analysis

(2014) A. A. Gibson et al.   Obesity Reviews

The Effects of a Ketogenic Diet on Exercise Metabolism and Physical Performance in Off-Road Cyclists

(2014) Adam Zajac et al.   Nutrients

Role of β-hydroxybutyrate, its polymer poly-β-hydroxybutyrate and inorganic polyphosphate in mammalian health and disease

(2014) Elena N. Dedkova et al.   Frontiers in Physiology

Deep sequencing reveals increased DNA methylation in chronic rat epilepsy

(2013) Katja Kobow et al.   ACTA NEUROPATHOLOGICA

Role of polyhydroxybutyrate in mitochondrial calcium uptake

(2013) Matthew Smithen et al.   CELL CALCIUM

Ketogenic Diet Improves Motor Performance but Not Cognition in Two Mouse Models of Alzheimer’s Pathology

(2013) Milene L. Brownlow et al.   PLoS One

Polyhydroxybutyrate Targets Mammalian Mitochondria and Increases Permeability of Plasmalemmal and Mitochondrial Membranes

(2013) Pia A. Elustondo et al.   PLoS One

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

(2012) Yoshihiro Kashiwaya et al.   NEUROBIOLOGY OF AGING

Influence of Threonine Metabolism on S-Adenosylmethionine and Histone Methylation

(2012) N. Shyh-Chang et al.   SCIENCE

Suppression of Oxidative Stress by  -Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

(2012) T. Shimazu et al.   SCIENCE

Brain aging, Alzheimer's disease, and mitochondria

(2011) Russell H. Swerdlow   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Cancer cells metabolically "fertilize" the tumor microenvironment with hydrogen peroxide, driving the Warburg effect

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

A ketogenic diet suppresses seizures in mice through adenosine A1 receptors

(2011) Susan A. Masino et al.   JOURNAL OF CLINICAL INVESTIGATION

Long-term outcome and tolerability of the ketogenic diet in drug-resistant childhood epilepsy—The Austrian experience

(2010) Anastasia Dressler et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Study of the ketogenic agent AC-1202 in mild to moderate Alzheimer's disease: a randomized, double-blind, placebo-controlled, multicenter trial

(2009) Samuel T Henderson et al.   Nutrition & Metabolism

Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies

(2008) Andrew G Renehan et al.   LANCET

The ketogenic diet for the treatment of childhood epilepsy: a randomised controlled trial

(2008) Elizabeth G Neal et al.   LANCET NEUROLOGY