Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 22, Issue 34, Pages 11918-11933Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201600885
Keywords
arenes; asymmetric catalysis; dearomatization; halogenation; synthetic methods
Categories
Funding
- National Basic Research Program of China (973 Program) [2015CB856600]
- National Natural Science Foundation of China [21302209, 21332009, 21361140373, 21421091]
- Program of Shanghai Subject Chief Scientist [16XD1404300]
- Chinese Academy of Sciences
Ask authors/readers for more resources
Recent advances in dearomatization through halofunctionalization reactions are summarized in this Minire-view. Two general categories of strategies are currently employed in this field. On one hand, the reaction can be initiated with electrophilic halogenation at an alkyne or alkene moiety. The resulting halonium ion intermediate is then captured by a pendant aromatic ring at the ipso position, affording the dearomatization product. On the other hand, electrophilic halogenation can directly take place at a substituted arene, and the final dearomatization product is furnished by deprotonation or intramolecular nucleophilic trap. Highly enantioselective variants have been realized in the latter case by organocatalysis or transition metal catalysis. By applying these methods, various valuable halogenated polycyclic molecular architectures have been obtained from readily available starting materials.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available