In Vivo Targeting of Clostridioides difficile Using Phage-Delivered CRISPR-Cas3 Antimicrobials

Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind, placebo-controlled, non-inferiority, randomised phase 3 trials

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Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA)

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Changes in Prevalence of Health Care–Associated Infections in U.S. Hospitals

(2018) Shelley S. Magill et al.   NEW ENGLAND JOURNAL OF MEDICINE

Engineering Bacteriophages as Versatile Biologics

(2018) Samuel Kilcher et al.   TRENDS IN MICROBIOLOGY

Extending the Host Range of Bacteriophage Particles for DNA Transduction

(2017) Ido Yosef et al.   MOLECULAR CELL

Effect of a genetically engineered bacteriophage on Enterococcus faecalis biofilms

(2016) Justine Monnerat Tinoco et al.   ARCHIVES OF ORAL BIOLOGY

CRISPR Diversity and Microevolution inClostridium difficile

(2016) Joakim M. Andersen et al.   Genome Biology and Evolution

Prophages mediate defense against phage infection through diverse mechanisms

(2016) Joseph Bondy-Denomy et al.   ISME Journal

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

(2016) Jenessa A. Winston et al.   Jove-Journal of Visualized Experiments

Bacteriophage Combinations Significantly Reduce Clostridium difficile GrowthIn Vitroand ProliferationIn Vivo

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Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease

(2015) Anna M. Seekatz et al.   INFECTION AND IMMUNITY

TheClostridium difficilecell wall protein CwpV confers phase-variable phage resistance

(2015) Ognjen Sekulovic et al.   MOLECULAR MICROBIOLOGY

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Burden of Clostridium difficile Infection in the United States

(2015) Fernanda C. Lessa et al.   NEW ENGLAND JOURNAL OF MEDICINE

CRISPR-based screening of genomic island excision events in bacteria

(2015) Kurt Selle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile

(2015) Pierre Boudry et al.   mBio

Engineering Modular Viral Scaffolds for Targeted Bacterial Population Editing

(2015) Hiroki Ando et al.   Cell Systems

Characterization of Temperate Phages Infecting Clostridium difficile Isolates of Human and Animal Origins

(2014) Ognjen Sekulovic et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Sequence-specific antimicrobials using efficiently delivered RNA-guided nucleases

(2014) Robert J Citorik et al.   NATURE BIOTECHNOLOGY

Exploiting CRISPR-Cas nucleases to produce sequence-specific antimicrobials

(2014) David Bikard et al.   NATURE BIOTECHNOLOGY

Programmable Removal of Bacterial Strains by Use of Genome-Targeting CRISPR-Cas Systems

(2014) A. A. Gomaa et al.   mBio

The relationship between phenotype, ribotype, and clinical disease in human Clostridium difficile isolates

(2013) Paul E. Carlson et al.   ANAEROBE

In vitro reconstitution of Cascade-mediated CRISPR immunity in Streptococcus thermophilus

(2013) Tomas Sinkunas et al.   EMBO JOURNAL

Genetic modifications to temperate Enterococcus faecalis phage  Ef11 that abolish the establishment of lysogeny and sensitivity to repressor, and increase host range and productivity of lytic infection

(2013) H. Zhang et al.   MICROBIOLOGY-SGM

Evidence ofIn VivoProphage Induction during Clostridium difficile Infection

(2012) Mathieu Meessen-Pinard et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

In vivo lysogenization of a Clostridium difficile bacteriophage ФCD119

(2011) Govind Revathi et al.   ANAEROBE

Cas3 is a single-stranded DNA nuclease and ATP-dependent helicase in the CRISPR/Cas immune system

(2011) Tomas Sinkunas et al.   EMBO JOURNAL