Article
Pharmacology & Pharmacy
Ruidong Li, Wenchang Yang, Yuping Yin, Xianxiong Ma, Peng Zhang, Kaixiong Tao
Summary: The study demonstrated that 4-Octyl itaconate has protective effects on CCl4-induced acute liver injury by alleviating oxidative stress and the inflammatory response, possibly associated with the elevation of Nrf2 nuclear translocation and inhibition of HMGB1 mediated nuclear translocation of NF-kappa B.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jin H. Song, Joseph B. Mascarenhas, Saad Sammani, Carrie L. Kempf, Hua Cai, Sara M. Camp, Tadeo Bermudez, Donna D. Zhang, Viswanathan Natarajan, Joe G. N. Garcia
Summary: This study investigated the mechanisms underlying TLR4-mediated inflammatory responses leading to loss of endothelial cell barrier function and increased vascular permeability, with a focus on the essential role of the Dock1 and Elmo1 complexes in this process.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Chemistry, Medicinal
Ahmed Mohsen Elsaid Hamdan, Fatimah Hussain J. Alharthi, Ahmed Hadi Alanazi, Soad Z. El-Emam, Sameh S. Zaghlool, Kamel Metwally, Sana Abdulaziz Albalawi, Yahia S. Abdu, Reda El-Sayed Mansour, Hoda A. Salem, Zakaria Y. Abd Elmageed, Karema Abu-Elfotuh
Summary: The study demonstrates that phytochemicals combined with physical and mental activities have neuroprotective effects on an aluminum-induced Alzheimer's disease rat model, slowing down the progression of the disease by modulating multiple signaling pathways.
Article
Endocrinology & Metabolism
Hossam Kamli, Mehedi Hasan Bappi, Tawhida Islam, Rajib Hossain, M. D. Munnaf Hossen, Abdullah Al Faruq, Joao Arthur de Oliveira Borges, Isaac Moura Araujo, Ray Silva de Almeida, Henrique Douglas Melo Coutinho, Catarina Martins Tahim, Elaine Cristina Pereira Lucetti, Muhammad Torequl Islam
Summary: The ethanolic leaf extract of U. sinuata demonstrates antioxidant, anti-inflammatory, and anxiolytic activity, making it a potential source of plant-based active compounds for treating inflammation, oxidative stress, and neurological diseases.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Tian Hu, Yan Zhao, Yan Long, Xiaoqing Ma, Ya Zeng, Weijie Wu, Chongtian Deng, Mengling Li, Siyuan Peng, Hanzhi Yang, Mi Zhou, Jinyue Hu, Yueming Shen
Summary: This study found that TLR4 contributes to ER stress-induced inflammation in IBD and may be mediated by p38 MAPK signaling. TLR4 and p38 MAPK signaling are potential novel therapeutic targets for IBD.
BIOSCIENCE REPORTS
(2022)
Article
Environmental Sciences
Zhihua Qiao, Xinlin Sun, Kailin Gong, Xiuping Zhan, Kailun Luo, Mengru Fu, Shanqi Zhou, Yanna Han, Yuyou He, Cheng Peng, Wei Zhang
Summary: This study investigated the effects of DBDPE on hydroponic lettuce and explored its response mechanisms. The results showed that DBDPE induced oxidative stress and cell structure damage in lettuce, disrupted metabolic pathways, leading to decreased chlorophyll content and root activity. However, metabolic regulation alleviated antioxidant stress.
ENVIRONMENTAL POLLUTION
(2023)
Article
Environmental Sciences
Anouar Feriani, Meriam Tir, Waleed Aldahmash, Kais Mnafgui, Alimi Hichem, Ana Maria Gomez-Caravaca, Maria Del Mar Contreras, Amani Taamalli, Saleh Alwasel, Antonio Segura-Carretero, Nizar Tlili, Abdel Halim Harrath
Summary: The aim of this study was to investigate the cardiopreventive effect of the methanolic extract of S. molle L. (MESM) on isoproterenol-induced infarction in rats. The results showed that MESM exhibited cardioprotective effects by normalizing cardiac risk parameters, reducing oxidative stress, inhibiting apoptosis, reducing DNA fragmentation and infarct size, and inhibiting fibrosis in myocardial tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shuli Man, Lu Xie, Xuanshuo Liu, Genbei Wang, Changxiao Liu, Wenyuan Gao
Summary: Diosgenin extracted from fenugreek, yam, and other foods exhibits pharmacological activities that are effective in treating pain and nervous system diseases. This study investigated the mechanisms of diosgenin in chemotherapy-induced peripheral neuropathy (CIPN). The results showed that diosgenin protected PC12 cells from injury and reduced pain symptoms in CIPN mice. It inhibited oxidative stress, glial fibrillary acidic protein, and pro-inflammatory cytokines in the brain. Furthermore, it improved CIPN through modulation of the gut microbiota. In conclusion, diosgenin has the potential to ameliorate peripheral neuropathy and should be further studied for neuropathic pain treatment.
Review
Medicine, Research & Experimental
Jingyi Wu, Yaw-Syan Fu, Kaihuang Lin, Xin Huang, Yi-jing Chen, Dong Lai, Ning Kang, Liyue Huang, Ching-Feng Weng
Summary: This review article compiles published literature on the pharmacological properties of syringaldehyde (SA), a key compound in whisky and brandy. Using molecular docking and in vitro and in vivo assays, the study validates the medicinal properties of SA, including anti-oxidation, anti-inflammation, and anti-diabetes effects. The results show that SA has significant binding affinity with various proteins involved in inflammation and diabetes. The study suggests that in silico screening combined with preclinical tests could lead to new indications for drug discovery and development.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Agriculture, Multidisciplinary
Bowei Du, Chao Zhang, Guiya Deng, Shuai Zhang, Shiqi Wang, Yuepeng Guan, Yaqin Huang
Summary: This study identified novel antioxidant collagen peptides and investigated their mechanisms of action in blocking Keap1-Nrf2 interactions. The results showed that IDGRPGPIGPA exhibited high scavenging capacity for free radicals, while GPAGPpGPIG improved the resistance of cells to oxidative damage by activating intracellular antioxidant enzymes and glutathione production.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Environmental Sciences
Xiangfeng Yao, Jingwen Zhang, Can Wang, Qian Wang, Xianxu Li, Dexin Zhang, Jinhua Wang, Lusheng Zhu, Jun Wang
Summary: This study evaluated the toxic effects of dibutyl phthalate (DBP) on pakchoi (Brassica campestris L.), a typical vegetable crop. DBP exposure reduced the emergence of pakchoi and inhibited plant growth, pigmentation, and quality. DBP also induced oxidative damage, with increased reactive oxygen species levels and activation of antioxidant enzymes. Furthermore, DBP directly interacted with antioxidant enzymes at the molecular level. This study provides important information on the risk of DBP toxicity to vegetable crops.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Food Science & Technology
Nourhene Zammel, Mohd Saeed, Nouha Bouali, Salem Elkahoui, Jahoor M. Alam, Tarek Rebai, Mohd A. Kausar, Mohd Adnan, Arif J. Siddiqui, Riadh Badraoui
Summary: The study examined the antioxidant and anti-inflammatory effects of ginger and wild leek aqueous extracts in a carrageenan-induced acute inflammation model, along with measurements of inflammatory markers and oxidative stress variables. In silico molecular docking simulation revealed high affinities between the main components of ginger and wild leek with toll-like receptor 6 (TLR6). Histological examinations of paw edema showed that both extracts alleviated inflammation and oxidative stress, demonstrating anti-edematous, antioxidant, and anti-inflammatory activities. The results support the potential pharmacological use of these spices in managing inflammatory disorders and oxidative damage, with in silico assays effectively explaining the in vivo effects compared to indomethacin.
Article
Biochemistry & Molecular Biology
Iram Mushtaq, Irrum Mushtaq, Asia Akhlaq, Sumaira Usman, Ayesha Ishtiaq, Mehmand Khan, Ghazala Mustafa, Muhammad Saad Khan, Iqra Urooj, Shabana Bibi, Faroha Liaqat, Zareen Akhtar, Iram Murtaza
Summary: miR-15a-5p regulates MFN-2 and the compounds ES-37 and L-37 have a cardioprotective effect. They can attenuate oxidative stress and enhance anti-oxidative signaling mechanism to optimize cardiac hypertrophy response. The docking results show that ES-37 has greater binding affinity with the target proteins compared to L-37, with the highest binding values reported for MFN-2.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Environmental Sciences
Nan Jiang, Xianxu Li, Qian Wang, Baikerouzi Baihetiyaer, Xiaoteng Fan, Mingsheng Li, Huimin Sun, Xianqiang Yin, Jun Wang
Summary: This study comprehensively investigated the ecotoxicological effects and potential mechanisms of propofol on zebrafish embryos. The results showed that propofol has moderate toxicity on zebrafish embryos, affecting their hatchability and development. Propofol can trigger reactive oxygen species generation, lipid peroxidation, DNA damage, and disturb the nervous system.
Article
Environmental Sciences
Yuhao Chu, Chaofan Zhang, Shih-Hsin Ho
Summary: This study investigated the biological response of different alkyl-OPFRs on aquatic microalgae through computational simulation and cellular responses, revealing a significant correlation between the toxicity of alkyl-OPFRs and their molecular structures.