Article
Materials Science, Biomaterials
Yang Bai, Xihua Li, Muqiong Li, Qingqing Shang, Jing Yang, Li Fan, Wei Tian
Summary: The construction of supramolecular prodrug self-assemblies that can effectively consume cellular glutathione (GSH) and inhibit its biosynthesis pathway is a general concern. This study utilized host-guest interactions to construct such self-assemblies, which showed excellent anti-tumor efficacy by depleting GSH and amplifying cellular oxidative stress.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Pharmacology & Pharmacy
Gabriela Pastuch-Gawolek, Julia Szreder, Monika Dominska, Mateusz Pielok, Piotr Cichy, Miroslawa Grymel
Summary: The number of cancer-related diseases is still increasing and the development of an ideal anticancer drug is still ongoing. Researchers are exploring targeted therapies and the use of prodrugs or encapsulation to deliver drugs precisely to cancer cells. Sugars are considered ideal ligands for targeted therapies and can also modify drug carriers. Numerous papers have been dedicated to the use of sugars for modifying or targeting anticancer compounds.
Article
Pharmacology & Pharmacy
Surabhi Kumari, Anuj Nehra, Kshitij Gupta, Anu Puri, Vinay Kumar, Krishna Pal Singh, Mukesh Kumar, Ashutosh Sharma
Summary: The authors developed biocompatible nano-vesicles using graphene oxide (GO) for the targeted release of chlorambucil (CHL) drugs in cancer cells. GO sheets were functionalized with folic acid (FA) molecules to improve controlled release and loading efficiency of CHL. The drug was loaded onto the GO surface through pi-pi stacking and hydrophobic interactions. In vitro release studies showed a pH-dependent release, with faster release at lower pH.
Article
Chemistry, Medicinal
Matan Soll, Vinay K. Sharma, Sally Khoury, Yehuda G. Assaraf, Zeev Gross
Summary: The nanoparticle-based system of 3-Ga NPs demonstrates remarkable tumor growth inhibition against human metastatic castration-resistant prostate cancer and shows potential as a sonodynamic agent for the treatment of pancreatic cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Yasar Akdogan, Sumeyra Cigdem Sozer, Cansu Akyol, Merve Basol, Cigdem Karakoyun, Gulcin Cakan-Akdogan
Summary: This study synthesized serum albumin nanoparticles in an ionic liquid system and successfully loaded and sustained released a hydrophobic anticancer drug. The drug-loaded nanoparticles showed significant cell death in Chl-sensitive cancer cells and reduced the toxicity compared to free Chl. The nanoparticles were also found to be non-toxic and eliminated by the zebrafish body. Overall, this research demonstrates the potential of serum albumin nanoparticles for drug delivery applications.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Polymer Science
Luigia Serpico, Stefania Dello Iacono, Luca De Stefano, Selene De Martino, Mario Battisti, Principia Dardano, Silvana Pedatella, Mauro De Nisco
Summary: In this study, two novel selenium glycoconjugates were developed as antioxidants for skin repair acceleration. These conjugates are capable of pH-sensitive release, making them a promising candidate for wound care practices.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Chemistry, Multidisciplinary
Pei Huang, Changrong Wang, Hongzhang Deng, Yongfeng Zhou, Xiaoyuan Chen
Summary: The development of multifunctional nanoparticles with desired properties is important in the field of nanotechnology and is expected to revolutionize cancer diagnosis and treatment. Surface engineering of nanoparticles is crucial for their in vivo fate, bioavailability, and theranostic outcomes. Different surface functionalities have been utilized to enhance cancer therapy and imaging, including inorganic and organic materials, biomembranes, and targeting moieties. These surface modifications have the potential to be applied in various scenarios and contribute to the clinical translation of NP-based platforms for cancer theranostics.
ACCOUNTS OF CHEMICAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Maria John Newton Amaldoss, Jia-Lin Yang, Pramod Koshy, Ashwin Unnikrishnan, Charles C. Sorrell
Summary: Inorganic nanoparticles used for drug delivery in cancer treatment offer numerous advantages, such as maximizing therapeutic effect through targeting ligands and minimizing side-effects. They have shown promising combined therapeutic capabilities, including anticancer effects and inhibition of cancer cell signaling pathways. Inorganic nanoparticles serve as synergistic platforms for RNA interference and as drug delivery agents for targeting cancer cell signaling pathways.
DRUG DISCOVERY TODAY
(2022)
Review
Chemistry, Multidisciplinary
Yu Han, Panyue Wen, Junjie Li, Kazunori Kataoka
Summary: Cisplatin is a successful chemotherapy drug, but its resistance and toxicity limit its clinical application. Targeted nanomedicine offers hope for maximizing efficacy and minimizing toxicity. This article reviews the recent progress and challenges in managing cisplatin resistance and toxicity and highlights future directions for development.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Engineering, Biomedical
Rui Sang, Bradley Stratton, Alexander Engel, Wei Deng
Summary: Conventional treatments for colorectal cancer severely impact advanced patients' therapeutic effects. The development of nanomedicines has led to liposomal delivery systems being considered promising for CRC treatment. Recent reviews have focused on preclinical research and drug delivery, but our review provides the latest advances in liposome technology for CRC with strong potential for clinical translation.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Gagandeep Singh, Gaya S. Dasanayake, Claylee M. Chism, Priyavrat Vashisth, Amandeep Kaur, Sandeep Kumar Misra, Joshua S. Sharp, Eden E. L. Tanner
Summary: Achieving safe and efficacious drug delivery remains a challenge, and this study presents a promising approach using biocompatible GBILs to modify the surface of PLGA nanoparticles. The modified nanoparticles showed enhanced uptake by breast cancer cells and could potentially serve as a versatile platform for targeted drug delivery and gene therapy applications.
MATERIALS CHEMISTRY FRONTIERS
(2023)
Article
Pharmacology & Pharmacy
Supriti Ghosh, Pradyumna Jayaram, Shama Prasada Kabekkodu, Kapaettu Satyamoorthy
Summary: Cervical cancer is a prevalent cancer among women worldwide, but it can be preventable. Nanotechnology has provided a solution for targeted drug delivery due to the limitations of conventional chemotherapeutics. This review summarizes various drug delivery approaches and nanocarriers, their advantages, limitations, and potential applications.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Sijongesonke Peter, Blessing Atim Aderibigbe
Summary: Increasing cases of cancer have raised concerns in recent decades. Developing new chemotherapeutics faces challenges such as drug resistance and toxicity. Hybrid compounds combining Chlorambucil with other pharmacophores show potential as effective anticancer agents with fewer side effects.
Article
Chemistry, Multidisciplinary
Zhiduo Sun, Weiyun Zhang, Zhichao Ye, Li Yuan, Manli Fu, Xiaoming Liu, Huageng Liang, Heyou Han
Summary: This study presents the design of a novel nanocarrier DNAH for the treatment of bladder cancer, utilizing photothermal therapy to overcome the bladder mucosal barrier and enhance drug penetration. The results demonstrate the potential inhibition of bladder tumor growth by DNAH, leading to improved survival time in mice.
Review
Chemistry, Inorganic & Nuclear
Hardev Singh, Divya Sareen, Jiya Mary George, Vineet Bhardwaj, Saehee Rha, Suk Joong Lee, Sheetal Sharma, Amit Sharma, Jong Seung Kim
Summary: Mitochondria, as the most critical target in cell physiology, have attracted substantial attention in cancer therapy due to their structural and functional discrepancies between normal and cancerous cells. Various synthetic strategies are used to deliver cytotoxins exclusively to mitochondria, achieving significant mitochondrial accumulations by proper selection of cell types and targeting unit. This review article addresses different strategies for targeting cancerous mitochondria with small molecule-based theranostics for diagnostic and potential therapeutic purposes since 2015.
COORDINATION CHEMISTRY REVIEWS
(2022)