Article
Endocrinology & Metabolism
Tsung-Cheng Hsieh, Guang-Hong Deng, Yung-Ching Chang, Fang-Ling Chang, Ming-Shan He
Summary: This study aimed to investigate optical coherence tomography (OCT) biomarkers of diabetic macular edema (DME) refractory to anti-vascular endothelial growth factor (anti-VEGF) therapy. The results showed that partially continuous inner segment-outer segment (IS-OS) layers were predictive of better response, while epiretinal membrane (ERM) was a significant predictor of poor response.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yunyan Hu, Yunkao Zeng, Jing Yang, Xiaomin Zeng, Dan Cao, Biqun Ou, Guanrong Zhang, Liang Zhang
Summary: This study investigated the changes in intraocular pressure after intravitreal injection of Conbercept and evaluated the associated risk factors. The results showed that intravitreal injection of Conbercept may cause a rapid spike in intraocular pressure, but is safe in the short term. Older age and shorter axial length are associated with higher intraocular pressure after injection.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Ophthalmology
Ana Navarrete, Brice Vofo, Katherine Matos, Antonio Rivera, Itay Chowers, Jaime Levy
Summary: The study aimed to determine the anatomical consequences of delaying intravitreal injection therapy with anti-vascular endothelial growth factor. The results showed a significant correlation between treatment delay and increased macular thickness, which may impact visual outcomes.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Review
Pharmacology & Pharmacy
Chengming Chen, Zhaoyang Wang, Weiming Yan, Yanyan Lan, Xiaolong Yan, Tian Li, Jing Han
Summary: In the treatment of diabetic macular edema, the combination of anti-VEGF and ocular corticosteroids has a significant advantage within the first 3 months. However, as the treatment cycle prolongs, the effect of combination therapy is no better than monotherapy, and the side effects are more severe.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Chemistry, Medicinal
Dan Lin, Jiajiang Hu, Ke Wu, Kemi Feng, Xia Zhao, Qingqing Lu, Mingxue Ren, Junlin Cao, Ruru Liu, Mali Dai, Kaihui Nan, Yuqin Wang
Summary: The combination therapy of intravitreal anti-VEGF and sub-Tenon triamcinolone acetonide injection is more effective than triamcinolone acetonide injection alone in reducing uveitic macular edema and restoring visual acuity. The addition of anti-VEGF does not increase the risk of steroid-induced elevation of intraocular pressure over a period of 6 months.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Review
Pharmacology & Pharmacy
Weijie Zou, Yuanyuan Du, Xiaoyan Ji, Ji Zhang, Hongping Ding, Jingqiao Chen, Tao Wang, Fangfang Ji, Jiang Huang
Summary: This study compared the effectiveness of anti-VEGF drugs intravitreal injections (IVI) with or without retinal laser photocoagulation (LPC) for macular edema (ME) secondary to retinal vein occlusion (RVO). The results showed that there was no significant difference in improving visual acuity and reducing macular thickness between the combination treatment and single IVI treatment. However, the combination treatment significantly reduced the number of intravitreal injections in patients with BRVO.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Akira Watanabe, Hirotugu Takashina, Tadashi Nakano
Summary: This study investigated the effects of anti-vascular endothelial growth factor (VEGF) treatment on diabetic macular edema (DME) and found that the number and leaking status of microaneurysms (MAs) have an impact on the therapeutic efficacy. The results showed a correlation between the number of MAs and retinal thickness, both before and after treatment. There was also a significant difference in thickness between leaking and non-leaking MAs. The degree of retinal edema before treatment is associated with the number and presence of leaking MAs.
Article
Ophthalmology
Rajya L. Gurung, Liesel M. FitzGerald, Ebony Liu, Bennet J. McComish, Georgia Kaidonis, Bronwyn Ridge, Alex W. Hewitt, Brendan Jt Vote, Nitin Verma, Jamie E. Craig, Kathryn P. Burdon
Summary: The study found that insulin therapy does not affect the effectiveness of anti-VEGF injection treatment for diabetic macular edema.
Article
Medicine, General & Internal
Youling Liang, Bin Yan, Manyun Xie, Zhishang Meng, Jiayue Ma, Bosheng Ma, Jing Luo
Summary: Comparing the effect of intravitreal ranibizumab and dexamethasone implant on diabetic macular edema (DME) in vitrectomized eyes, the study found that dexamethasone implant was more effective in improving visual acuity and reducing central retinal thickness (CRT) at 1 month.
FRONTIERS IN MEDICINE
(2022)
Article
Medicine, Research & Experimental
Haoxin Guo, Wenbo Li, Zetong Nie, Xiang Zhang, Mingfei Jiao, Siqiong Bai, Naxin Duan, Xiaorong Li, Bojie Hu
Summary: The study aims to investigate whether early pars plana vitrectomy combined with internal limiting membrane peeling can be an initial treatment option for treatment-naive diabetic macular edema (DME) patients.
Article
Ophthalmology
Hakan Koc, Atilla Alpay, Suat Hayri Ugurbas
Summary: This study compared the efficacy of monthly anti-VEGF therapy with dexamethasone implant in patients with diabetic macular edema (DME) whose macular edema persists despite three doses of anti-VEGF therapy. The results showed no significant difference in central macular thickness (CMT), best-corrected visual acuity (BCVA), and intraocular pressure (IOP) between the two treatment groups at six months. Therefore, switching to a dexamethasone implant may have similar efficacy as continuing with anti-VEGF therapy in this patient population.
Article
Health Care Sciences & Services
Yousif Subhi, Ivan Potapenko, Javad Nouri Hajari, Morten la Cour
Summary: This study analyzed the incidence rates of diabetic macular edema (DME) patients receiving anti-VEGF therapy and developed a model to forecast the future number of patients in active treatment. The results showed higher incidence rates among male and 60-80 years old patients. The number of patients in active treatment followed an exponential decay curve and is expected to remain relatively stable until 2023 with a minimal increase.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Patricia Mirete, Carmen Munoz-Morata, Cesar Albarran-Diego, Enrique Espana-Gregori
Summary: This study aimed to analyze the variation in subfoveal choroidal thickness (SFCT) and its relationship with the variation in central macular thickness (CME) in response to intravitreal therapy with an antiangiogenic (anti-VEGF) drug or corticosteroid in type 2 diabetic patients with diabetic macular edema (DME). The results showed that SFCT significantly decreased in response to intravitreal therapy with anti-VEGF or corticosteroids, and the reduction in CME was greater when using corticosteroid treatment. SFCT can be used to monitor the response to treatment but is not a good predictor of CME response.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Sashwanthi Mohan, Gajendra Chawla, Janani Surya, Rajiv Raman
Summary: This study aimed to compare visual and OCT outcomes in patients with CI-DME who received intravitreal anti-VEGF therapy with and without topical NSAIDs. The results showed no significant differences in visual acuity and OCT thickness between the two groups after 1 year of follow-up.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Saif Aldeen Alryalat, Mohammad Al-Antary, Yasmine Arafa, Babak Azad, Cornelia Boldyreff, Tasneem Ghnaimat, Nada Al-Antary, Safa Alfegi, Mutasem Elfalah, Mohammed Abu-Ameerh
Summary: This research aimed to develop a DL model for predicting response to anti-VEGF injections among DME patients. The segmentation DL model showed high accuracy in image segmentation, while the classification DL model achieved a 75% accuracy in classifying patients' response to treatment, comparable to ophthalmologists' accuracy.
Article
Ophthalmology
M. Awe, S. Khalili-Amiri, I. R. Volkmann, B. Junker, C. Framme, K. Hufendiek
Article
Cardiac & Cardiovascular Systems
Regalla Kumarswamy, Christophe Bauters, Ingo Volkmann, Fleur Maury, Jasmin Fetisch, Angelika Holzmann, Gilles Lemesle, Pascal de Groote, Florence Pinet, Thomas Thum
CIRCULATION RESEARCH
(2014)
Article
Cardiac & Cardiovascular Systems
Milosz Jaguszewski, Julia Osipova, Jelena-Rima Ghadri, Lars Christian Napp, Christian Widera, Jennifer Franke, Marcin Fijalkowski, Radoslaw Nowak, Marta Fijalkowska, Ingo Volkmann, Hugo A. Katus, Kai C. Wollert, Johann Bauersachs, Paul Erne, Thomas F. Luescher, Thomas Thum, Christian Templin
EUROPEAN HEART JOURNAL
(2014)
Article
Cardiac & Cardiovascular Systems
Regalla Kumarswamy, Ingo Volkmann, Julia Beermann, Lars Christian Napp, Olga Jabs, Raj Bhayadia, Anette Melk, Ahmet Ucar, Kamal Chowdhury, Johan M. Lorenzen, Shashi Kumar Gupta, Sandor Batkai, Thomas Thum
EUROPEAN HEART JOURNAL
(2014)
Article
Endocrinology & Metabolism
Julia Osipova, Dagmar-Christiane Fischer, Seema Dangwal, Ingo Volkmann, Christian Widera, Katrin Schwarz, Johan M. Lorenzen, Corinna Schreiver, Ulrike Jacoby, Mirjam Heimhalt, Thomas Thum, Dieter Haffner
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2014)
Article
Ophthalmology
Katharina Knoll, Kristine Chobanyan-Juergens, Dirk O. Stichtenoth, Ingo Roland Volkmann, Katerina Hufendiek, Carsten Framme
Article
Ophthalmology
Carsten Framme, Hans Hoerauf, Joachim Wachtlin, Ingo Volkmann, Martin Bartram, Bernd Junker, Nicolas Feltgen
Article
Ophthalmology
Maximilian Buettner, Benjamin Luger, Wasim Abou Moulig, Bernd Junker, Carsten Framme, Christina Jacobsen, Katharina Knoll, Amelie Pielen
Summary: The study found that single or repetitive SRT treatment may be effective and safe in two thirds of patients suffering from acute persistent CSC after 6 months of symptoms or more. Treatment success, defined as complete resolution of SRF, occurred in around 60% of eyes 12 weeks after the first SRT treatment and also 12 weeks after Re-SRT treatment.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Carsten Framme, Oliver Greb, Sascha Bayer, Pascal Buley, Amelie Pielen, Katerina Hufendiek, Bernd Junker, Ingo Volkmann
Summary: The treatment of macular edema with intravitreal injections is a chronic treatment that requires patient adherence and proper patient flow management. By optimizing processes, resources can be better utilized to meet increased demands, resulting in greater patient adherence and better visual outcomes.
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE
(2021)
Article
Ophthalmology
C. Framme, M. Dittberner, K. Rohwer-Mensching, J. Gottschling, P. Buley, K. Hufendiek, B. Junker, J. Tode, F. Lammert, I Volkmann
Summary: The study evaluated the turnover, costs, and workload of the University Eye Outpatient Department of the Hannover Medical School. The results showed that regular outpatient revenues were insufficient and were mainly balanced by outpatient surgery, self-pay patients, and other revenues.
Article
Ophthalmology
Carsten Framme, Bernd Junker, Nicolas Feltgen, Hans Hoerauf, Nina-Antonia Striebe, Joachim Wachtlin, Ingo Volkmann
Summary: Intravitreal injection is a common surgical procedure for treating macular diseases, but there are potential misinterpretations in the indications and duration of treatment, leading to the improper use of drugs, highlighting the importance of differential diagnosis.
Article
Ophthalmology
C. Jacobsen, I Volkmann, F. Wedegartner, J. Harris, B. Bertram, B. Bambas, C. Framme
Summary: Experiences of aggression and violence have a significant impact on job satisfaction and can have long-term psychological and physical effects on employees. A survey conducted by the Professional Association of Ophthalmologists and the German Ophthalmological Society revealed that a considerable number of ophthalmologists have experienced aggression and violence, particularly in the form of verbal abuse and threats. These incidents are often caused by intercultural conflicts, long waiting times, appointment allocation issues, high expectations, differences in treatment, and general aggressiveness.
Article
Ophthalmology
C. Framme, T. Kuiper, W. Lobbes, J. Gottschling, D. Scheinichen, K. Hufendiek, T. Palmaers, J. Tode, I Volkmann, F. Lammert
Summary: This study evaluated the efficiency of the surgical performance at a university eye hospital and found that reducing transfer time can increase operation time and improve the number of surgeries performed. Increasing personnel expenditure is economically worthwhile for surgical departments such as ophthalmology.
Article
Ophthalmology
Ameli Gabel-Pfisterer, Daniel Boehringer, Hansjuergen Agostini
Summary: This study compares the number, patterns, and histories of eye injuries caused by fireworks in Germany during two years of sales ban and previous years. The results show a decrease in the absolute number of eye injuries during the pandemic, an increase in the proportion of severe injuries, and a slight increase in the use of homemade or unofficially purchased fireworks.