In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis

Computational, crystallographic studies, cytotoxicity and anti-tubercular activity of substituted 7-methoxy-indolizine analogues

(2019) Katharigatta Narayanaswamy Venugopala et al.   PLoS One

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors

(2018) Lijun Song et al.   JOURNAL OF MEDICINAL CHEMISTRY

Three-component reaction of β-keto esters, aromatic aldehydes and urea/thiourea promoted by caffeine, a green and natural, biodegradable catalyst for eco-safe Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones derivatives under solvent-free conditions

(2018) Farzaneh Mohamadpour et al.   JOURNAL OF THE SERBIAN CHEMICAL SOCIETY

Efficient synthesis and characterization of novel indolizines: exploration of in vitro COX-2 inhibitory activity and molecular modelling studies

(2018) Sandeep Chandrashekharappa et al.   NEW JOURNAL OF CHEMISTRY

Unknown

(2018)   ChemMedChem

Synthesis and Structural Elucidation of Novel Benzothiazole Derivatives as Anti-tubercular Agents: In-silico Screening for Possible Target Identification

(2018) Katharigatta N. Venugopala et al.   Medicinal Chemistry

Synthesis, antituberculosis studies and biological evaluation of new quinoline derivatives carrying 1,2,4-oxadiazole moiety

(2018) T.G. Shruthi et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Unknown

(2018)   Chemical Biology & Drug Design

Molecular modeling studies and anti-TB activity of trisubstituted indolizine analogues; molecular docking and dynamic inputs

(2017) Mohammed A. Khedr et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Roles of Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Anticancer Agents

(2017) Supaluk Prachayasittikul et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Prevalence and Molecular Characterization of Second-Line Drugs Resistance among Multidrug-Resistant Mycobacterium tuberculosis Isolates in Southwest of China

(2017) Y. Hu et al.   Biomed Research International

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Dihydropyrimidones: As novel class of β-glucuronidase inhibitors

(2016) Farman Ali et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of C-5 modified 2′-deoxyuridine monophosphates as inhibitors of M. tuberculosis thymidylate synthase

(2015) Liudmila A. Alexandrova et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Unknown

(2015)   JOURNAL OF INTERNAL MEDICINE

Timing is everything for compassionate use of delamanid

(2015) Clifton E Barry   NATURE MEDICINE

Antibacterial Inhibitors of Gram-Positive Thymidylate Kinase: Structure–Activity Relationships and Chiral Preference of a New Hydrophobic Binding Region

(2014) Sameer P. Kawatkar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors

(2014) Maruti Naik et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimosquito Properties of 2-Substituted Phenyl/benzylamino-6-(4- chlorophenyl)-5-methoxycarbonyl-4-methyl-3,6-dihydropyrimidin-1-ium Chlorides Against Anopheles arabiensis

(2014) Venugopala Narayanaswamy et al.   Medicinal Chemistry

FDA Approval of Bedaquiline — The Benefit–Risk Balance for Drug-Resistant Tuberculosis

(2014) Edward Cox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of Mycobacterium tuberculosis strains H37Rv and MDR MS-115 by a new set of C5 modified pyrimidine nucleosides

(2013) Eduard R. Shmalenyuk et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of 5′-modified thymidines and 5-hydroxymethyl-2′-deoxyuridines as Mycobacterium tuberculosis thymidylate kinase inhibitors

(2012) Kiran S. Toti et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Antitubercular Activity of 2-(substituted phenyl/benzyl-amino)-6-(4-chlorophenyl)-5-(methoxycarbonyl)-4-methyl-3,6-dihydropyrimidin-1-ium Chlorides

(2012) Venugopala K. Narayanaswamy et al.   Chemical Biology & Drug Design

Discovery of Selective and Potent Inhibitors of Gram-Positive Bacterial Thymidylate Kinase (TMK)

(2012) Gabriel Martínez-Botella et al.   JOURNAL OF MEDICINAL CHEMISTRY

Microwave-Assisted and Iodine-Catalyzed Synthesis of Dihydropyrimidin-2-thiones via Biginelli Reaction Under Solvent-Free Conditions

(2012) Qingjian Liu et al.   SYNTHETIC COMMUNICATIONS

Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase

(2011) Sara Van Poecke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis, antimicrobial, and mosquito larvicidal activity of 1-aryl-4-methyl-3,6-bis-(5-methylisoxazol-3-yl)-2-thioxo-2,3,6,10b-tetrahydro-1H-pyrimido[5,4-c]quinolin-5-ones

(2010) E. Rajanarendar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Insights into conformational and packing features in a series of aryl substituted ethyl-6-methyl-4-phenyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates

(2010) Susanta K. Nayak et al.   CRYSTENGCOMM

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone

(2010) Olga Familiar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Best drug treatment for multidrug-resistant and extensively drug-resistant tuberculosis

(2010) José A Caminero et al.   LANCET INFECTIOUS DISEASES

Substituted benzyl-pyrimidines targeting thymidine monophosphate kinase of Mycobacterium tuberculosis: Synthesis and in vitro anti-mycobacterial activity

(2008) Cécile Gasse et al.   BIOORGANIC & MEDICINAL CHEMISTRY

C-Furyl glycosides, II: synthesis and antimicrobial evaluation of C-furyl glycosides bearing pyrazolines, isoxazolines, and 5,6-dihydropyrimidine-2(1H)-thiones

(2008) Wael A. El-Sayed et al.   MONATSHEFTE FUR CHEMIE