Article
Materials Science, Biomaterials
Gigliola Lusvardi, Francesca Fraulini, Sergio D'Addato, Alfonso Zambon
Summary: This study evaluated a series of cerium-doped bioactive glasses loaded with different biomolecules. The results showed that MBGs loaded with POLY had the highest loading and exhibited stronger catalase-like activity and superoxide anion-like activity.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Pharmacology & Pharmacy
Hanyu Xie, Sha Sha, Lingbo Lu, Geng Wu, Hongbing Jiang, Aldo R. Boccaccini, Kai Zheng, Rongyao Xu
Summary: This study found that cerium-containing mesoporous bioactive glass nanoparticles can stimulate lymphangiogenesis, promote the proliferation and migration of lymphatic endothelial cells, and facilitate the formation of lymphatic vascular networks.
Article
Materials Science, Multidisciplinary
Haoyu Li, Zongliang Wang, Qingxu Song, Min Guo, Zixue Jiao, Yu Wang, Yi Liu, Yongzhan Zhu, Peibiao Zhang
Summary: In this study, CeO2NPs/PEEK microspheres were prepared by introducing cerium (IV) sulfate into PEEK and converting it to cerium dioxide nanoparticles through hydrolysis and hydrothermal treatment. The CeO2NPs in the microspheres exhibited catalase-like activity and reduced hydrogen peroxide in the bone injury micro-environment. The CeO2NPs/PEEK microspheres promoted cell proliferation, osteogenic differentiation, and showed excellent bone regeneration in a rat-skull-defect repair model.
MATERIALS & DESIGN
(2023)
Review
Engineering, Biomedical
Kai Zheng, Wen Niu, Bo Lei, Aldo R. Boccaccini
Summary: The regulatory functions of immune response in tissue regeneration, ways to modulate immune cell responses (especially macrophages), and the potential of bioactive glasses in bone regeneration and wound healing have been recognized. Understanding the immunomodulatory effects of BGs and the interactions with immune cells are crucial for enhancing tissue regeneration. Emerging research focuses on harnessing macrophage responses through active ions, surface functionalization, and controlled release of immunomodulatory agents for improved tissue regeneration.
ACTA BIOMATERIALIA
(2021)
Article
Engineering, Biomedical
M. Vallet-Regi, A. J. Salinas
Summary: Mesoporous bioactive glasses (MBGs) play an important role in bone regeneration with their outstanding textural properties, quick bioactive responses, and biocompatibility. They can be enhanced by adding small amounts of oxide elements to provide additional biological capacities. MBGs are versatile in various forms and can be further improved by loading with biomolecules, drugs, and stem cells.
MATERIALS TODAY BIO
(2021)
Article
Materials Science, Multidisciplinary
Sara Ferraris, Ingrid Corazzari, Francesco Turci, Andrea Cochis, Lia Rimondini, Silvia Spriano, Jonathan Massera, Enrica Verne
Summary: In this study, silicate and borosilicate bioactive glasses were synthesized and characterized. The antioxidant activity of the glasses was correlated to their surface properties, and it was found that boron enhanced glass reactivity while strontium and magnesium played a stabilizing role. The glasses were also found to have a scavenging potential against reactive oxygen species, and they exhibited a protective effect on viable cells.
ADVANCED ENGINEERING MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Mengzhen Zhang, Xinyun Zhai, Tengfei Ma, Yongkang Huang, Mengdie Jin, Houzhi Yang, Hao Fu, Shuai Zhang, Tianwei Sun, Xin Jin, Yaping Du, Chun-Hua Yan
Summary: In this study, cerium oxide nanoparticles (CeO2 NPs) were successfully integrated into bioactive glass (BG) to fabricate three-dimensional (3D)-printed scaffolds, which exhibited sequential therapeutic effects against inflammation and promotion of osteogenesis in bone defects. The antioxidative activity of CeO2 NPs played a crucial role in relieving oxidative stress and promoting bone formation. Furthermore, CeO2 NPs promoted the proliferation and osteogenic differentiation of rat osteoblasts, leading to enhanced mineral deposition and osteogenic gene expression. The incorporation of CeO2 NPs provided the BG scaffolds with reinforced mechanical properties, improved biocompatibility, cell adhesion, elevated osteogenic capability, and multifunctional performance. In vivo studies confirmed the superior osteogenic properties of CeO2-BG scaffolds compared to pure BG scaffolds in the treatment of rat tibial defects. The 3D printing technique also created a suitable porous microenvironment for cell ingrowth and new bone formation around the bone defect. Overall, this study demonstrates the potential of CeO2-BG 3D-printed scaffolds for sequential and integral treatment in bone tissue engineering.
Article
Nanoscience & Nanotechnology
Yuemei Li, Yongmei Li, Haoming Wang, Riyue Liu
Summary: Yb/Er/CeO2-x upconversion nanoparticles have shown promising antioxidative activities in the treatment of Parkinson's disease, with increased enzyme-like catalytic activities and reductions in ROS production in the brain, indicating their potential as a therapeutic option for PD.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Engineering, Biomedical
Stefano Raimondi, Alfonso Zambon, Raffaella Ranieri, Francesca Fraulini, Alberto Amaretti, Maddalena Rossi, Gigliola Lusvardi
Summary: Cerium-doped bioactive glasses have high biocompatibility, antimicrobial activity, and the potential to regulate environmental pH; the presence of cerium not only reduces E. coli charge, but also accelerates the increase of pH in the medium, contributing to the antibacterial effect.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2021)
Review
Pharmacology & Pharmacy
Maria Vallet-Regi, Montserrat Colilla, Isabel Izquierdo-Barba, Chiara Vitale-Brovarone, Sonia Fiorilli
Summary: Mesoporous bioactive glasses (MBGs) are highly promising candidates in the field of bioceramics for bone tissue regeneration, thanks to their unique chemical composition, structural and surface properties. Recent research has focused on optimizing the texture and structure of MBGs and exploring their potential as multitherapy systems, particularly in the context of local drug delivery. This article provides an overview of the latest developments in MBGs for bone tissue engineering, multifunctionalization, and drug delivery, as well as discussing the current challenges and future directions for clinical translation of MBGs.
Article
Biophysics
Maksym Moskvin, Veronika Huntosova, Vit Herynek, Petr Matous, Alena Michalcova, Volodymyr Lobaz, Beata Zasonska, Miroslav Slouf, Robert Seliga, Daniel Horak
Summary: The study obtained magnetic gamma-Fe2O3/CeO2 nanoparticles by precipitation of Ce(NO3)3 with ammonia in the presence of gamma-Fe2O3 seeds. The CeO2 nanoparticles formed on the seeds were functionalized with PEGneridronate for improved colloidal stability and biocompatibility, resulting in concentration-dependent cytotoxicity.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Cristina Chircov, Maria-Andreea Minca, Andreea Bianca Serban, Alexandra Catalina Birca, Georgiana Dolete, Vladimir-Lucian Ene, Ecaterina Andronescu, Alina-Maria Holban
Summary: This study aimed to develop zinc and/or cerium-substituted magnetite nanoparticles for medical applications. The nanostructures were evaluated using various analysis methods and subjected to antioxidant, anticancer, and antimicrobial tests. The results showed promising effects, including the inhibition of oxidative stress in normal cells, inhibition of cell proliferation in tumor cells, and antimicrobial activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Francesca Corsi, Greta Deidda Tarquini, Marta Urbani, Ignacio Bejarano, Enrico Traversa, Lina Ghibelli
Summary: Cerium oxide nanoparticles (CNPs) are biocompatible nanozymes with multifunctional biomimetic activities, including anti-inflammatory effects. CNPs have the ability to scavenge reactive oxygen species and boost anti-inflammatory signaling pathways, effectively combating chronic inflammation, infections, and trauma, and improving/restoring organ function. The exact mechanism of CNPs' anti-inflammatory effects is still not fully understood, but it is suggested that the pleiotropic actions of CNPs, including their phosphatase activity, may play a role.
Article
Nanoscience & Nanotechnology
Feng Li, Jian Li, Xujun Song, Tong Sun, Lian Mi, Jian Liu, Xiaomin Xia, Na Bai, Xue Li
Summary: This study developed and evaluated an appropriate GA-nCeO2 hydrogel scaffold for bone tissue engineering. The results showed that the scaffold had a favorable structure, biocompatibility, and strong osteogenic potential. This research provides a potential new material for the treatment of bone defects.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Chemistry, Multidisciplinary
Endian Wang, Xinfang Li, Yu Zhang, Lingling Ma, Qing Xu, Yuanzheng Yue, Wenzhong Wang, Qin Li, Jianding Yu, Jiang Chang
Summary: Black CaO-SiO2-TiO2 (CST) glasses prepared through containerless melting exhibit multi-functional properties including inhibiting bacteria and tumors, promoting angiogenesis, and accelerating chronic wound healing. These glasses are promising materials for tissue regeneration in complex lesions.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Physical
Valeria Cannillo, Roberta Salvatori, Stefania Bergamini, Devis Bellucci, Carlo Bertoldi
Summary: This review focuses on the applications of bioactive glasses in periodontal regeneration. Although there are numerous in vitro tests, only a few studies have been conducted on in vivo research and clinical trials. Nonetheless, bioactive glasses appear to be a suitable choice for grafts in periodontal regeneration.
Article
Biochemistry & Molecular Biology
Debora Carrozza, Gianluca Malavasi, Erika Ferrari, Maria Cristina Menziani
Summary: Cancer is a major cause of death worldwide, and abnormal cancer homeostasis is caused by homeostatic errors and reactive oxygen species. Curcumin, with its versatile properties, could be a potential candidate for cancer treatment. However, its poor oral bioavailability is a major concern, which can be addressed by encapsulating it into small particles such as hydrogel beads containing mesoporous silica. This study synthesized various systems and demonstrated their effectiveness in stabilizing and delivering curcumin. The combination of cerium and curcumin showed a synergistic effect in promoting enzymatic-like activity. These systems have the potential to be used as drug delivery systems for targeted curcumin dosing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Biomedical
A. Anesi, M. Ferretti, R. Salvatori, D. Bellucci, F. Cavani, M. Di Bartolomeo, C. Palumbo, V. Cannillo
Summary: Bioactive glasses (BGs) have shown great potential as materials for tissue regeneration, and two new BGs, BGMS10 and Bio_MS, demonstrated promising results in animal implantation tests. These BGs, containing therapeutic ions, were found to be biocompatible and capable of promoting the formation of uniformly distributed bone trabeculae in the implanted site. In contrast, the comparison standard 45S5 Bioglass (R) showed less uniform and coarse trabeculae, separated by soft tissue. Therefore, BGMS10 and Bio_MS could be considered suitable for tissue regeneration in orthopedic and dental fields.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Chemistry, Physical
Debora Carrozza, Gianluca Malavasi, Erika Ferrari
Summary: The synthesis of silica particles with large pores (LPMS) is important for accommodating big molecules with a pharmaceutical role and maintaining their biological activity. LPMSs showed better loading and releasing properties compared to classical mesoporous silica (MS). LPMSs exhibited a significantly higher loading efficiency and a controlled release in simulated body fluid, while MS experienced pore blocking. LPMSs maintained their structure and demonstrated strength and mechanical resistance.
Article
Chemistry, Multidisciplinary
Mattia Di Bartolomeo, Arrigo Pellacani, Federico Bolelli, Marco Cipriano, Luca Lumetti, Sara Negrello, Stefano Allegretti, Paolo Minafra, Federico Pollastri, Riccardo Nocini, Giacomo Colletti, Luigi Chiarini, Costantino Grana, Alexandre Anesi
Summary: Convolutional neural networks have been used to accurately identify the Inferior Alveolar Canal (IAC) and quickly generate precise 3D data. The datasets and source code used in this study are publicly available, allowing for reproducibility of the experiments. The lack of accessible datasets and open-source algorithms has been hindering advancements in this field.
APPLIED SCIENCES-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Alessia Giordana, Mery Malandrino, Alfonso Zambon, Gigliola Lusvardi, Lorenza Operti, Giuseppina Cerrato
Summary: We created nanohybrids using humic and fulvic acids from digestate for potential use in agronomy. To achieve a simultaneous release of beneficial substances for plants, we modified hydroxyapatite (HP) and silica (SiO2) nanoparticles with humic substances. SiO2 NPs obtained from rice husks have limited capacity to absorb humic substances, while HP NPs coated with fulvic acid demonstrate promising results based on desorption and dilution studies. The different dissolutions observed for fulvic and humic acid coated HP NPs could be attributed to their different interaction mechanisms as indicated by the FT-IR study.
FRONTIERS IN CHEMISTRY
(2023)
Review
Health Care Sciences & Services
Giacomo Colletti, Mattia Di Bartolomeo, Sara Negrello, Roy G. Geronemus, Bernard Cohen, Luigi Chiarini, Alexandre Anesi, Raimondo Femino, Ilaria Mariotti, Gregory M. Levitin, Linda Rozell-Shannon, Riccardo Nocini
Summary: This systematic review explores the potential effects of multiple general anesthesia (mGA) procedures on neurodevelopment in patients under 4 years old. The study found that children receiving mGA may be at a greater risk of neurodevelopmental delay. A total of 264,759 unexposed children and 11,027 exposed children were assessed, with significant differences in neurodevelopmental outcomes. Therefore, careful risk/benefit considerations are needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Engineering, Biomedical
Francesca Fraulini, Stefano Raimondi, Francesco Candeliere, Raffaella Ranieri, Alfonso Zambon, Gigliola Lusvardi
Summary: Mesoporous bioactive glasses (MBGs) have been widely used in tissue engineering for hard tissue regeneration. In order to develop biomaterials with antibiotic properties, cerium-doped MBGs were investigated as controlled drug delivery systems (DDSs) for gentamicin (Gen), a wide spectrum antibiotic commonly used against postoperative infections. The results showed that the optimized Gen-loaded cerium-doped MBGs retained significant bioactivity, antioxidant properties, and exhibited antibacterial efficacy for up to 10 days of controlled release. These findings make Gen-loaded cerium-doped MBGs promising candidates for simultaneous hard tissue regeneration and in situ antibiotic release.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Review
Health Care Sciences & Services
Giacomo Colletti, Sara Negrello, Linda Rozell-Shannon, Gregory M. M. Levitin, Liliana Colletti, Luigi Chiarini, Alexandre Anesi, Mattia Di Bartolomeo, Arrigo Pellacani, Riccardo Nocini
Summary: This study evaluated the role of surgery in treating port-wine stains and found that surgery is effective for cases that do not respond to laser therapy or have tissue hypertrophy. Surgery can be used to correct facial asymmetry related to port-wine stains and achieve a more harmonious and predictable result.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Surgery
Adewale Adisa
Summary: This study aims to prioritize feasible interventions to reduce the environmental impact of operating theatres. Through a four-phase Delphi consensus methodology, the results suggest that actionable interventions applicable to both high- and low-middle-income countries can be taken to achieve environmentally sustainable operating environments.
BRITISH JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Mattia Di Bartolomeo, Irene Laura Lusetti, Massimo Pinelli, Sara Negrello, Arrigo Pellacani, Stefano Angelini, Luigi Chiarini, Riccardo Nocini, Giorgio De Santis, Alexandre Anesi
Summary: This study investigated the effects of volume, length, and number of fibula flap segments on flap survival and analyzed other potential risk factors. The results indicated that volume, length, and number of segments did not seem to affect flap failure rate, while reconstruction of the maxilla and use of a recipient vessel different from the facial artery significantly impacted flap failure. Smoking and previous surgeries showed a higher trend towards flap failure but did not reach statistical significance.
Article
Medicine, General & Internal
Martina Buchignani, Arrigo Pellacani, Sara Negrello, Mattia Di Bartolomeo, Monica Cellini, Alessia Pancaldi, Alessandra Buttafoco, Camilla Migliozzi, Lorenzo Iughetti, Luigi Chiarini, Alexandre Anesi
Summary: Pediatric sarcomas, particularly Rhabdomyosarcoma (RMS) and Non-Rhabdomyosarcoma Type Sarcomas (STSNR), are rare malignancies accounting for about 10% of solid tumors in childhood. The treatment of pediatric sarcomas is challenging and typically involves a multidisciplinary approach including chemotherapy, surgery, and radiotherapy. Managing the long-term effects of treatment is crucial in maintaining a good quality of life (QoL) for affected patients.
Review
Medicine, General & Internal
Sara Negrello, Arrigo Pellacani, Mattia Di Bartolomeo, Giuseppe Pollastri, Alexandre Anesi
Summary: Bone xanthoma is a rare benign primary bone lesion characterized by foamy cells with fat droplets. It is usually associated with endocrine or metabolic diseases, but primary xanthoma occurs in the absence of these diseases. Due to the lack of specific radiologic and clinical features, a differential diagnosis is needed to distinguish it from potentially malignant lesions. We present a case of primary mandibular xanthoma in a 16-year-old girl, without typical skin manifestations or lipid value alterations. The involvement of the temporomandibular joint at the mandibular condyle is peculiar in this case. We also provide a qualitative systematic review of literature on primary xanthoma of the jaws to establish treatment guidelines.
Article
Dentistry, Oral Surgery & Medicine
Mattia Di Bartolomeo, Alexandre Anesi, Arrigo Pellacani, Sara Negrello, Annalisa Natale, Sabina Figurelli, Doriana Vaddinelli, Stefano Angelini, Luigi Chiarini, Riccardo Nocini, Paolo Di Bartolomeo
Summary: The aim of this retrospective study was to determine the incidence and clinical outcome of tongue cancer in Fanconi anemia patients who had received an allogeneic hematopoietic cell transplantation. The study revealed a high incidence of tongue cancer in these patients, and the tumors showed aggressive behavior. The results underscore the importance of lifelong screening for these patients.
CLINICAL ORAL INVESTIGATIONS
(2022)
