4.6 Article

Graphene Oxide Carboxymethylcellulose Nanocomposite for Dressing Materials

Journal

MATERIALS
Volume 13, Issue 8, Pages -

Publisher

MDPI
DOI: 10.3390/ma13081980

Keywords

graphene oxide nanocomposite; carboxymethyl cellulose; biocompatibility; medical devices

Funding

  1. University of Palermo [FFR-D15-16024, FFR-D15-180463, CORI-2018-C-D15-180463]
  2. Statutory Funds of the Wroclaw Medical University

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Sore, infected wounds are a major clinical issue, and there is thus an urgent need for novel biomaterials as multifunctional constituents for dressings. A set of biocomposites was prepared by solvent casting using different concentrations of carboxymethylcellulose (CMC) and exfoliated graphene oxide (Exf-GO) as a filler. Exf-GO was first obtained by the strong oxidation and exfoliation of graphite. The structural, morphological and mechanical properties of the composites (CMCx/Exf-GO) were evaluated, and the obtained composites were homogenous, transparent and brownish in color. The results confirmed that Exf-GO may be homogeneously dispersed in CMC. It was found that the composite has an inhibitory activity against the Gram-positive Staphylococcus aureus, but not against Gram-negative Pseudomonas aeruginosa. At the same time, it does not exhibit any cytotoxic effect on normal fibroblasts.

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