Journal
ONCOTARGETS AND THERAPY
Volume 13, Issue -, Pages 3881-3901Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/OTT.S244860
Keywords
delta-like ligands; notch signaling; cancer; therapy
Categories
Funding
- National Natural Science Foundation of China [81760328]
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Delta-like ligands (DLLs) control Notch signaling. DLL1, DLL3 and DLL4 are frequently deregulated in cancer and influence tumor growth, the tumor vasculature and tumor immunity, which play different roles in cancer progression. DLLs have attracted intense research interest as anti-cancer therapeutics. In this review, we discuss the role of DLLs in cancer and summarize the emerging DLL-relevant targeting methods to aid future studies.
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