Article
Virology
Kai Ren, Honggang Sun, Limin Chen, Ningning Chen, Lu Yu
Summary: MxA inhibits ZIKV replication by activating the type I interferon signaling pathway, without affecting virus entry. Upregulation of MxA is accompanied by increased expression levels of RIG-I, MDA5, TLR3, IRF3, IFN alpha, and IFNI3. The inhibitory effect of MxA on ZIKV replication is abolished in cells lacking the type I interferon receptor (IFNAR).
Article
Immunology
Yanpeng Li, Haodong Cui, Shipeng Li, Xingyan Li, Hongtao Guo, Kutty Selva Nandakumar, Zhilei Li
Summary: Research has shown that Kaempferol can improve psoriasis and alleviate its skin lesions. It exerts its therapeutic effects by modulating the IFN-gamma-induced JAK-STAT signaling pathway and reducing the number of inflammatory cells. These findings provide a basis for clinical application.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Fisheries
Yapeng Liu, Hailing Du, Shanghong Wang, Yangfeng Lv, Hang Deng, Kaile Chang, Pengcheng Zhou, Chengyu Hu
Summary: The study reveals that TNK1 plays a crucial role in the JAK-STAT pathway in fish, enhancing the expression of IFN I.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Environmental Sciences
Mengke Tang, Yifan Zhao, Yue Zhai, Yufan Zhang, Yalin Liu, Ting Liu, Jiaojiao Wu, Leyi He, Ye Yao, Peng Xue, Miao He, Yanyi Xu, Shaoqing Feng, Weidong Qu, Yubin Zhang
Summary: This study reveals the impact of Hg on the development of monocytes. Treatment with HgCl2 promotes the differentiation of monocytes and increases their quantity through activating certain signaling pathways. The increased monopoiesis by Hg is associated with an increased inflammatory status.
ENVIRONMENTAL POLLUTION
(2023)
Article
Oncology
A. H. Gao, Y. R. Hu, W. P. Zhu
Summary: IFN-gamma inhibits ovarian cancer progression by enhancing SOCS1 to suppress STAT3 and STAT5 protein phosphorylation, thus preventing cell proliferation, migration, invasion, and promoting apoptosis.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: This review highlights the importance of the JAK/STAT pathway in hepatocellular carcinoma (HCC) and its association with factors such as chronic inflammation and cirrhosis. It also summarizes recent advancements in targeting the JAK/STAT pathway for HCC treatment, emphasizing the potential of this pathway as a promising avenue for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Songtao Gu, Jingjing Liang, Jianwei Zhang, Zhichao Liu, Yang Miao, Yuli Wei, Shimeng Li, Jinying Gu, Yunyao Cui, Ting Xiao, Xiaohe Li, Cheng Yang
Summary: Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with unknown cause and limited treatment options. Transforming growth factor-beta 1 (TGF-beta 1) is recognized as a central pathway in pulmonary fibrosis. This study explored the potential effect and mechanism of JAK1/2 inhibitor baricitinib on reducing TGF-beta 1-induced fibroblast activation and epithelial injury, as well as attenuating bleomycin-induced pulmonary fibrosis in mice.
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Plant Sciences
Xinying Fu, Zhengji Sun, Qingyin Long, Wei Tan, Huang Ding, Xiaodan Liu, Lu Wu, Yang Wang, Wei Zhang
Summary: This study demonstrated that glycosides, the main active components of BYHWD, can inhibit atherosclerosis progression by alleviating atherosclerotic inflammation, with the inhibitory mechanism targeting the activation of the JAK/STAT signaling pathway.
Review
Neurosciences
Huaiyu Sun, Di Ma, Yu Cheng, Jiaai Li, Wuqiong Zhang, Ting Jiang, Zhaoran Li, Xuewei Li, Hongmei Meng
Summary: Epilepsy is characterized by spontaneous recurrent seizures in the brain. Inflammatory mediators and immune cells play a role in epileptic seizures, and the JAK-STAT signaling pathway shows potential as a target for epilepsy treatment.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Dhiraj Gurjar, Sananda Kumar Patra, Neelam Bodhale, Nibedita Lenka, Bhaskar Saha
Summary: IFN-gamma plays a critical role in both innate and adaptive immunity, and its responsiveness in infected macrophages determines the efficacy of anti-Leishmania function. Impaired IFN-gamma responsiveness is caused by altered expression and heterodimerization of IFN-gamma receptors, as well as reduced signaling molecule phosphorylation and increased degradation. The parasite load is not only influenced by the production of IFN-gamma but also by its responsiveness.
Article
Oncology
Xinbo Yu, Dandan Zhu, Bixian Luo, Wei Kou, Yuling Cheng, Yu Zhu
Summary: IFN gamma enhances erastin-induced ferroptosis in adrenocortical carcinoma (ACC) cells by suppressing the expression of a negative regulator of ferroptosis and activating the JAK/STAT pathway, leading to increased iron accumulation, lipid peroxidation, and mitochondrial damage.
Article
Cell Biology
Bin Lv, Guangyu Gao, Yuhong Guo, Zhiping Zhang, Renfeng Liu, Zhengzai Dai, Cheng Ju, Yiping Liang, Xiaofeng Tang, Min Tang, Xiao-Bin Lv
Summary: This study utilized the Gene Expression Omnibus (GEO) database to analyze differential regulation in osteosarcoma cells compared to osteoblasts, identifying 341 mRNAs, with Serglycin being highlighted as a key gene influencing invasion and proliferation of osteosarcoma cells.
Article
Cell Biology
Xiaoqiong Duan, Xiao Liu, Wenting Li, Jacinta A. Holmes, Annie J. Kruger, Chunhui Yang, Yujia Li, Min Xu, Haiyan Ye, Shuang Li, Xinzhong Liao, Qiuju Sheng, Dong Chen, Tuo Shao, Zhimeng Cheng, Batul Kaj, Esperance A. Schaefer, Shilin Li, Limin Chen, Wenyu Lin, Raymond T. Chung
Article
Multidisciplinary Sciences
Mohamed S. Draz, Anish Vasan, Aradana Muthupandian, Manoj Kumar Kanakasabapathy, Prudhvi Thirumalaraju, Aparna Sreeram, Sanchana Krishnakumar, Vinish Yogesh, Wenyu Lin, Xu G. Yu, Raymond T. Chung, Hadi Shafiee