Article
Anesthesiology
Rafael Galvez Mateos, Daniel Samper Bernal, Luis Miguel Torres Morera, Cesar Margarit Ferri, Ana Esquivias Escobar
Summary: The study evaluated the long-term effectiveness, tolerability, and safety of tapentadol PR in patients with severe chronic OA knee pain or LBP, showing sustained pain relief and quality of life for up to 72 treatment weeks with relatively stable dosing, and a good safety profile, suggesting the usefulness of tapentadol PR for these patients with limited risk for tolerance development.
Review
Pharmacology & Pharmacy
Lucien Roulet, Victoria Rollason, Jules Desmeules, Valerie Piguet
Summary: Tapentadol and tramadol share similarities in pharmacological mechanisms, efficacy, and safety profiles, with tapentadol being slightly more potent. Both drugs have similar toxic side effect profiles, but tapentadol may lead to fewer serotonergic adverse effects and more opioid-related adverse effects compared to tramadol. While tramadol has more real-world safety data available, the safety of tapentadol in real-world conditions remains uncertain.
Article
Rheumatology
Jesus Pujol, Gerard Martinez-Vilavella, Andrea Doreste, Laura Blanco-Hinojo, Fabiola Ojeda, Jone Llorente-Onaindia, Luciano Polino, Joan Deus, Jordi Monfort
Summary: The empirical test using functional MRI found that tapentadol treatment for pain-sensitized knee OA patients resulted in paradoxical effects of spread of cortical response and stronger activation in prefrontal areas. These findings were consistent with the higher clinical ratings of pain sensitization under tapentadol and the significant positive association between the number of tapentadol tablets and the evoked subjective pain.
Article
Multidisciplinary Sciences
Jordi Barrachina, Cesar Margarit, Javier Muriel, Santiago Lopez-Gil, Vicente Lopez-Gil, Amaya Vara-Gonzalez, Beatriz Planelles, Maria-del-Mar Inda, Domingo Morales, Ana M. Peiro
Summary: This study compared the effectiveness and safety of Tapentadol and oxycodone/naloxone in chronic non-cancer pain patients and found that Tapentadol provided better pain relief and tolerability. Further research is needed to understand the potential influence of COMT gene and sex on the side effects of oxycodone/naloxone.
SCIENTIFIC REPORTS
(2022)
Article
Clinical Neurology
Leonardo Kapural, Amela Minerali, Matthew Sanders, Matejic Matea, Simran Dua
Summary: This study found that cooled radiofrequency ablation (CRFA) was more effective than traditional radiofrequency ablation (tRFA) in treating chronic knee pain, with longer duration and greater intensity of pain relief.
JOURNAL OF PAIN RESEARCH
(2022)
Article
Rheumatology
Hans Guehring, Flavie Moreau, Benjamin Daelken, Christoph Ladel, Oliver Guenther, Asger Reinstrup Bihlet, Wolfgang Wirth, Felix Eckstein, Marc Hochberg, Philip G. Conaghan
Summary: The study assessed pain outcomes and cartilage thickness change in knee osteoarthritis patients at risk of further progression treated with sprifermin. The subgroup at risk showed faster disease progression and maintained net benefit on total cartilage thickness during treatment.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Geriatrics & Gerontology
Ulderico Freo, Maurizio Furnari, Francesco Ambrosio, Paolo Navalesi
Summary: The study indicates that tapentadol extended release maintains efficacy and good tolerability in elderly patients with chronic low back pain, providing significant pain relief, and improving quality of life and sleep.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Natasja M. van Schoor, Erik J. Timmermans, Martijn Huisman, Alicia Gutierrez-Misis, Willem Lems, Elaine M. Dennison, Maria Victoria Castell, Michael D. Denkinger, Nancy L. Pedersen, Stefania Maggi, Dorly J. H. Deeg
Summary: This study aims to explore resilience and its predictors in older adults with lower limb osteoarthritis (LLOA) and persistent severe pain. The results show that only a few patients with LLOA and persistent severe pain exhibit good physical functioning, while about half show good mental or social functioning. The predictors of resilience differ across the different domains of functioning.
Article
Orthopedics
Jenifer M. Pugliese, Peter C. Coyle, Patrick J. Knox, J. Megan Sions, Charity G. Patterson, Ryan T. Pohlig, Corey B. Simon, Debra K. Weiner, Steven Z. George, Sara Piva, Gregory E. Hicks
Summary: This study aims to compare the effects of hip-focused and spine-focused LBP treatments on disability and physical performance in a subgroup of older adults with CLBP and hip pain.
Article
Neurosciences
Jakub Mlost, Przemyslaw Kac, Marta Kedziora, Katarzyna Starowicz
Summary: This study demonstrates the anti-nociceptive and chondroprotective potential of beta-Caryophyllene (BCP) in an animal model of osteoarthritis (OA). BCP acts as a natural agonist of CB2 and does not produce tolerance for analgesic effects. These findings suggest that BCP could be a novel therapeutic strategy for treating OA.
Article
Medicine, General & Internal
Byung Woo Cho, Du Seong Kim, Hyuck Min Kwon, Ick Hwan Yang, Woo-Suk Lee, Kwan Kyu Park
Summary: This study aimed to investigate the association between knee pain and metabolic diseases, specifically hypercholesterolemia, in elderly individuals with osteoarthritis. The results revealed a positive correlation between hypercholesterolemia and knee pain in the OA group, independent of other metabolic diseases, highlighting the need for further exploration of longitudinal associations in arthritic pain.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
Ayman Eissa, Eva Tarau, Christoph Beuter, Tatjana Radic, Estelle Watson, Melanie Sohns, Claudia Lefeber, Gregory B. Hammer
Summary: Tapentadol demonstrated favorable pharmacokinetics and safety in children <2 years of age. Both single and multiple doses showed efficacy in pain management, with generally good tolerability.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Physiology
Julia Devanne, Andre Dufour, Olivier Despres, Thierry Pebayle, Segolene Lithfous
Summary: This study aimed to explore the connection between local vasodilation and pain perception in elderly individuals, with the hypothesis that altered local cutaneous blood flow contributes to the decrease in pain tolerance with age. The results showed that pain tolerance is impaired in the elderly, and there is a correlation between local blood flow and pain judgment in this group.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Acoustics
Scott W. Young, Nirvikar Dahiya, Johnny Yi, Megan Wasson, John Davitt, Maitray D. Patel
Summary: The study demonstrates that the uterine sliding sign significantly improves the diagnostic performance in predicting deeply infiltrating endometriosis. By including uterine sliding sign videos in the standard sonographic protocol, the sensitivity and specificity for detecting endometriosis in patients with chronic pelvic pain or history of endometriosis can be enhanced.
JOURNAL OF ULTRASOUND IN MEDICINE
(2021)
Article
Clinical Neurology
Kenji Miki, Makoto Ohta, Manabu Abe, Hiroki Yoshimatsu, Koichi Fujii, Nozomi Ebata, Christine R. West, Mark T. Brown, Glenn Pixton, Naoki Isogawa
Summary: This study analyzed the efficacy and safety of tanezumab in Japanese patients with moderate-to-severe osteoarthritis. The results showed that tanezumab had greater improvements in pain, physical function, and patient assessment compared to nonsteroidal anti-inflammatory drugs (NSAID), but higher doses of tanezumab increased the risk of joint safety issues.