Article
Chemistry, Applied
Loveleen Kaur Gulati, Gurleen Kaur Gulati, Satish Kumar
Summary: This article discusses the use of photochromism in photodynamic therapy, highlighting the potential of photochromic substances in three different roles to enhance efficacy: as photosensitizers, switches to conventional photosensitizers, and reserves of singlet oxygen.
Article
Chemistry, Multidisciplinary
Feng Xu, Haoying Ge, Ning Xu, Cheng Yang, Qichao Yao, Saran Long, Wen Sun, Jiangli Fan, Xinsheng Xu, Xiaojun Peng
Summary: In this study, a quartet photosensitizer Cy-DENT with high singlet oxygen quantum yield was reported, achieved through a radical enhanced inter-system crossing process. By introducing a TEMPO radical, over 20-fold enhancement of singlet oxygen quantum yield compared to Cy-DEN could be achieved under near infrared light irradiation. The electron-donating ability of the terminal substituent group can effectively control the production of singlet oxygen.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Applied
Ruth Prieto-Montero, Alejandro Prieto-Castaneda, Alberto Katsumiti, Rebeca Sola-Llano, Antonia R. Agarrabeitia, Miren P. Cajaraville, Maria J. Ortiz, Virginia Martinez-Martinez
Summary: Three different molecular designs based on BODIPY dye have been proposed as photosensitizers for photodynamic therapy, showing a good balance between singlet oxygen generation and fluorescence for potential applications. In vitro experiments in HeLa cells were conducted to elucidate the best potential candidate for PDT.
Article
Chemistry, Inorganic & Nuclear
Halise Yalazan, Ipek Omeroglu, Gonca celik, Halit Kantekin, Mahmut Durmus
Summary: This study examines the photophysical and photochemical properties of silicon and zinc phthalocyanines. Different phthalocyanine compounds were synthesized and characterized to study their concentration and solvent effects. The effects of the metal ion and the position of the substituted group on photodynamic therapy properties were also investigated. The results show that the fluorinated pyrazoline-linked axial silicon phthalocyanine (HY-SiPc) has the highest singlet oxygen production and can be a potential photosensitizer for PDT.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Multidisciplinary
Xiaolong Hu, Shuna Wang, Qinghua Luo, Binghui Ge, Qin Cheng, Chen Dong, Jiahui Xu, Haizhen Ding, Mingsheng Xu, Antonio Claudio Tedesco, Xin Huang, Renquan Zhang, Hong Bi
Summary: A new core-shell structured Sn nanocluster@carbon dots photosensitizer with high O-1(2) quantum yield and fluorescence intensity is proposed. Upon light irradiation, this photosensitizer can effectively reduce cancer cell viability, with minimal impact on healthy cells and liver tissue.
CHINESE CHEMICAL LETTERS
(2021)
Article
Chemistry, Physical
Fangyu Jin, Shiqin Liao, Qingqing Wang, Huiying Shen, Chenyu Jiang, Jiawen Zhang, Qufu Wei, Reza A. Ghiladi
Summary: In this study, a scalable and facile method to immobilize long persistent phosphor and photosensitizer onto cotton fabric was reported. The resulting composite material exhibited superior antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureus under visible-light illumination. Mechanistic studies showed enhanced singlet oxygen production, resulting in effective pathogen inactivation. In addition, the composite fabric possessed excellent abrasion resistance, mechanical strength, and color fastness. These findings suggest the potential of using long persistent phosphors in composite fabrics for infection control applications.
APPLIED SURFACE SCIENCE
(2022)
Article
Spectroscopy
Jin Bai, Lei Zhang, Ying Qian
Summary: In this study, a novel NIR and lysosomal targeting thiophene-BODIPY photosensitizer SBOP-Lyso was synthesized to explore its potential applications in photodynamic therapy. SBOP-Lyso demonstrated high singlet oxygen yield, good biocompatibility, and effective inhibition of A549 cells migration. The unique lysosome-targeted properties of SBOP-Lyso make it a promising candidate for cancer cell PDT.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Review
Chemistry, Multidisciplinary
Muhammad Rizwan Younis, Gang He, Junle Qu, Jing Lin, Peng Huang, Xing-Hua Xia
Summary: Inorganic nanomaterials with intrinsic singlet oxygen generation capability are emerging as nano-photosensitizers for photodynamic therapy, exhibiting high quantum yield. Various materials such as metal-based, metal oxide-based, metal sulfide-based, carbon-based, phosphorus-based, and others have been utilized for material design to achieve phototherapeutic effects, with future research facing numerous challenges.
Article
Chemistry, Inorganic & Nuclear
Chaochao Fan, Yue Wang, Jie Zhao, Yanxia Zhao, Dong Yang, Boyang Li, Le Yu, Xiao-Juan Yang, Biao Wu
Summary: In this study, two photoactive ligands were designed and used to construct sulfate complexes. These complexes can undergo oxygenation reactions under light, storing singlet oxygen, and partially recover the original structures after heating.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Applied
Pinar Sen, Rodah Soy, Sithi Mgidlana, John Mack, Tebello Nyokong
Summary: The emergence of antimicrobial resistance has made the development of photodynamic therapy (PDT) related applications essential, since microorganisms cannot develop resistance to this method. This study focuses on the synthesis, characterization, and evaluation of the utility of palladium porphyrins and their chitosan inclusion complexes as photosensitizer dye in photodynamic antimicrobial therapy (PACT). The photophysical-chemical studies showed that the immobilization of the porphyrins into the chitosan influenced their properties. Furthermore, the PACT activity of cationic porphyrin and its chitosan immobilization form were found to be effective in decreasing the number of viable cells up to 100% in vitro.
Article
Chemistry, Applied
Bingjie Hou, Wenyuan Zhang, Cuili Li, Xueqin Sun, Xiaoxia Feng, Jiacheng Liu
Summary: This study reports the synthesis and evaluation of four cationic porphyrins as potential photodynamic therapeutic agents. The results show that ZnP2 exhibits high phototoxicity towards cancer cells and low toxicity towards normal cells, making it a promising candidate for photodynamic therapy.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Chemistry, Inorganic & Nuclear
E. Pang, Shaojing Zhao, Benhua Wang, Guangle Niu, Xiangzhi Song, Minhuan Lan
Summary: This article systematically summarizes various strategies to improve the generation efficiency of singlet oxygen (O-1(2)) in photosensitizers (PS) and discusses their advantages, disadvantages, and challenges.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Engineering, Environmental
Ziyong Li, Si Chen, Yurou Huang, Hui Zhou, Shuren Yang, Haining Zhang, Mingxing Wang, Hui Guo, Jun Yin
Summary: Researchers have developed a novel photosensitizer system that allows for reversible control over singlet oxygen generation. This photosensitizer exhibits excellent aggregation-induced emission properties and photoswitching behavior, making it suitable for precise photodynamic therapy.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Chemistry, Analytical
Yuehui Liang, Jing Wang, Hao Zhang, Pengchao Yin, Ting Li, Qingyun Li, Qunliang Li, Youyan Liu, Hai-Bo Liu
Summary: A magnetic nano-fluorescent probe with high sensitivity and selectivity for singlet oxygen was designed and synthesized in this study. It was used to screen natural photosensitizers from traditional Chinese medicine and derivatives were designed to improve their efficiency. The probe offers a new strategy for screening photosensitizers and the derivatives provide directions for modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Physical
Jun-Yong Shin, Seung-Hwan Kim, Sunhee Lee, Yong Sup Lee, Won-Sik Han, Kang-Kyun Wang
Summary: The study found that introducing electron-withdrawing fluorine atoms into the PC moiety can significantly enhance singlet oxygen generation and promote intersystem crossing. Cyclic voltammetry experiments revealed a linear relationship between quenching rate constants and oxidation potentials, indicating that the substituent effect is a key factor governing the efficiency of photosensitizers in generating singlet oxygen.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Chemistry, Multidisciplinary
Xianbao Li, Qi Li, Aoli Wu, Junbai Li
Summary: Symmetry of layered dipeptide crystals can be broken by utilizing CO2, which induces adjacent monomolecular layers to stack in the same direction. CO2 covers the interlayer interaction sites, forcing the dipeptides to adsorb asymmetrically. The dipeptide crystals exhibit enhanced piezoelectricity and the piezoelectric voltage generated from dipeptide-based generators is increased by more than 500% after symmetry breaking. This work provides a potential route to engineer structures and properties of layered materials, and offers insights into the control of non-covalent interactions.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Linna Hao, Anhe Wang, Junjie Fu, Sen Liang, Qingquan Han, Yafeng Jing, Jieling Li, Qi Li, Shuo Bai, Peter H. Seeberger, Jian Yin
Summary: This study explores the application of peptide self-assembled hydrogels in hard tissue regeneration. By using peptide self-assembled nanostructures to emulate natural biomineralization process, vaterite nanoparticles loaded with thermolysin act as templates for collagen fibrils self-assembly and mineralization. Meanwhile, vaterite nanoparticles provide strong mechanical support and mineral ion release, enhancing the mechanical property and biocompatibility of the hydrogel.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Chemistry, Physical
Aoli Wu, Yongxian Guo, Xianbao Li, Qi Li, Guixin Chen, Hengchang Zang, Junbai Li
Summary: The development of peptide-based supramolecular materials with hierarchical morphology and tunable guest loading shows great potential as a drug carrier due to their biocompatibility and biodegradability. In this study, a facile Schiff base nanoarchitectonic was reported for the supramolecular assembly of diphenylalanine (FF) metastable gel. The competitive assembly between FF-H2O and FF-GA oligomer resulted in the formation of FF nanoparticles and hierarchical beaded nanofibers. These assembled particles can easily load various guest molecules and release them under weak alkaline conditions, demonstrating their potential application as drug carriers.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Multidisciplinary Sciences
Yamei Liu, Ruirui Xing, Junbai Li, Xuehai Yan
Summary: Covalently triggered peptide self-assembly has been developed for cancer theranostics, providing enhanced stability and functionality compared to noncovalent interactions. The review summarizes the design principles for constructing various peptide-based assemblies and discusses representative covalently assembled peptide-based nanodrugs, along with their challenges and potential in clinical applications for cancer diagnosis and therapeutics. This review offers new insights into the construction of peptide-based nanodrugs through covalent reaction and noncovalent self-assembly.
Article
Chemistry, Physical
Nan Sun, Yi Jia, Shiwei Bai, Qi Li, Luru Dai, Junbai Li
Summary: Super-resolution microscopy (SRM) technology has revolutionized the field of cell biology by breaking the diffraction limit, enabling researchers to visualize cellular structures with nanometric resolution, multiple colors, and single-molecule sensitivity. SRM has also extended its impact to other fields such as nanomedicine, material science, and nanotechnology, greatly contributing to breakthroughs in these areas.
ADVANCES IN COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Xin Li, Honglei Jian, Qingquan Han, Anhe Wang, Jieling Li, Ningyuan Man, Qi Li, Shuo Bai, Junbai Li
Summary: Short peptide self-assembled hydrogels have excellent biocompatibility and functional expansion, making them promising in cell culture and tissue engineering. However, the preparation of bio-inks with adjustable mechanical strength and controlled degradation for 3D bioprinting is challenging.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Zhenzhen Dong, Jinbo Fei, Tonghui Wang, Junbai Li
Summary: A strategy of matched spectral and temporal light management is developed to improve photosynthetic efficiency by co-assembling natural thylakoid membrane (TM) with artificial long afterglow particle (LAP). LAP with excellent stability and biocompatibility is optically-matched with the absorption of TM, serving as an additional light source for photosynthesis. Enhanced photosynthesis is achieved after co-assembly, with boosted electron transfer, oxygen yield, and ATP production due to down-conversion fluorescence emission from LAP. This proof-of-concept work opens a new route to augment the photosynthetic efficiency of green plants by utilizing precise light-managed materials.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Physical
Yilin Liu, Junbai Li
Summary: This study reports, for the first time, that Celastrol can self-assemble into size-controllable nanoparticles via the anti-solvent method using different solvents or varying Celastrol concentrations. In vitro experiments showed that the prepared nanoparticles can effectively kill MCF-7 cells. Furthermore, the nanoparticles can accumulate efficiently in tumors after intravenous injection. Administration of a lethal dosage of Celastrol resulted in significant tumor suppression with maintained activity in mice. These findings suggest that the anti-solvent method holds promise for fabricating Celastrol nano-drugs with controlled size and reduced systemic toxicity for clinical cancer treatment.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Zibo Li, Fanchen Yu, Xia Xu, Tonghui Wang, Jinbo Fei, Jingcheng Hao, Junbai Li
Summary: We demonstrate the realization of photozyme-catalyzed oxidative phosphorylation through the assembly of ATP synthase-reconstituted proteoliposome coatings on microcapsules. This is achieved through layer-by-layer deposition of semiconducting graphitic carbon nitride (g-C3N4) nanosheets and polyelectrolytes. The encapsulated g-C3N4 nanosheets act as the photozyme, accelerating the oxidation of glucose to yield protons under light illumination, establishing an outward transmembrane proton gradient to drive ATP synthesis. This artificial design enables higher energy conversion efficiency compared to conventional oxidative phosphorylation systems.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Peng Zhou, Ruirui Xing, Qi Li, Junbai Li, Chengqian Yuan, Xuehai Yan
Summary: Controlling the morphology of supramolecular hydrogels is crucial in tuning their mechanical properties. This study investigates the evolution of fibrillar networks in hydrogels by modulating droplets formed via liquid-liquid phase separation. The size and amount of droplets, as well as the structural evolution and network development, can be finely tuned by varying the thermal history. The findings provide insights into the role of phase-separated droplets in self-assembling networks and contribute to the engineering of supramolecular hydrogels with adjustable mechanical properties.
Review
Chemistry, Multidisciplinary
Rui Chang, Luyang Zhao, Ruirui Xing, Junbai Li, Xuehai Yan
Summary: This review summarizes recent advances in chromopeptide nanoarchitectonics, focusing on the design strategy, assembly mechanism, and structure-function relationship. The effect of peptide sequences and the variation in photophysical performance are critically emphasized. Various applications, including biomedicine and artificial photosynthesis, are discussed, along with the future prospects of chromopeptide nanoarchitectonics.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Chemistry, Multidisciplinary
Aoli Wu, Yongxian Guo, Meiqi Li, Qin Li, Hengchang Zang, Junbai Li
Summary: The assembly pathway and chiral transformation behavior of peptides in supramolecular peptide assemblies remain largely unknown. In this study, the assembly of an N-terminal-protected phenylalanine-tyrosine dipeptide is shown to proceed through multistep structural evolution, and the chiral assembly can be controlled by introducing a bipyridine derivative and using ultrasound or enzyme catalysis.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Physical
Nan Sun, Yi Jia, Shiwei Bai, Yang Yang, Luru Dai, Junbai Li
Summary: This study demonstrates the direct observation and quantification of protein corona adsorbed onto PEGylated mesoporous silica particles using direct stochastic optical reconstruction microscopy. The effects of PEG molecular weights and incubation time on protein penetration depth are investigated for the first time.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2024)
