BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

Mitochondria in human pluripotent stem cell apoptosis

(2016) Tara TeSlaa et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia

(2016) Adrian Kee Keong Teo et al.   Stem Cell Reports

Fas-Activated Mitochondrial Apoptosis Culls Stalled Embryonic Stem Cells to Promote Differentiation

(2015) Eric S. Wang et al.   CURRENT BIOLOGY

PDX1 Binds and Represses Hepatic Genes to Ensure Robust Pancreatic Commitment in Differentiating Human Embryonic Stem Cells

(2015) Adrian Kee Keong Teo et al.   Stem Cell Reports

Generation of Functional Human Pancreatic β Cells In Vitro

(2014) Felicia W. Pagliuca et al.   CELL

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

New Opportunities: Harnessing Induced Pluripotency for Discovery in Diabetes and Metabolism

(2013) Adrian Kee Keong Teo et al.   Cell Metabolism

Structure-guided design of a selective BCL-XL inhibitor

(2013) Guillaume Lessene et al.   Nature Chemical Biology

Sfrp5 Modulates Both Wnt and BMP Signaling and Regulates Gastrointestinal Organogensis in the Zebrafish, Danio rerio

(2013) Carsten Stuckenholz et al.   PLoS One

Human Embryonic Stem Cells Have Constitutively Active Bax at the Golgi and Are Primed to Undergo Rapid Apoptosis

(2012) Raluca Dumitru et al.   MOLECULAR CELL

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Bcl-xLregulates mitochondrial energetics by stabilizing the inner membrane potential

(2011) Ying-bei Chen et al.   JOURNAL OF CELL BIOLOGY

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase

(2011) Kambiz N. Alavian et al.   NATURE CELL BIOLOGY

Overexpression of BCL2 enhances survival of human embryonic stem cells during stress and obviates the requirement for serum factors

(2011) R. Ardehali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Islet  -Cells Deficient in Bcl-xL Develop but Are Abnormally Sensitive to Apoptotic Stimuli

(2009) E. M. Carrington et al.   DIABETES

Prosurvival Bcl-2 proteins stabilize pancreatic mitochondria and protect against necrosis in experimental pancreatitis

(2009) Kai-Feng Sung et al.   EXPERIMENTAL CELL RESEARCH

Sfrp5 coordinates foregut specification and morphogenesis by antagonizing both canonical and noncanonical Wnt11 signaling

(2008) Y. Li et al.   GENES & DEVELOPMENT