Oncogenic MicroRNAs Biogenesis as a Drug Target: Structure-Activity Relationship Studies on New Aminoglycoside Conjugates

Small molecule compounds targeting miRNAs for cancer therapy

(2015) Paloma del C. Monroig et al.   ADVANCED DRUG DELIVERY REVIEWS

Ribosome-targeting antibiotics as inhibitors of oncogenic microRNAs biogenesis: Old scaffolds for new perspectives in RNA targeting

(2015) Thi Phuong Anh Tran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nonconventional chemical inhibitors of microRNA: therapeutic scope

(2015) Gopal Gunanathan Jayaraj et al.   CHEMICAL COMMUNICATIONS

Small molecule chemical probes of microRNA function

(2015) Sai Pradeep Velagapudi et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Inhibition of Gastric Tumor Cell Growth Using Seed-targeting LNA as Specific, Long-lasting MicroRNA Inhibitors

(2015) Cathy Staedel et al.   Molecular Therapy-Nucleic Acids

Two-dimensional combinatorial screening enables the bottom-up design of a microRNA-10b inhibitor

(2014) Sai Pradeep Velagapudi et al.   CHEMICAL COMMUNICATIONS

Development of microRNA therapeutics is coming of age

(2014) E. van Rooij et al.   EMBO Molecular Medicine

Sequence-based design of bioactive small molecules that target precursor microRNAs

(2014) Sai Pradeep Velagapudi et al.   Nature Chemical Biology

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting the Production of Oncogenic MicroRNAs with Multimodal Synthetic Small Molecules

(2013) Duc Duy Vo et al.   ACS Chemical Biology

Treatment of HCV Infection by Targeting MicroRNA

(2013) Harry L.A. Janssen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Helicobacter pylori Initiates a Mesenchymal Transition through ZEB1 in Gastric Epithelial Cells

(2013) Jessica Baud et al.   PLoS One

Neomycin–phenolic conjugates: Polycationic amphiphiles with broad-spectrum antibacterial activity, low hemolytic activity and weak serum protein binding

(2012) Brandon Findlay et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

microRNA involvement in human cancer

(2012) M. V. Iorio et al.   CARCINOGENESIS

Selectively Guanidinylated Aminoglycosides as Antibiotics

(2012) Richard J. Fair et al.   ChemMedChem

Molecular Pathways: MicroRNAs as Cancer Therapeutics

(2012) S. A. Melo et al.   CLINICAL CANCER RESEARCH

The Tuberculosis Drug Streptomycin as a Potential Cancer Therapeutic: Inhibition of miR-21 Function by Directly Targeting Its Precursor

(2011) Debojit Bose et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pre-microRNA binding aminoglycosides and antitumor drugs as inhibitors of Dicer catalyzed microRNA processing

(2011) Mohitosh Maiti et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dicer recognizes the 5′ end of RNA for efficient and accurate processing

(2011) Jong-Eun Park et al.   NATURE

The Role of Flexibility in the Rational Design of Modularly Assembled Ligands Targeting the RNAs that Cause the Myotonic Dystrophies

(2010) Matthew D. Disney et al.   CHEMBIOCHEM

Small Molecule Modifiers of MicroRNA miR-122 Function for the Treatment of Hepatitis C Virus Infection and Hepatocellular Carcinoma

(2010) Douglas D. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Short and Efficient Synthesis of Alkyne-Modified Amino Glycoside Building Blocks

(2009) Claudine M. Klemm et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

miR-372 regulates cell cycle and apoptosis of ags human gastric cancer cell line through direct regulation of LATS2

(2009) Wha Ja Cho et al.   MOLECULES AND CELLS

Biogenesis of small RNAs in animals

(2009) V. Narry Kim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells

(2009) Nalinie S. Wickramasinghe et al.   NUCLEIC ACIDS RESEARCH

Estradiol-regulated microRNAs control estradiol response in breast cancer cells

(2009) Poornima Bhat-Nakshatri et al.   NUCLEIC ACIDS RESEARCH

Small-Molecule Inhibitors of MicroRNA miR-21 Function

(2008) Kiranmai Gumireddy et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emerging Role of miR-106b-25/miR-17-92 Clusters in the Control of Transforming Growth Factor   Signaling

(2008) F. Petrocca et al.   CANCER RESEARCH

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

The evolution of our thinking about microRNAs

(2008) Victor Ambros   NATURE MEDICINE

A fluorescence probe for assaying micro RNA maturation

(2007) Brian P. Davies et al.   BIOORGANIC & MEDICINAL CHEMISTRY