Article
Pharmacology & Pharmacy
Zili Hu, Zhenyun Yang, Jiongliang Wang, Yizhen Fu, Zhiwen Hu, Zhongguo Zhou, Minshan Chen, Yaojun Zhang
Summary: This study suggests that neoadjuvant hepatic arterial infusion chemotherapy followed by hepatectomy is associated with longer survival outcome compared to hepatectomy alone for hepatocellular carcinoma patients with portal vein tumor thrombus. The survival benefit is limited to patients who respond to neoadjuvant FOLFOX-HAIC.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Yangxun Pan, Jie Mei, Jinbin Chen, Deyao Zhang, Juncheng Wang, Xiaohui Wang, Minjiang Yi, Zhongguo Zhou, Yaojun Zhang, Minshan Chen, Rongping Guo, Li Xu
Summary: This study aimed to investigate the survival associations of adjuvant portal vein perfusion chemotherapy (PVC) and neoadjuvant hepatic arterial infusion chemotherapy (HAIC) in patients with resectable BCLC stage B/C HCC. The results showed that compared with adjuvant PVC, patients treated with neoadjuvant HAIC had better survival outcomes and lower recurrence rates.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Review
Oncology
Hao Sun, Bing Ma, Ning Sun, Han Bai, Xuejian Li, Chengshuo Zhang
Summary: This study compared the oncological prognosis of different perioperative locoregional adjuvant treatments for HCC with PVTT. The results showed that adjuvant therapy with radiotherapy had the lowest hazard ratio for both overall survival (OS) and recurrence-free survival (RFS). It was concluded that perioperative locoregional adjuvant therapy, especially radiotherapy, provides survival benefits and reduces the risk of recurrence for HCC patients with PVTT.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Oncology
Chengjian He, Naijian Ge, Xiangdong Wang, Hai Li, Shiguang Chen, Yefa Yang
Summary: This study evaluated the safety and efficacy of conversion therapy with portal vein embolization (PVE) and transcatheter arterial chemoembolization (TACE) in patients with large unresectable hepatocellular carcinoma (HCC) and ipsilateral portal vein tumor thrombus (PVTT). The results showed that PVE + TACE treatment prolonged overall survival and conferred more favorable outcomes compared to treatment with tyrosine kinase inhibitors (TKIs) + TACE.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Shao-Hua Li, Jie Mei, Yuan Cheng, Qiang Li, Qiao-Xuan Wang, Chong-Kai Fang, Qiu-Cheng Lei, Hua-Kun Huang, Ming-Rong Cao, Rui Luo, Jing-Duo Deng, Yu-Chuan Jiang, Rong-Ce Zhao, Liang-He Lu, Jing-Wen Zou, Min Deng, Wen-Ping Lin, Ren-Guo Guan, Yu-Hua Wen, Ji-Bin Li, Lie Zheng, Zhi-Xing Guo, Yi-Hong Ling, Huan-Wei Chen, Chong Zhong, Wei Wei, Rong-Ping Guo
Summary: This study investigated the efficacy and safety of postoperative adjuvant hepatic arterial infusion chemotherapy (HAIC) with 5-fluorouracil and oxaliplatin (FOLFOX) in hepatocellular carcinoma (HCC) patients with microvascular invasion (MVI). The results showed that HAIC significantly improved disease-free survival (DFS) and had acceptable toxicities compared to routine follow-up.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Pharmacology & Pharmacy
Zili Hu, Zhenyun Yang, Yangxun Pan, Yizhen Fu, Jiongliang Wang, Zhongguo Zhou, Minshan Chen, Dandan Hu, Yaojun Zhang
Summary: This study analyzed the data of 1251 HCC patients and found that preoperative FOLFOX-HAIC is associated with longer survival. A predictive nomogram was also established to predict the outcome of this treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Surgery
J. Heil, R. Korenblik, F. Heid, W. O. Bechstein, M. Bemelmans, C. Binkert, B. Bjornsson, S. Breitenstein, O. Detry, A. Dili, R. F. Dondelinger, L. Gerard, T. Gimenez-Maurel, B. Guiu, D. Heise, M. Hertl, J. A. Kalil, J. J. Klein, A. Lakoma, U. P. Neumann, B. Olij, S. G. Pappas, P. Sandstrom, A. Schnitzbauer, A. Serrablo, J. Tasse, C. Van der Leij, P. Metrakos, R. Van Dam, E. Schadde
Summary: The study found that simultaneous embolization of portal and hepatic veins (PVE/HVE) can accelerate future liver remnant (FLR) hypertrophy and improve resectability, with better outcomes compared to portal vein embolization (PVE) alone.
BRITISH JOURNAL OF SURGERY
(2021)
Article
Oncology
Yiwen Qiu, Yi Yang, Tao Wang, Shu Shen, Wentao Wang
Summary: This study investigated the impact of microscopic portal vein invasion (MPVI) on the efficacy of postoperative adjuvant transcatheter arterial chemoembolization (PA-TACE). The results showed that PA-TACE had better recurrence-free survival (RFS) and overall survival (OS) outcomes in patients without MPVI. However, for patients with MPVI, PA-TACE did not significantly improve RFS or OS outcomes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Surgery
Manh-Thau Cao, Ryota Higuchi, Takehisa Yazawa, Shuichiro Uemura, Wataru Izumo, Yutaro Matsunaga, Yasuto Sato, Satoru Morita, Toru Furukawa, Hiroto Egawa, Masakazu Yamamoto
Summary: The study found that narrowing of the remnant portal vein diameter and a decreased portal vein angle after major hepatectomy for perihilar cholangiocarcinoma are significant independent risk factors for postoperative portal vein thrombosis.
LANGENBECKS ARCHIVES OF SURGERY
(2021)
Review
Surgery
Remon Korenblik, Jasper F. J. A. van Zon, Bram Olij, Jan Heil, Maxime J. L. Dewulf, Ulf. P. Neumann, Steven W. M. Olde Damink, Christoph A. Binkert, Erik Schadde, Christiaan van der Leij, Ronald. M. van Dam, DRAGON Trials Collaborative
Summary: The simultaneous portal and hepatic vein embolization (PVE/HVE) appears to increase the resectability of bi-lobar liver tumors and results in faster and more pronounced hypertrophy compared with portal vein embolization (PVE) alone.
Letter
Oncology
Lei Liang, Chao Li, Ming-Da Wang, Hong Wang, Ya-Hao Zhou, Yong-Yi Zeng, Wan-Guang Zhang, Ting-Hao Chen, Nan-Ya Wang, Jie Li, Yao-Ming Zhang, Yu Wang, Wei-Min Gu, Hao Xing, Yong-Kang Diao, Wan Yee Lau, Cheng-Wu Zhang, Timothy M. Pawlik, Feng Shen, Dong-Sheng Huang, Tian Yang
Summary: This study constructed an online calculator for assessing the survival benefit of adjuvant TACE for patients with resected HCC based on large-scale real-world data. By incorporating existing independent survival predictors, two prediction models were successfully developed and showed good calibration and discrimination.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Tai-Wei Ye, Dong-Dong Wang, Wen-Feng Lu, Ya-Ming Xie, Fei-Qi Xu, Tian-Wei Fu, Kang-Jun Zhang, Si-Yu Liu, Gui-Lin Xie, Jian Cheng, Kai Jiang, Zun-Qiang Xiao, Wei-Feng Yao, Guo-Liang Shen, Jun-Wei Liu, Dong-Sheng Huang, Cheng-Wu Zhang, Lei Liang
Summary: This study aimed to evaluate the survival benefit of adjuvant transcatheter arterial chemoembolization (TACE) for patients with hepatocellular carcinoma (HCC) after anatomical hepatectomy (AH). The results showed that patients who received adjuvant TACE had better overall survival (OS) and recurrence-free survival (RFS). Therefore, adjuvant TACE should be considered for patients with a high risk of recurrence.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Peng-Peng Li, Gang Huang, Ning-Yang Jia, Ze-Ya Pan, Hui Liu, Yun Yang, Cheng-Jian He, Wan Yee Lau, Ye-Fa Yang, Wei-Ping Zhou
Summary: ALPPS was found to result in better intermediate-term overall survival outcomes compared to TACE+PVE in patients with hepatitis B-related hepatocellular carcinoma (HCC) who were initially unresectable, although at the expense of a higher perioperative morbidity rate.
HEPATOBILIARY SURGERY AND NUTRITION
(2022)
Article
Oncology
Meiyue Li, Shen Lin, Leslie Wilson, Pinfang Huang, Hang Wang, Shubin Lai, Liangliang Dong, Xiongwei Xu, Xiuhua Weng
Summary: The study evaluated the cost-effectiveness of HAIC plus sorafenib (SoraHAIC) versus standard care for HCC patients from the Chinese health system perspective. The results indicated that SoraHAIC was not cost-effective in medium- and low-income regions of China, but there was a 38.8% probability that it would be cost-effective in developed areas (such as Beijing).
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Xin Luo, Rui-zhi Chang, Dong Kuang, Mingming Yuan, Gan-xun Li, Bixiang Zhang, Yan-jun Wang, Wan-guang Zhang, Ze-yang Ding
Summary: This article reports a case of combined therapy for advanced HCC. The patient received HAIC, lenvatinib, and PD-1 antibody treatment and underwent salvage hepatectomy after transcatheter arterial chemoembolization. The case demonstrates the efficacy of this combined treatment approach for advanced HCC patients.
FRONTIERS IN IMMUNOLOGY
(2023)