Article
Ophthalmology
Yifang Yang, Junshu Wu, Defu Wu, Qi Wei, Tan Zhong, Jun Yang, Xiaowei Yang, Meizhen Zeng, Xingwu Zhong
Summary: Among the 3 different administration methods, intravitreal injection of brimonidine was the most effective in slowing myopia progression in the FD guinea pig model. Intravitreal brimonidine at 4 mu g/mu L significantly reduced the development of FD myopia in guinea pigs. Expression levels of the Col1a1 and Mmp2 genes were significantly increased in the retinal tissues of the FD-Inj-Br group.
Article
Oncology
Lu Tian, Ya-Tu Guo, Ming Ying, Yang-Chen Liu, Xuan Li, Yan Wang
Summary: In this study, it was found that long periods of monocular form deprivation in guinea pigs resulted in significant refractive errors and increased axial lengths in the deprived eyes. Myopia was established at 4 weeks, while amblyopia may have occurred as early as 1 week of deprivation. This suggests that amblyopia likely precedes myopia and both conditions coexist after prolonged form deprivation in guinea pigs.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yajun Wu, Yuliang Feng, Jiasong Yang, Hua Fan, Zitong Yu, Xiaolin Xie, Yumeng Dai, Xin Huang, Wensheng Li
Summary: The aim of this study was to investigate the effects of exogenous retinoic acid (RA) on intraocular parameters, especially choroidal thickness (CT) and retinal thickness (RT), in guinea pigs with form deprivation myopia (FDM). After 4 weeks, it was found that RA can increase the refractive error, axial length, and intraocular pressure of FDM guinea pigs, and might aggravate the retinal thinning. Citral, on the other hand, can inhibit these changes, but may not affect the thickness of the choroid.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Ophthalmology
Lei Guo, Rui Hua, Xinxin Zhang, Ting Yu Yan, Yang Tong, Xin Zhao, Shi Chao Chen, Moying Wang, Neil M. Bressler, Jun Kong
Summary: The study finds that scleral cross-linking may cause glaucomatous changes in guinea pig eyes and raises safety concerns for controlling myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Hong Liu, Donglong Chen, Zhikuan Yang, Xiaoning Li
Summary: The study aimed to investigate the morphological and functional changes caused by atropine during myopia inhibition. It was found that there were significant differences between the atropine group and the saline group in terms of refraction error, axial length, and retinal and choroidal thickness. Atropine may mainly affect the outer retina in guinea pigs during the process of inhibiting form-deprived myopia.
CURRENT EYE RESEARCH
(2022)
Article
Neurosciences
Ming-Ming Duan, Hui Liu, Yu-Lin Zhong
Summary: The purpose of this study was to investigate changes in retina thickness in myopic mice using optical coherence tomography (OCT). The results showed that the refractive power of the right eye in the form-deprivation myopia (FDM) group was significantly higher than that of the left eye after 4 weeks of form deprivation. The retina, nerve fiber layer (NFL), inner nuclear layer (INL), and outer nuclear layer (ONL) in the right eye of the FDM group were significantly thinner.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Ophthalmology
Liqin Jiang, Xinyu Liu, Lei Zhou, Joanna M. Fianza Busoy, Myo Thu Khine, Yee Shan Dan, Mengyuan Ke, Noel A. Brennan, Karen J. Catbagan, Leopold Schmetterer, Veluchamy A. Barathi, Quan Hoang
Summary: This study aimed to investigate the relationship between choroidal characteristics and susceptibility to myopia development. The results showed that greater choroidal thickness could protect against myopia, while lower choroidal thickness was associated with a higher susceptibility to myopia development. Dysfunction of the choroidal vascular system may be the underlying mechanism.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Man She, Bing Li, Tao Li, Xiaodong Zhou
Summary: The expression levels of AREG in the sclera of guinea pigs increased during the development of FDM and downregulated after recovery of FDM. Therefore, AREG may play a role in regulating scleral remodeling in myopia.
CURRENT EYE RESEARCH
(2022)
Article
Biochemical Research Methods
Pinghui Wei, Guoge Han, Yan Wang
Summary: In this study, the changes in metabolism of the retinal pigment epithelial/choroid complex were investigated, and it was found that dopamine D2 receptor antagonists can modulate eye development and are associated with the dopamine D2 receptor signaling pathway. These findings are important for understanding the pathogenesis of myopia and developing potential therapeutic approaches.
Article
Ophthalmology
So Goto, Sandra E. Muroy, Yan Zhang, Kaoru Saijo, Sree Rohit Raj Kolora, Qiurong Zhu, Christine F. Wildsoet
Summary: This study identified key RPE genes linked to myopia induction in guinea pigs, with significant differences in gene expression, particularly for BMP2, confirming its important role in eye growth regulation. Enrichment for BMP and TGF-beta signaling pathways were also observed.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Shanshan Ge, Yuehua Zhou, Chen Li, Mingxu Zhang
Summary: The aim of this study was to investigate the normal retinal vascular oxygen saturation and factors associated with it in a Chinese population. The results showed that retinal arteriolar oxygen saturation (SaO(2)) increased with older age, lower myopia, and larger corneal curvature, while retinal venous oxygen saturation (SvO(2)) decreased with increasing myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Ophthalmology
Guimei Zhou, Changjun Lan, Qin Yang, Weiqi Zhong, Zhiming Gu, Xiaoling Xiang, Yumei Mao, Xuan Liao
Summary: The study found that after four weeks of form deprivation, the refractive degree and axial length of guinea pigs significantly increased, the retinal and scleral tissues became thinner, and the protein and mRNA expression levels of SCO1 and SCO2 were significantly reduced in the FDM group.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Amanda Miles, Vincent Tropepe
Summary: The vertebrate retina develops from specified precursor cells that generate lineages of neural retina, retinal pigmented epithelium, or ciliary body. In some species, proliferative stem-cell-like cells located at the peripheral margin, possibly representing a conserved retinal stem cell niche, continuously supply new retinal cells post-embryonically. This review highlights the research characterizing similar stem-like cells across different species and discusses their role in regulating retinal growth and plasticity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Pinghui Wei, Guoge Han, Meiqin He, Yan Wang
Summary: This study aimed to investigate the changes in retinal neurotransmitters and the role of the dopamine D2 receptor (D2R) pathway in regulating myopic refractive state. The results showed that after forced occlusion for 4 weeks, dopamine (DA) and γ-aminobutyric acid (GABA) concentrations decreased, while glutamate (Glu), 3-methoxytyramine (3-MT), and glycine concentrations increased, accompanied by an increase in myopic refraction and axial length (AL). Treating with D2R antagonist sulpiride increased glycine and DA levels, while decreasing 3-MT and Glu levels, accompanied by a decrease in myopic refraction and AL. The ratio of Glu to GABA (RGG) represents the balance between excitatory and inhibitory neurotransmitters, and changes in RGG correlated with changes in AL.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Ophthalmology
Qian Fu, Yue Zhang, Linji Chen, Mengmeng Dong, Wenyu Tang, Si Chen, Jia Qu, Xiangtian Zhou, Zhina Zhi
Summary: This study establishes a model for near work myopia induced by short viewing distance in guinea pigs and evaluates the effect of viewing distance on myopia development. The findings suggest that short viewing distance could be a risk factor for myopia and provide a useful model for studying the underlying mechanisms.
EXPERIMENTAL EYE RESEARCH
(2022)